MICROARRAY CENTERS FOR RESEARCH ON THE NERVOUS SYSTEM RELEASE DATE: April 23, 2004 RFA Number: RFA-NS-05-002 EXPIRATION DATE: August 10, 2004 Department of Health and Human Services (DHHS) PARTICIPATING ORGANIZATION: National Institutes of Health (NIH) (http://www.nih.gov) COMPONENTS OF PARTICIPATING ORGANIZATION: National Institute of Neurological Disorders and Stroke (NINDS) (http://www.ninds.nih.gov) National Institute of Mental Health (NIMH) (http://www.nimh.nih.gov) CATALOG OF FEDERAL DOMESTIC ASSISTANCE NUMBERS: 93.853, 93.242 LETTER OF INTENT RECEIPT DATE: July 12, 2004 APPLICATION RECEIPT DATE: August 9, 2004 THIS RFA CONTAINS THE FOLLOWING INFORMATION o Purpose of this RFA o Research Objectives o Mechanism of Support o Funds Available o Eligible Institutions o Individuals Eligible to Become Principal Investigators o Special Requirements o Where to Send Inquiries o Letter of Intent o Submitting an Application o Peer Review Process o Review Criteria o Receipt and Review Schedule o Award Criteria o Required Federal Citations PURPOSE OF THIS RFA The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH) invite applications for support of Microarray Centers. These Centers will support gene expression profiling in the nervous system through the application of microarray technologies. The Microarray Centers, which will function as a consortium, will provide reagents, services, and training to the neuroscience community, on a fee-for-service basis. The NINDS/NIMH Microarray Consortium was originally funded for three years in June 2002 under RFA-NS-02-001 as a consortium of three Microarray Centers. Information on the structure of the consortium and on the products and services offered to users is available on the consortium website (http://arrayconsortium.tgen.org). Further information on this initiative is available by viewing the transcript of a pre-application meeting that was held at NIH on June 7, 2001 http://www.ninds.nih.gov/funding/technology_development/rfa-ns-02-001/ meeting_summary.htm). No pre-application meeting will be held for this RFA, which is a reissue of the original RFA. This recompetition of the Microarray Center awards will renew the consortium for five years. RESEARCH OBJECTIVES Background: Oligonucleotide and cDNA microarrays are used to make quantitative or relative measurements of gene expression. The microarrays contain nucleotide sequences corresponding to known genes or expressed sequence tags. A single array can contain thousands of genes, which may represent a significant subset of the genes, or even the entire genome, of an organism. A comparison of cells or tissues from experimental and control preparations provides data on differences in expression levels between the two conditions. Changes in gene expression of ubiquitously expressed genes might reveal clues to underlying, widespread alterations of cellular physiology. Changes in expression patterns of genes that are regulated temporally or spatially within the organism might provide information on developmental or disease processes. Changes in one or a few genes might lead to the discovery of individual molecular targets for drug therapy. Drawbacks to the application of microarray technologies to research problems include the expense of performing the experiments, and, in some cases, significant technical barriers to success. It is the goal of this RFA to establish up to three Microarray Centers that will work together in a consortium arrangement to provide microarray reagents, services, advice, and training to the neuroscience community at a reasonable cost. Objective and Scope: NINDS and NIMH will use the U24 Resource-Related Research Projects Cooperative Agreements funding mechanism to establish up to three Microarray Centers. The Centers will serve as regional and national resources to the neuroscience community. Each Center will be directed by a Principal Investigator (PI), and will receive guidance from NINDS and NIMH program staff to assist with identification and implementation of appropriate strategies and priorities. Although the Centers may specialize with regard to equipment, expertise, and proprietary reagents, they will work closely together in a consortium arrangement. The efforts of the Centers will be coordinated, strategically and functionally, with the result that the Centers will function as a single, national resource. Coordination of the Centers will be accomplished through close collaboration between the Center PIs, leadership and direction from NINDS and NIMH program staff, and oversight by a Steering Committee. A Consortium Advisory Panel (CAP), composed of experts not affiliated with the Centers, will be formed. The CAP will advise Center PIs and NINDS and NIMH program staff on the organization and operation of the microarray consortium. The CAP will address long-term strategic issues and policies, and will also assist with the development of general guidelines for daily operations, including the acceptance/rejection of projects and prioritization of workload. The Microarray Centers will provide services to NINDS-funded and NIMH- funded investigators to support microarray analyses on the nervous system. These services will include a broad spectrum of activities. In addition to providing commercial arrays, the Centers will produce arrays for use by the neuroscience community. These arrays may be standard arrays designed by the Centers for general use, or they may be custom arrays suited to the needs of smaller groups of investigators. The Centers will run array experiments, including hybridization reactions, array reading, and data analyses. The Centers will also advise and train the neuroscience community. They will assist with experimental design, and advise on how best to obtain experimental results. The Centers will train neuroscientists on the effective use of microarray experimental techniques, in an effort to disseminate expertise throughout the neuroscience community. The services provided by the Centers will be on a fee-for-service basis. Fees charged will recover product costs and service delivery costs. Research and development costs for array production and development of best practices will not be recovered, except in specific cases where custom arrays are developed for limited uses. A portion of the funding may be requested for equipment. Applications in response to this RFA should include detailed plans for the advisory, training, research and development, and fee-for-service functions of the Centers. Research projects associated with the Centers, including those of the PIs, are expected to have independent funding. SPECIAL REQUIREMENTS Program Income: Fees charged by the Centers will constitute Program Income. Program Income is gross income earned by the awardee that is directly generated by a supported activity or earned as a result of the award (see 45 CFR 74.2 and 74.24 for additional information). An estimate of the amount and source of Program Income that will be generated as a result of the award must be included on the Checklist Page of all competing and non- competing continuation applications. Net program income earned during a budget period must be reported on the annual Financial Status Report (FSR) (except for Program Income earned as a result of inventions, to which special rules apply). Costs incident to the generation of Program Income may be deducted from gross income to determine Program Income to be reported on the FSR, provided that these costs have not been charged to the award. Program Income earned during the project period shall be retained by the award recipient and used in the following way: The first $25,000 earned during a budget period is added to funds committed to the project or program, and used to further eligible project or program objectives; Any amount over $25,000 earned during a budget period is to be deducted from the total project or program allowable costs in determining the net allowable costs on which the federal share of costs is based. The NINDS and NIMH may offset a future award by this amount or reauthorize it for expenditure on a future award. Biannual Meetings: Center PIs and scientists, along with NINDS and NIMH program staff, will make up a Steering Committee that will meet twice annually at the NIH. Applications in response to this RFA should include a request for funds to cover the expense of attending the biannual Steering Committee meetings in Bethesda, Maryland. Data Sharing: Genomic data from microarray analyses are useful for many purposes. It is very important that the data generated from experiments supported by the Centers are shared with the broader scientific community. The consortium of Centers will require data sharing by users of the Centers products and services. The NINDS/NIMH Microarray Consortium (http://arrayconsortium.tgen.org) has developed and implemented a web portal for submission and review of projects and a data repository for the archiving and sharing of microarray data. Applications in response to this RFA should include plans for the local handling of microarray data and for communication with the consortium web portal and data repository. Terms and Conditions of Award: These special Terms of award are in addition to and not in lieu of otherwise applicable OMB administrative guidelines, HHS Grant Administration Regulations at 45 CFR Parts 74 and 92, and other HHS, PHS, and NIH Grant Administration policy statements. The administrative and funding instrument used for this program is a cooperative agreement (U24). As described previously, the dominant role and prime responsibility for the activity resides with the awardee(s) for the project as a whole, although specific tasks and activities in carrying out the project will be shared among the awardees, NINDS and NIMH program staff, and the CAP. 1. Awardee Rights and Responsibilities Awardees, as Center PIs, have primary responsibilities to define objectives and approaches, and to plan and conduct the activities of the Centers that they manage. Awardees will collaborate with other Center PIs, and coordinate Center developmental and fee-for-service activities with those of the other Centers. Each Center PI must agree to participate with NINDS and NIMH program staff and the CAP in coordinating the activities of the Centers, with the result that the Centers will function as a single consortium. Although each Center will be independently funded and managed, the planning and implementation of Center activities will be done in a way to maximize the overall effectiveness of the consortium of Centers. Each Center will maintain a log of Center usage by NINDS and NIMH grantees that records the products and services provided to the grantees, the fees charged for the products and services, and the institute (NINDS or NIMH) from which the grantee receives support. Prior to each non-competing renewal of these awards, each Center will submit to the NIH a progress report that describes the activities and accomplishments of the Center for the preceding award period, and the goals to be accomplished during the renewal period. The progress report will include the log of Center usage. The contents of the progress report will be used by NINDS and NIMH program staff, along with other information, to determine the amount of funding the Center will receive for the renewal period. Center PIs will attend, and participate in, biannual Steering Committee meetings at the NIH. Awardees will be voting members of the Steering Committee, and will accept any modification, deletion, or addition of Center activities that is approved by the Steering Committee. 2. NINDS and NIMH Program Staff Responsibilities NINDS and NIMH program staff, as Project Scientists, will have substantial scientific-programmatic involvement during conduct of this activity, through technical assistance, advice, and coordination above and beyond normal program stewardship for grants. The NIH Project Scientists will have a single, combined vote on the Steering Committee, and will participate with the other members of the committee in planning the overall structure and strategy of the consortium of Centers. Microarray technologies are evolving rapidly, and program staff will play an active role in assuring that Centers remain on the cutting edge of the research technologies. This role will be carried out by assisting the Center PIs and the CAP with assessing the current state of the technologies and methodologies for gene expression profiling. The Project Scientists will select and recruit the members of the CAP, who will each serve a five-year term. The Project Scientists will also have the responsibility of replacing CAP members that choose to leave the CAP. Project Scientists may, but are not required to, consult with Center PIs, CAP members, or other outside advisors when recruiting members of the CAP. NINDS and NIMH program staff will determine the amount of support that will be awarded to each Center as a non-competing renewal. The progress report received from each Center, along with other information, will be used to make this determination. The criteria used for this decision will include, but not be limited to, Center production, customer satisfaction, and successful performance of the Center as a member of the consortium. NINDS and NIMH program staff will assist with and facilitate the coordination and research efforts of the Centers, but will not direct these activities. 3. Collaborative Responsibilities Consortium Advisory Panel The CAP will be composed of between four and six experts not associated with the Centers. This panel will provide oversight to the consortium, and advice to the Steering Committee and NIH. CAP members will provide technical and operational advice concerning both long-term developments and day-to-day operations at the Centers. The CAP members will choose a chairperson, who will coordinate communication among the members, and between the CAP, the Centers, and the Project Scientists. The CAP members will not vote on the Steering Committee, but may be invited to attend Steering Committee meetings, if attendance would significantly facilitate Steering Committee business. Periodically, at intervals determined by the Steering Committee, a formal request for advice on specific subjects will be submitted to the CAP. The CAP will convene to consider and formulate opinions on the questions submitted to it. NINDS and NIMH program staff will consider the opinions of the CAP with regard to overall consortium functioning, and the performance of individual Centers, when making determinations for renewal funding. Steering Committee A Steering Committee composed of the Center PIs, one additional manager or scientist from each Center, two NINDS Project Scientists, and one NIMH Project Scientist, will convene at the NIH twice annually. Each year the Steering Committee will select a chairperson who will serve a one-year term. The chairperson of the Steering Committee may not be a NINDS or NIMH Project Scientist. Each Center will have one Steering Committee vote, and the NIH will have one Steering Committee vote. In cases where members do not agree, any member may ask the chairperson to solicit a vote. In order for a decision or course of action to be finalized by the Steering Committee, a majority of the possible votes must be cast in favor of the decision or course of action. The Steering Committee will be the main governing board of the consortium of Microarray Centers. The committee may take actions, deemed appropriate by vote of the members when necessary, to facilitate the functioning of the consortium. Such actions might include, but are not limited to, formation of sub-committees, consultations with outside persons, and specialization of the Centers. Awardees will be required to accept and implement the common protocol and procedures approved by the Steering Committee. 4. Arbitration Any disagreement that may arise on scientific/programmatic matters (within the scope of the award) between award recipients and the NINDS or the NIMH may be brought to arbitration. An arbitration panel will be composed of three members one chosen by the Steering Committee (with NIH not voting) or by the individual awardee in the event of an individual disagreement, a second member selected by the NINDS and NIMH, and the third member selected by the two prior selected members. This special arbitration procedure in no way affects the awardee’s right to appeal an adverse action that is otherwise appealable in accordance with the PHS regulations at 42 CFR Part 50, Subpart D and HHS regulation at 45 CFR Part 16. MECHANISM OF SUPPORT The administrative and funding instrument to be used for this program will be the NIH Resource-Related Research Projects Cooperative Agreements award mechanism (U24), an assistance mechanism in which substantial NIH scientific and/or programmatic involvement with the awardee is anticipated during performance of the activity. Under the cooperative agreement, the NIH purpose is to support and/or stimulate the recipient’s activity by involvement in and otherwise working jointly with the award recipient in a partner role, but it is not to assume direction, prime responsibility, or a dominant role in the activity, as described under the section "Cooperative Agreement Terms and Conditions of Award." The total project period for an application submitted in response to this RFA may not exceed five years. At this time, NINDS and NIMH have not determined whether or how this solicitation will be continued beyond the present RFA. The anticipated award date is June 1, 2005. This RFA uses just-in-time concepts. It does not use the modular budgeting format. (http://grants.nih.gov/grants/funding/modular/modular.htm). FUNDS AVAILABLE NINDS and NIMH intend to commit up to $3.8 million in total costs to fund up to three successful applications in FY 2005 in response to this RFA. Applicants may request up to five years of support. Although the financial plans of NINDS and NIMH provide support for this program, awards pursuant to this RFA are contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications. ELIGIBLE INSTITUTIONS You may submit an application if your institution has any of the following characteristics: o For-profit or non-profit organizations o Public or private institutions, such as universities, colleges, hospitals, and laboratories o Units of State and local governments o Eligible agencies of the federal government o Foreign institutions are not eligible to apply. INDIVIDUALS ELIGIBLE TO BECOME PRINCIPAL INVESTIGATORS Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. WHERE TO SEND INQUIRIES We encourage inquiries concerning this RFA and welcome the opportunity to answer questions from potential applicants. Inquiries may fall into three areas: scientific/research, peer review, and financial or grants management issues: Direct inquiries regarding scientific and other application-related issues, and inquiries specific to NINDS to: Thomas Miller, Ph.D. Technology Development National Institute of Neurological Disorders and Stroke 6001 Executive Blvd., Room 2139 Bethesda, MD 20892 Tel: 301-496-1779 Fax: 301-402-1501 Email: tm208y@nih.gov Direct inquiries specific to NIMH to: Steven O. Moldin, Ph.D. Division of Neuroscience & Basic Behavioral Science National Institute of Mental Health 6001 Executive Blvd., Room 7191, MSC 9643 Bethesda, MD 20892-9643 Tel: 301-443-2037 Fax: 301-443-9890 Email: smoldin@mail.nih.gov Direct inquiries regarding review issues to: Alan L. Willard, Ph.D. Chief, Scientific Review Branch National Institute of Neurological Disorders and Stroke 6001 Executive Blvd., Room 3201 Bethesda, MD 20892 Tel: 301-496-9223 Fax: 301-402-0182 Email: aw135y@nih.gov Direct inquiries regarding fiscal matters to: Denise E. Chatman Grants Management Branch National Institute of Neurological Disorders and Stroke 6001 Executive Blvd., Room 3269 Bethesda, MD 20892 Tel: 301-496-3993 Fax: 301-402-0219 Email: dc55g@nih.gov LETTER OF INTENT Prospective applicants are asked to submit a letter of intent that includes the following information: o Descriptive title of the proposed research o Name, address, and telephone number of the Principal Investigator o Names of other key personnel o Participating institutions o Number and title of this RFA Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review. The letter of intent is to be sent by the date listed at the beginning of this document. The letter of intent should be sent to: Thomas Miller, Ph.D. Technology Development National Institute of Neurological Disorders and Stroke 6001 Executive Blvd., Room 2139 Bethesda, MD 20892 Tel: 301-496-1779 Fax: 301-402-1501 Email: tm208y@nih.gov SUBMITTING AN APPLICATION Applications must be prepared using the PHS 398 research grant application instructions and forms (rev. 5/2001). Applications must have a DUN and Bradstreet (D&B) Data Universal Numbering System (DUNS) number as the Universal Identifier when applying for Federal grants or cooperative agreements. The DUNS number can be obtained by calling (866) 705-5711 or through the web site at http://www.dunandbradstreet.com/. The DUNS number should be entered on line 11 of the face page of the PHS 398 form. The PHS 398 document is available at http://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive format. For further assistance contact GrantsInfo, Telephone (301) 710-0267, Email: GrantsInfo@nih.gov. USING THE RFA LABEL: The RFA label available in the PHS 398 (rev. 5/2001) application form must be affixed to the bottom of the face page of the application. Type the RFA number on the label. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition, the RFA title and number must be typed on line 2 of the face page of the application form and the YES box must be marked. The RFA label is also available at: http://grants.nih.gov/grants/funding/phs398/labels.pdf. SENDING AN APPLICATION TO THE NIH: Submit a signed, typewritten original of the application, including the Checklist, and three signed, photocopies, in one package to: Center for Scientific Review National Institutes of Health 6701 Rockledge Drive, Room 1040, MSC 7710 Bethesda, MD 20892-7710 Bethesda, MD 20817 (for express/courier service) At the time of submission, two additional copies of the application and all copies of the appendix material must be sent to: Alan L. Willard, Ph.D. Chief, Scientific Review Branch National Institute of Neurological Disorders and Stroke 6001 Executive Blvd., Room 3201 Bethesda, MD 20892 Rockville, MD 20852 (for express/courier service) Tel: 301-496-9223 Fax: 301-402-0182 Email: aw135y@nih.gov APPLICATION PROCESSING: Applications must be received on or before the application receipt date listed in the heading of this RFA. If an application is received after that date, it will be returned to the applicant without review. Although there is no immediate acknowledgement of the receipt of an application, applicants are generally notified of the review and funding assignment within 8 weeks. The Center for Scientific Review (CSR) will not accept any application in response to this RFA that is essentially the same as one currently pending initial review, unless the applicant withdraws the pending application. However, when a previously unfunded application, originally submitted as an investigator-initiated application, is to be submitted in response to an RFA, it is to be prepared as a NEW application. That is, the application for the RFA must not include an introduction describing the changes and improvements made, and the text must not be marked to indicate the changes from the previous unfunded version of the application. PEER REVIEW PROCESS Upon receipt, applications will be reviewed for completeness by the CSR and responsiveness by NINDS. Incomplete applications will not be reviewed. If the application is not responsive to the RFA, it will not be reviewed. Applications that are complete and responsive to the RFA will be evaluated for scientific and technical merit by an appropriate peer review group convened by NINDS in accordance with the review criteria stated below. As part of the initial merit review, all applications will: o Undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of the applications under review, will be discussed and assigned a priority score o Receive a written critique o Receive a second level review by the National Advisory Neurological Disorders And Stroke Council and the National Advisory Mental Health Council. REVIEW CRITERIA The goals of NIH-supported research are to advance our understanding of biological systems, improve the control of disease, and enhance health. In the written comments, reviewers will be asked to evaluate the application in order to judge the likelihood that the proposed research will have a substantial impact on the pursuit of these goals. The scientific review group will address and consider each of the following criteria in assigning the application’s overall score, weighting them as appropriate for each application. o Significance o Approach o Innovation o Investigator o Environment The application does not need to be strong in all categories to be judged likely to have major scientific impact and thus deserve a high priority score. For example, an investigator may propose to carry out important work that by its nature is not innovative but is essential to move a field forward. SIGNIFICANCE: Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge be advanced? What will be the effect of these studies on the concepts or methods that drive this field? APPROACH: Are the conceptual framework, design, methods, and analyses adequately developed, well-integrated, and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternative tactics? INNOVATION: Does the project employ novel concepts, approaches or methods? Are the aims original and innovative? Does the project challenge existing paradigms or develop new methodologies or technologies? INVESTIGATOR: Is the investigator appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the principal investigator and other researchers (if any)? ENVIRONMENT: Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed experiments take advantage of unique features of the scientific environment or employ useful collaborative arrangements? Is there evidence of institutional support? ADDITIONAL REVIEW CRITERIA: In addition to the above criteria, the following items will be considered in the determination of scientific merit and the priority score: o The adequacy of the proposed plan to provide advice and training to the neuroscience community. o The adequacy of the proposed fee-for-service plan, including administration and funds management CARE AND USE OF VERTEBRATE ANIMALS IN RESEARCH: If vertebrate animals are to be used in the project, the five items described under Section f of the PHS 398 research grant application instructions (rev. 5/2001) will be assessed. ADDITIONAL REVIEW CONSIDERATIONS Sharing Research Data Applicants requesting more than $500,000 in direct costs in any year of the proposed research must include a data sharing plan in their application. The reasonableness of the data sharing plan or the rationale for not sharing research data will be assessed by the reviewers. However, reviewers will not factor the proposed data sharing plan into the determination of scientific merit or priority score. http://grants.nih.gov/grants/policy/data_sharing/ BUDGET: The reasonableness of the proposed budget and the requested period of support in relation to the proposed research. RECEIPT AND REVIEW SCHEDULE Letter of Intent Receipt Date: July 12, 2004 Application Receipt Date: August 9, 2004 Peer Review Date: November 2004 Council Review: February 2005 Earliest Anticipated Start Date: June 1, 2005 AWARD CRITERIA Award criteria that will be used to make award decisions include: o Scientific merit (as determined by peer review) o Availability of funds o Programmatic priorities, and program balance o Geographic balance REQUIRED FEDERAL CITATIONS SHARING RESEARCH DATA: Investigators submitting an NIH application seeking $500,000 or more in direct costs in any single year are expected to include a plan for data sharing or state why this is not possible. http://grants.nih.gov/grants/policy/data_sharing Investigators should seek guidance from their institutions, on issues related to institutional policies, local IRB rules, as well as local, state and federal laws and regulations, including the Privacy Rule. Reviewers will consider the data sharing plan but will not factor the plan into the determination of the scientific merit or the priority score. PUBLIC ACCESS TO RESEARCH DATA THROUGH THE FREEDOM OF INFORMATION ACT: The Office of Management and Budget (OMB) Circular A-110 has been revised to provide public access to research data through the Freedom of Information Act (FOIA) under some circumstances. Data that are (1) first produced in a project that is supported in whole or in part with Federal funds and (2) cited publicly and officially by a Federal agency in support of an action that has the force and effect of law (i.e., a regulation) may be accessed through FOIA. It is important for applicants to understand the basic scope of this amendment. NIH has provided guidance at http://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm. URLs IN NIH GRANT APPLICATIONS OR APPENDICES: All applications and proposals for NIH funding must be self-contained within specified page limitations. Unless otherwise specified in an NIH solicitation, Internet addresses (URLs) should not be used to provide information necessary to the review because reviewers are under no obligation to view the Internet sites. Furthermore, we caution reviewers that their anonymity may be compromised when they directly access an Internet site. HEALTHY PEOPLE 2010: The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS-led national activity for setting priority areas. This RFA is related to one or more of the priority areas. Potential applicants may obtain a copy of "Healthy People 2010" at http://www.healthypeople.gov/. AUTHORITY AND REGULATIONS: This program is described in the Catalog of Federal Domestic Assistance at http://www.cfda.gov/ and is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement. The NIH Grants Policy Statement can be found at http://grants.nih.gov/grants/policy/policy.htm. The PHS strongly encourages all grant recipients to provide a smoke- free workplace and discourage the use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care, or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.


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