NIGMS' SUMMER RESEARCH EXPERIENCES FOR UNDERGRADUATES
RELEASE DATE: June 16, 2003
RFA: GM-03-010
CATALOG OF FEDERAL DOMESTIC ASSISTANCE NUMBER: 93.859
National Institute of General Medical Sciences (NIGMS)
(http://www.nigms.nih.gov/)
LETTER OF INTENT RECEIPT DATE: January 19, 2004
APPLICATION RECEIPT DATE: February 17, 2004
THIS RFA CONTAINS THE FOLLOWING INFORMATION
o Purpose of this RFA
o Research Objectives
o Mechanism(s) of Support
o Funds Available
o Eligible Institutions
o Individuals Eligible to Become Principal Investigators
o Special Requirements
o Where to Send Inquiries
o Letter of Intent
o Submitting an Application
o Peer Review Process
o Review Criteria
o Receipt and Review Schedule
o Award Criteria
o Required Federal Citations
PURPOSE OF THIS RFA
The National Institute of General Medical Sciences (NIGMS) recognizes
the increasing trend toward the use of interdisciplinary approaches to
advance the nation's biomedical research endeavor and thus the need to
encourage cross-disciplinary training for the next generation of
researchers. Therefore, this RFA seeks to encourage cross-training of
undergraduate students in the quantitative and physical sciences by
providing opportunities to take part in mentored research experiences
with NIH-supported biomedical investigators. Such programs should
provide innovative, mentored, realistic summer laboratory research
experiences for an appropriately targeted (as defined by the applicant)
group of undergraduate students in biomedical research projects at the
applicant institution. The proposed plan of undergraduate
interdisciplinary research training should include strong faculty
involvement, interactive group activities, presentations, and seminars.
Applications are sought for programs that recruit students from the
quantitative and physical disciplines such as, but not limited to,
engineering, mathematics, computer science, and physics, to participate
in biomedical and/or translational research.
RESEARCH OBJECTIVES
Background
This program seeks to promote the initiation and development of
distinct, innovative summer research experiences for a cohort of no
fewer than five and no more than ten undergraduate students who would
not normally be involved in the biomedical research endeavor. Programs
that recruit students from disciplines not traditionally involved in
biomedical research such as, but not limited to, engineering,
mathematics, computer science, and physics, to participate in
interdisciplinary biomedical and/or translational research are
especially encouraged.
Specific Objectives
The proposed summer program is expected to be specifically designed for
the undergraduate students majoring in 'non-biological' fields and
should promote their understanding of the need to apply quantitative
and related skills to solve biological questions. Development of
interest among prospective research scientists in interdisciplinary
approaches to biomedically related problems is the primary objective of
this summer apprenticeship program. The Program Director should be an
individual with the ability and authority to run an institutional,
cross-departmental program. Participating mentors should have active,
NIH extramurally funded research and preferably should have a
demonstrated record of student training. In addition, participating
mentors must be able to allocate sufficient time to mentor
undergraduate participants in the summer research experience program.
Additional information on NIGMS programs is available at the web site:
http://www.nih.gov/nigms/.
MECHANISM OF SUPPORT
This RFA will use the NIH education research project (R25) award
mechanism. As an applicant you will be solely responsible for
planning, directing, and executing the proposed project. This RFA is a
one-time solicitation. Future unsolicited applications will not be
accepted. The anticipated award date is February 2005.
This RFA uses just-in-time concepts. It also uses the non-modular
budgeting formats (see
https://grants.nih.gov/grants/funding/modular/modular.htm). This
program does not require cost sharing as defined in the current NIH
Grants Policy Statement at
https://grants.nih.gov/archive/grants/policy/nihgps_2001/part_i_1.htm.
FUNDS AVAILABLE
NIGMS intends to commit approximately $1.5 million in FY 2005 to fund
15 to 20 new or competing renewal applications. An applicant may
request a project period of up to four (4) years and a budget for
direct costs of up to $85,000 per year. Because the nature and scope
of the proposed research will vary from application to application, it
is anticipated that the size of each award will also vary, but an
applicant institution can only hold one award. Although the financial
plans of NIGMS provide support for this program, awards pursuant to
this RFA are contingent upon the availability of funds and the receipt
of a sufficient number of meritorious applications. At this time, it
is not known if this RFA will be reissued.
ELIGIBLE INSTITUTIONS
You may submit an application if your institution has any of the
following characteristics:
o Public or private non-profit domestic institutions, such as
universities, colleges, hospitals, and laboratories that have a cohort
of mentors with NIH or other extramural research support.
Foreign institutions are not eligible to apply.
INDIVIDUALS ELIGIBLE TO BECOME PRINCIPAL INVESTIGATORS
Any individual with the skills, knowledge, authority, and resources
necessary to carry out the proposed mentoring program for
undergraduates in research is invited to work with his/her institution
to develop an application for support. Individuals from
underrepresented racial and ethnic groups as well as individuals with
disabilities are always encouraged to apply for NIH programs.
SPECIAL REQUIREMENTS
Applicants should fully describe the proposed 'Summer Research
Experiences for Undergraduates' Program plan and explain how its design
will meet the goals of this initiative and the needs of the targeted
student group. Applicants should describe the criteria to be used in
the selection of students and their placement under the guidance of
specific mentors. A detailed description of potential laboratory
experiences as well as other enrichment activities planned for the
students must be included. The enrichment activities must provide the
students an understanding of basic biological concepts and of how
mathematics, physics, and computer science can assist in solving
biomedical research questions. Applicants should provide evidence of
previous experience, if any, in mentoring the targeted population. The
first week of the summer experience should also include instruction in
laboratory safety, discussions of ethical considerations in research,
and information on career options.
The applicants need also show evidence of the distinct nature of the
proposed summer program and a commitment to training the targeted pool.
Applicants with existing grants to provide summer research experiences
for undergraduates should describe the existing programs and explain
how they do not duplicate the proposed research experiences and goals
of the program designed under this initiative. Applicants can only
submit one grant proposal per institution.
NIGMS expects that students who enter a Summer Research Experiences for
Undergraduates Program will receive support from the institution
(grantee), i.e., access to equipment and library resources. Applicants
should describe the type(s) of institutional resources that would be
available for this program as well as a plan for monitoring student
activities to ensure that the program goals are being met.
Undergraduate students selected to participate in the summer programs
should be U.S. citizens or permanent residents.
Evaluation Requirements
Each application must include an evaluation plan that clearly
identifies measurable objectives, ascertains outcomes, and describes
the steps to assess effectiveness of the proposed activities. An
applicant should describe the current methods and facilities available
for tracking student participants and must provide details of the
methodology to be used to assess whether the program is meeting the
program's objectives.
Ideas on approaching evaluations of this type of program may be found
on http://www.the-aps.org/education/promote/promote.html. This site is
a project of the American Physiological Society that has received
support from NIGMS. Although it is targeted to the evaluation of
programs to increase the number of underrepresented minorities in
biomedical science, the material on this site may also be used as a
resource for developing evaluation plans for Summer Research
Experiences for Undergraduates Programs. For each noncompeting
renewal, the Program Director will report on evaluation of the impact
of the Summer Research Experiences for Undergraduates on the student
career choices in the participating departments.
Reporting Requirements
The Application for Continuation of a Grant (PHS 2590, rev. 5/01,
https://grants.nih.gov/grants/forms.htm) or equivalent documentation
must be submitted to, and be approved by, NIH to noncompetitively fund
each additional budget period within a previously approved project
period. The PHS 2590 (SNAP) application should include in the progress
report a list of students supported, description of the enrichment
activities provided, and a list of the mentors participating in the
summer research experience. The annual progress report must also
include information on how the proposed program objectives were
fulfilled (reference: NIH Grants Policy Statement, NIH Publication No.
99-8, October 1998). At the end of the approved project period, a
final report summarizing the accomplishments of the program (total
number of students that participated during the entire grant period and
the effect of their undergraduate research experiences on their current
career plans) must be submitted.
WHERE TO SEND INQUIRIES
We encourage inquiries concerning this RFA and welcome the opportunity
to answer questions from potential applicants. Inquiries may fall into
three areas: programmatic, peer review, and financial or grants
management issues:
o Direct inquiries regarding programmatic issues to:
Hinda Zlotnik, Ph.D.
Program Director, Summer Research Experiences for Undergraduates
National Institute of General Medical Sciences, NIH
45 Center Drive, Room 2AS.37K, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301)594-3900
FAX: (301)480-2753
E-mail: Zlotnikh@nigms.nih.gov
o Direct inquiries regarding review issues to:
Helen R. Sunshine, Ph.D.
Chief, Office of Scientific Review
National Institute of General Medical Sciences, NIH
45 Center Drive, Room 3AN.12F, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301)594-2881
FAX: (301)480-8506
E-mail: sunshinh@nigms.nih.gov
o Direct inquiries regarding fiscal matters to:
Antoinette Holland
Grants Management Officer
Division of Extramural Activities
National Institute of General Medical Sciences, NIH
45 Center Drive, Room 2AN.50, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301)594-5132
FAX: (301)480-2554
E-mail: hollanda@nigms.nih.gov
LETTER OF INTENT
Prospective applicants are asked to submit a letter of intent that
includes the following information:
o Descriptive title of the proposed summer program plan
o Name, address, and telephone number of the Program Director
o Names of other key personnel
o Participating institution(s)
o Number and title of this RFA
Although a letter of intent is not required, is not binding, and does
not enter into the review of a subsequent application, the information
that it contains allows NIGMS staff to estimate the potential review
workload and plan the review.
The letter of intent is to be sent by the date listed at the beginning
of this document. The letter of intent should be sent to:
Hinda Zlotnik, Ph.D.
Program Director, Summer Research Experiences for Undergraduates
National Institute of General Medical Sciences, NIH
45 Center Drive, Room 2AS.37K, MSC 6200
Bethesda, MD 20892-6200
Telephone: (301)594-3900
FAX: (301)480-2753
E-mail: Zlotnikh@nigms.nih.gov
SUBMITTING AN APPLICATION
Applications must be prepared using the PHS 398 research grant
application instructions and forms (rev. 5/2001). The PHS 398 is
available at https://grants.nih.gov/grants/funding/phs398/phs398.html in
an interactive format. For further assistance contact GrantsInfo,
Telephone (301) 710-0267, Email: GrantsInfo@nih.gov.
SUPPLEMENTAL INSTRUCTIONS
Allowable Costs:
If appropriate, the budget may include:
o Salary and Wages: (1) Student remuneration through salary, wages
and fringe benefits for participation in summer research experiences.
In order to provide student salary support, (a) students must perform
actual and meaningful research work; (b) an employer-employee
relationship must exist between the student and the institution; (c)
total compensation must be reasonable for the research work performed;
and (d) it must be the institution's practice to provide compensation
for all students in similar circumstances. Caution should be used not
to permit students to receive duplicate federal support (excluding Pell
Grants and VA Benefits). (2) Staff salaries and wages should be
limited to partial remuneration for the Program Director (no more than
10% effort) and an administrative assistant (no more than 25% effort).
A strong justification of their role in the project should be provided.
o Supplies and Other Expenses: The budget may include funds for
research supplies up to $750 per student.
Facilities and administration costs will be provided at a rate of 8%
minus exclusions.
Unallowable Costs:
o Include, but are not limited to: stipends, equipment, housing, food,
incentives, travel costs (e.g., to meetings or training sites),
textbooks, tuition, and entertainment costs. Consortium agreements
(related costs) are also unallowable.
USING THE RFA LABEL: The RFA label, available in the PHS 398 (rev.
5/2001) application form, must be affixed to the bottom of the face
page of the application. Type the RFA number on the label. Failure to
use this label could result in delayed processing of the application
such that it may not reach the review committee in time for review. In
addition, the RFA title and number must be typed on line 2 of the face
page of the application form and the YES box must be marked. The RFA
label is also available at:
https://grants.nih.gov/grants/funding/phs398/label-bk.pdf.
SENDING AN APPLICATION TO THE NIH: Submit a signed, typewritten
original of the application, including the Checklist, and three signed
photocopies, in one package to:
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040, MSC 7710
Bethesda, MD 20892-7710
Bethesda, MD 20817 (for express/courier service)
At the time of submission, two additional copies of the application
must be sent to:
Helen R. Sunshine, Ph.D.
Chief, Office of Scientific Review
National Institute of General Medical Sciences, NIH
45 Center Drive, Room 3AN.12F, MSC 6200
Bethesda, MD 20892-6200
APPLICATION PROCESSING: Applications must be received on or before the
application receipt date listed in the heading of this RFA. If an
application is received after that date, it will be returned to the
applicant without review.
Although there is no immediate acknowledgement of the receipt of an
application, applicants are generally notified of the review and
funding assignment within 8 weeks.
The Center for Scientific Review (CSR) will not accept any application
in response to this RFA that is essentially the same as one currently
pending initial review, unless the applicant withdraws the pending
application. The CSR will not accept any application that is
essentially the same as one already reviewed. This does not preclude
the submission of substantial revisions of applications already
reviewed, but such applications must include an Introduction addressing
the previous critique, describing the changes and improvements made,
and marked text to indicate the changes.
PEER REVIEW PROCESS
Upon receipt, applications will be reviewed for completeness by the CSR
and responsiveness by the NIGMS. Incomplete and/or non-responsive
applications will be returned to the applicant without further
consideration.
Applications that are complete and responsive to the RFA will be
evaluated for scientific and technical merit by an appropriate peer
review group convened by the NIGMS in accordance with the review
criteria stated below. As part of the initial merit review, all
applications will:
o Receive a written critique
o Undergo a process in which only those applications deemed to have
the highest scientific merit, generally the top half of the
applications under review, will be discussed and assigned a priority
score
o Receive a second level review by the NIGMS National Advisory
Council.
REVIEW CRITERIA
In their written comments, reviewers will be asked to discuss the
following aspects of the application in order to judge the likelihood
that the proposed summer research experience will have a substantial
impact on the pursuit of the stated program goals:
o Description of a distinct summer program that includes enrichment
activities in addition to mentored research experiences and provides
quantitatively trained students with the background needed to
understand and pursue biomedical research;
o Quality of the proposed summer program activities and likelihood
that they will provide a meaningful research experience for the
targeted population;
o Rationale for the selection procedures of the targeted student
population and evidence of adequate student pool;
o Qualifications and experience of the research faculty as
investigators and mentors, including evidence of adequate NIH-funded
support;
o Qualifications and experience of the program director to carry out
the proposed program;
o Merit of the measurable objectives and the plan for the evaluation
of the impact of the program;
o Evidence of institutional commitment; adequacy and availability of
research resources and the research environment;
o Cost-effectiveness of the project, appropriateness of the scope of
the program and its potential benefit to the students.
ADDITIONAL REVIEW CRITERIA: In addition to the above criteria, the
following items will be considered in the determination of scientific
merit and priority score:
PROTECTION OF HUMAN SUBJECTS FROM RESEARCH RISK: The involvement of
human subjects and protections from research risk relating to their
participation in the proposed research will be assessed. (See criteria
included in the section on Federal Citations, below.)
INCLUSION OF WOMEN, MINORITIES AND CHILDREN IN RESEARCH: The adequacy
of plans to include subjects from both genders, all racial and ethnic
groups (and subgroups), and children as appropriate for the scientific
goals of the research. Plans for the recruitment and retention of
subjects will also be evaluated. (See Inclusion Criteria in the
sections on Federal Citations, below.)
CARE AND USE OF VERTEBRATE ANIMALS IN RESEARCH: If vertebrate animals
are to be used in the project, the five items described under Section f
of the PHS 398 research grant application instructions (rev. 5/2001)
will be assessed.
ADDITIONAL CONSIDERATIONS
DATA SHARING: The adequacy of the proposed plan to share data.
BUDGET: The reasonableness of the proposed budget.
RECEIPT AND REVIEW SCHEDULE
Letter of Intent Receipt Date: January 19, 2004
Application Receipt Date: February 17, 2004
Peer Review Date: June/July 2004
Council Review: September/October 2004
Earliest Anticipated Start Date: February 1, 2005
AWARD CRITERIA
Award criteria that will be used to make award decisions include:
o Scientific merit (as determined by peer review)
o Programmatic priorities
o Geographical distribution of awardee institutions
o Availability of funds
REQUIRED FEDERAL CITATIONS
HUMAN SUBJECTS PROTECTION: Federal regulations (45CFR46) require that
applications and proposals involving humans subjects be evaluated with
reference to the risks to the subjects, the adequacy of the protection
against these risks, the potential benefits of the research to the
subjects and others, and the importance of the knowledge gained or to
be gained.
http://www.hhs.gov/ohrp/humansubjects/guidance/45cfr46.htm
INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH: It is the
policy of the NIH that women and members of minority groups and their
sub-populations must be included in all NIH-supported clinical research
projects unless a clear and compelling justification is provided
indicating that inclusion is inappropriate with respect to the health
of the subjects or the purpose of the research. This policy results
from the NIH Revitalization Act of 1993 (Section 492B of Public Law
103-43).
All investigators proposing clinical research should read the "NIH
Guidelines for Inclusion of Women and Minorities as Subjects in
Clinical Research - Amended, October, 2001," published in the NIH Guide
for Grants and Contracts on October 9, 2001
(https://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-001.html); a
complete copy of the updated Guidelines are available at
https://grants.nih.gov/grants/funding/women_min/guidelines_amended_10_2001
.htm. The amended policy incorporates: the use of an NIH definition
of clinical research; updated racial and ethnic categories in
compliance with the new OMB standards; clarification of language
governing NIH-defined Phase III clinical trials consistent with the new
PHS Form 398; and updated roles and responsibilities of NIH staff and
the extramural community. The policy continues to require for all NIH-
defined Phase III clinical trials that: a) all applications or
proposals and/or protocols must provide a description of plans to
conduct analyses, as appropriate, to address differences by sex/gender
and/or racial/ethnic groups, including subgroups if applicable; and b)
investigators must report annual accrual and progress in conducting
analyses, as appropriate, by sex/gender and/or racial/ethnic group
differences.
INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN
SUBJECTS: The NIH maintains a policy that children (i.e., individuals
under the age of 21) must be included in all human subjects research,
conducted or supported by the NIH, unless there are scientific and
ethical reasons not to include them. This policy applies to all initial
(Type 1) applications submitted for receipt dates after October 1, 1998.
All investigators proposing research involving human subjects should
read the "NIH Policy and Guidelines" on the inclusion of children as
participants in research involving human subjects that is available at
https://grants.nih.gov/grants/funding/children/children.htm
REQUIRED EDUCATION ON THE PROTECTION OF HUMAN SUBJECT PARTICIPANTS:
NIH policy requires education on the protection of human
subject participants for all investigators submitting NIH proposals for
research involving human subjects. You will find this policy
announcement in the NIH Guide for Grants and Contracts Announcement,
dated June 5, 2000, at https://grants.nih.gov/grants/guide/notice
-files/NOT-OD-00-039.html.
HUMAN EMBRYONIC STEM CELLS (hESC): Criteria for federal funding of
research on hESCs can be found at
http://stemcells.nih.gov/index.asp and at
https://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-005.html.
Only research using hESC lines that are registered in the NIH Human
Embryonic Stem Cell Registry will be eligible for Federal funding (see
http://escr.nih.gov). It is the responsibility of the applicant to
provide the official NIH identifier(s)for the hESC line(s)to be used in
the proposed research. Applications that do not provide this
information will be returned without review.
PUBLIC ACCESS TO RESEARCH DATA THROUGH THE FREEDOM OF INFORMATION ACT:
The Office of Management and Budget (OMB) Circular A-110 has been
revised to provide public access to research data through the Freedom
of Information Act (FOIA) under some circumstances. Data that are (1)
first produced in a project that is supported in whole or in part with
Federal funds and (2) cited publicly and officially by a Federal agency
in support of an action that has the force and effect of law (i.e., a
regulation) may be accessed through FOIA. It is important for
applicants to understand the basic scope of this amendment. NIH has
provided guidance at
https://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm.
Applicants may wish to place data collected under this RFA in a public
archive, which can provide protections for the data and manage the
distribution for an indefinite period of time. If so, the application
should include a description of the archiving plan in the study design
and include information about this in the budget justification section
of the application. In addition, applicants should think about how to
structure informed consent statements and other human subjects
procedures given the potential for wider use of data collected under
this award.
STANDARDS FOR PRIVACY OF INDIVIDUALLY IDENTIFIABLE HEALTH INFORMATION:
The Department of Health and Human Services (DHHS) issued final
modification to the "Standards for Privacy of Individually Identifiable
Health Information", the "Privacy Rule," on August 14, 2002. The
Privacy Rule is a federal regulation under the Health Insurance
Portability and Accountability Act (HIPAA) of 1996 that governs the
protection of individually identifiable health information, and is
administered and enforced by the DHHS Office for Civil Rights (OCR).
Those who must comply with the Privacy Rule (classified under the Rule
as "covered entities") must do so by April 14, 2003 (with the exception
of small health plans which have an extra year to comply).
Decisions about applicability and implementation of the Privacy Rule
reside with the researcher and his/her institution. The OCR website
(http://www.hhs.gov/ocr/) provides information on the Privacy Rule,
including a complete Regulation Text and a set of decision tools on "Am
I a covered entity?" Information on the impact of the HIPAA Privacy
Rule on NIH processes involving the review, funding, and progress
monitoring of grants, cooperative agreements, and research contracts
can be found at https://grants.nih.gov/grants/guide/
notice-files/NOT-OD-03-025.html.
URLs IN NIH GRANT APPLICATIONS OR APPENDICES: All applications and
proposals for NIH funding must be self-contained within specified page
limitations. Unless otherwise specified in an NIH solicitation,
Internet addresses (URLs) should not be used to provide information
necessary to the review because reviewers are under no obligation to
view the Internet sites. Furthermore, we caution reviewers that their
anonymity may be compromised when they directly access an Internet
site.
HEALTHY PEOPLE 2010: The Public Health Service (PHS) is committed to
achieving the health promotion and disease prevention objectives of
"Healthy People 2010," a PHS-led national activity for setting priority
areas. This RFA is related to one or more of the priority areas.
Potential applicants may obtain a copy of "Healthy People 2010" at
http://www.health.gov/healthypeople.
AUTHORITY AND REGULATIONS: This program is described in the Catalog of
Federal Domestic Assistance at http://www.cfda.gov/ and is not subject
to the intergovernmental review requirements of Executive Order 12372
or Health Systems Agency review. Awards are made under the
authorization of Sections 301 and 405 of the Public Health Service Act
as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR 52
and 45 CFR Parts 74 and 92. All awards are subject to the terms and
conditions, cost principles, and other considerations described in the
NIH Grants Policy Statement. The NIH Grants Policy Statement can be
found at https://grants.nih.gov/grants/policy/policy.htm.
The PHS strongly encourages all grant recipients to provide a smoke-
free workplace and discourage the use of all tobacco products. In
addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits
smoking in certain facilities (or in some cases, any portion of a
facility) in which regular or routine education, library, day care,
health care, or early childhood development services are provided to
children. This is consistent with the PHS mission to protect and
advance the physical and mental health of the American people.