NATIONAL RESEARCH SERVICE AWARD - INSTITUTIONAL TRAINING AWARDS

Release Date:  August 14, 1998

RFA:  DE-98-010

P.T.

National Institute of Dental Research

Letter of Intent Receipt Date:  October 1, 1998
Application Receipt Date:  October 22, 1998

PURPOSE

The National Institute of Dental Research (NIDR) invites new and competing
continuation applications proposing National Research Service Award (NRSA)
Institutional Research Training Grant (T32) programs.  The objectives are to: 
(a) develop highly qualified investigators in dental, craniofacial and oral
health research, especially clinician scientists, by supporting postdoctoral
training of individuals with a health professional degree who are committed to
a research career in the basic biomedical, behavioral and clinical sciences,
(b) provide re-training opportunities for mid-career scientists and clinical
researchers to obtain expertise in particular basic or behavioral sciences
relevant to the NIDR areas of research emphasis, and (c) train predoctoral and
early post-Ph.D. biomedical and behavioral scientists interested in oral,
dental and craniofacial health and disease.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health promotion
and disease prevention objectives of "Healthy People 2000," a PHS-led national
activity for setting priority areas.  This Request for Applications (RFA),
NRSA - Institutional Training Awards, is related to the priority area of oral
health.  Potential applicants may obtain a copy of "Healthy People 2000" (Full
Report: Stock No. 017-001-00474-0 or Summary Report: Stock No.017-001-00473-1)
through the Superintendent of Documents, Government Printing Office,
Washington, DC 20402-9325 (telephone 202/512-1800).

ELIGIBILITY REQUIREMENTS

Domestic public and private institutions, such as dental or medical schools
and research institutions, may submit applications.  The applicant institution
must have a strong research program in the area(s) proposed for research
training and must have the requisite staff and facilities to carry out the
proposed program.  Local collaborations or regional consortia are encouraged
where relevant to the field of training being offered and feasible to
establish.  This is especially important for programs which provide training
in interdisciplinary fields, such as biomimetics and tissue engineering,
molecular epidemiology, bioinformatics and behavioral medicine.

Only one application may be submitted by an institution, unless the proposed
training programs are in distinctly different areas of dental, craniofacial
and oral health and disease.

Levels of Training and Trainee Eligibility

Training in an NIDR area of scientific opportunity is to be provided at one or
more of the following levels: (1) dentists, physicians or other health
professionals pursuing training in postdoctoral clinical or patient-oriented
research, (2) mid-career scientists and clinical researchers who wish to re-
train in a basic or behavioral science area related to craniofacial, dental
and oral health and disease, (3) baccalaureate degree holders pursuing a Ph.D.
or equivalent degree, (4) dentists wishing to pursue a Ph.D. or equivalent
degree in a basic biomedical or behavioral science, although these individuals
are encouraged to enter an Institutional Dentist Scientist Award program if
they also desire to obtain training in a clinical specialty, and (5) Ph.D.
degree holders pursuing postdoctoral research training, although generally
they are expected to apply for an individual postdoctoral NRSA fellowship (F32
mechanism).

Preference should be given to post-doctoral trainees who have received, as of
the beginning of an appointment, a dental or medical degree from an accredited
domestic or foreign institution. If the degree has not yet been conferred, a
statement, by an authorized official of the degree-granting institution, that
all degree requirements have been met is acceptable.

Predoctoral trainees must have received a baccalaureate degree as of the
beginning of the appointment and be enrolled in a graduate program leading to
the award of a Ph.D. or an equivalent degree in biomedical or behavioral oral
health research.

Individuals who wish to interrupt their professional school studies for one or
more years to engage in full-time research training before completing their
professional degrees are eligible, however, prior approval by the NIDR, as
well as by the institution, is required before an appointment can be offered.

Short-term predoctoral research training positions cannot be requested through
this RFA. Instead, these types of positions must be supported through NRSA
Short-Term Institutional Training grants (T35 mechanism).

Trainees must be citizens or noncitizen nationals of the United States, or
have been lawfully admitted for permanent residence and possess an Alien
Registration Receipt Card (I-551) or other legal verification of such status.
Noncitizen nationals, although not citizens of the United States, owe
permanent allegiance to the U.S. They are generally born in lands which are
not states but are under U.S. sovereignty, jurisdiction, or administration.
Individuals on temporary or student visas are not eligible.

MECHANISM OF SUPPORT

Awards resulting from this RFA will be the NRSA Institutional Research
Training Grants (T32).  Responsibility for the planning, direction, and
execution of the proposed project will be solely that of the applicant.  The
total project period for each application submitted in response to this RFA
may not exceed five years.  Awards may be renewable upon submission of a
successful competing continuation application, depending on programmatic needs
and the availability of funds.  The anticipated award date is July 1, 1999.

Trainees may receive up to five years of NRSA support at the predoctoral level
and three years of support at the postdoctoral level, including any
combination of support from institutional training awards and individual
fellowship awards.  Extensions beyond these periods require a waiver from the
NIH.  It is expected that postdoctoral trainees with PhD, DDS./DMD, MD or
equivalent degrees will engage in not less than two years training.  However,
those mid-career scientists and clinical researchers who seek re-training in
basic or behavioral science research can spend between one to two years in the
program, depending on the desired level of expertise to be obtained and the
period of time allowed by their home institutions for sabbatical or leave-of-
absence.

FUNDS AVAILABLE

The NIDR expects to make up to five new or competing continuation awards. 
Each new program will have two positions in the first year.  Existing programs
may request an appropriate number of positions to maintain current trainees. 
The estimated total funding for all awards is $500,000 in the first year. This
level of support is dependent on the receipt of a sufficient number of
applications of high scientific and educational merit and availability of
adequate NIDR funds.

RESEARCH OBJECTIVES

Background

The primary goal of NIDR programs is to improve the dental, craniofacial and
oral health of the American people.  To attain this goal, the NIDR plans to
pursue scientific opportunities in such areas as functional genomics,
developmental biology, emerging and re-emerging infectious diseases, oral
neoplastic diseases, tissue engineering, biomimetics and biomaterials,
connective and skeletal tissue regeneration, basic and clinical pain, sensory,
swallowing, taste and smell disorders, chronic disabling conditions associated
with the oral/craniofacial region, relationships between oral and other
systemic diseases, clinical trials, clinical outcomes and improved treatment,
disease prevention, behavior and health promotion.  More detailed information
about these areas can be found on the NIDR Home Page at: 
http://www.nidr.nih.gov/research/extramural/sciprog.htm.  Most, if not all, of
the scientific opportunities involve multidisciplinary research, which
requires teams of scientists from different fields and often utilizes multi-
institutional collaborations.  The relevance of this theme was emphasized at a
planning workshop, "Scientific Opportunities and Research Capacity in the
Coming Millennium," held by the NIDR in January 1998.  The report can be
accessed on the Internet at http://www.nidr.nih.gov/news/strat-
plan/millenwkshp.htm. A key recommendation from the workshop was that future
research training and career development programs should emphasize
"multidisciplinary training approaches, translational research capacity and
flexible training paradigms."  Trainees should leave with an appreciation and
understanding of the integration between biological and behavioral systems and
the ability to work in teams on complex research problems.  Health research
should be viewed "as part of the larger biomedical research enterprise and
training programs should be designed to promote interaction between oral-
dental-craniofacial health researchers and other biomedical and behavioral or
social scientists."  A particular deficiency among current biomedical
scientists is in the area of translational research, which serves to link
bench laboratory results and patientsþ needs by facilitating the application
of basic science findings to clinical care.  To meet the future needs, there
should be a variety of training paradigms according to the types of
investigators required and possible alternative strategies for developing
their investigative capabilities.  Therefore, to offer the most appropriate
training for future basic and clinical scientists, applicants for NRSA
institutional training programs are encouraged to consider developing, as
deemed necessary, interdisciplinary collaborations among various components of
their health science center (e.g., dental, medical, public health and graduate
school) as well as with other regional academic institutions and private
industry so that trainees are provided the strongest and most relevant
background for the particular research area they wish to pursue.

The NIDR has a strong interest in the training of individuals who will be able
to engage in clinical research studies, including clinical trials. Several
NIDR and NIH advisory groups and reports from the Institute of Medicine and
National Research Council, National Academy of Sciences, have called attention
to the need to expand the pool of clinical and patient-oriented investigators
in order to take advantage of opportunities for translation and transfer of
fundamental knowledge to improve the publicþs oral health care.   Patient-
oriented research is defined as "research conducted with human subjects (or on
material of human origin such as tissues, specimens and cognitive phenomena)
for which an investigator (or colleague) directly interacts with human
subjects." This type of research includes such topics as: the development and
evaluation of new diagnostic and therapeutic technologies, techniques and
devices, mechanisms of human disease and the characterization of normal and
diseased function, therapeutic interventions and clinical drug trials, and
patient compliance and disease prevention regimens.  For example, programs on
aspects of clinical research methods, including design of clinical trials and
data analysis, could be developed for junior faculty in clinical departments,
especially those who have recently completed advanced specialty training.

There is a pool of mid-career oral health researchers, including basic and
behavioral scientists and clinical investigators, who may wish to update their
scientific expertise and keep current with the rapid knowledge developments in
science.  It is important to provide some re-training mechanism that would
enable these individuals to remain viable, active, contributing members of the
scientific research community. Additional training also would be relevant for
scientists who desire to change their scientific focus and redirect their
research efforts toward dental, oral and craniofacial health and disease.

Objectives and Scope

The training program must provide opportunities for individuals to carry out
supervised biomedical, behavioral or clinical research and develop research
skills in an area related to dental, oral and craniofacial health and disease.
Clinical research programs must have strong relationships with basic or
behavioral scientists to ensure that trainees will have the opportunity to
acquire the necessary foundation for independent investigation.  As necessary,
interdisciplinary approaches and multi-institutional collaborations should be
utilized in the research training program to prepare investigators for the
probable structure of most future scientific endeavors.

The training program director will be responsible for the selection and
appointment of trainees and for the overall direction of the program.

Applicants can request no more than six postdoctoral or three predoctoral
positions in any year.  For new programs, it is appropriate to have two new
appointments in each of the first, second, and third years. In order to
address the need for clinical investigators, applicants must allocate not less
than two postdoctoral positions during the five years of the program to
individuals with a declared interest in receiving training to conduct patient-
oriented research. The remaining postdoctoral positions may be used for basic,
behavioral or clinical research trainees in any of the research areas relevant
to the mission of the NIDR. Several of these positions should be employed
during the duration of the program for re-training mid-career scientists. The
number and types of positions awarded will be determined by the initial review
group"s assessment of scientific and educational merit, program needs, and the
availability of funds.

Training grants may not be used to support studies leading to dental, medical,
or other similar professional degrees, or to support residencies, or other
training for dentists providing care to patients where the majority of their
time is spent in non-research clinical training. However, if a specified
period of full-time research training is creditable toward specialty board
certification, the training grant may support such research training if the
trainee has shown a clear interest in a research career. Those dental students
interested in pursuing the DDS/DMD and PhD in a joint effort should consider
applying for the NRSA Individual Predoctoral Dental Scientist Fellowship, or
F30 award.  Information about this can be accessed in the NIH Guide on the
Internet at:  http://grants.nih.gov/grants/guide/pa-files/PAR-97-094.html.

Applicants are reminded of the importance the NIDR places on recruitment and
retention of women and underrepresented minorities to sponsored training and
career development programs.  Where feasible women and minority mentors should
be involved as role models.

Stipends and Other Training Costs

For predoctoral trainees at all levels of experience, the current stipend is
$11,748 per year.

For postdoctoral trainees, stipends are provided as a subsistence allowance to
help defray living expenses during the research training experience. The
stipend is not provided as a condition of employment with either the Federal
Government or the sponsoring institution. Stipend level for the first year of
NRSA support is determined by the number of FULL years of relevant
postdoctoral experience at the time of appointment. Relevant experience may
include research activities (including industrial), teaching, internship,
residency, clinical duties, or other time spent in a health-related field
beyond that of the qualifying doctoral degree. The current postdoctoral
stipend levels are as follows:

Years of Relevant Experience                          Stipend

less than 1                                           $21,000
greater than or equal to 1 but less than 2            $22,176
greater than or equal to 2 but less than 3            $26,160
greater than or equal to 3 but less than 4            $27,492
greater than or equal to 4 but less than 5            $28,824
greater than or equal to 5 but less than 6            $30,144
greater than or equal to 6 but less than 7            $31,476
greater than or equal to 7                            $33,012

The stipend for each subsequent year of NRSA support is the next level in the
stipend structure and begins on the anniversary appointment date. No departure
from the standard stipend schedule may be negotiated between the institution
and trainee.

Stipend Supplementation. Supplementation or additional support to offset the
cost of living may be provided by the grantee institution. Supplementation
does not require any additional effort from the trainee. Federal funds may not
be used for supplementation unless specifically authorized under the terms of
both the program from which such supplemental funds are to be received and the
program whose funds are to be supplemented. Under no circumstances may DHHS
funds be used for supplementation.

Compensation.

An institution may provide additional funds to a trainee in the form of
compensation (as salary and/or tuition remission) for services such as
teaching or serving as a research assistant. A trainee may receive
compensation for services as a research assistant or in some other position on
a Federal research grant, including a DHHS research grant.  However,
compensated services should occur on a limited, part-time basis apart from the
normal research training activities, which require a minimum of 40 hours per
week. In addition, compensation may not be paid from a research grant
supporting research that is part of the research training experience.

Under no circumstances may the conditions of stipend supplementation or the
services provided for compensation interfere with, detract from, or prolong
the trainee"s approved NRSA training program.

Educational Loans or G.I. Bill

An individual may make use of Federal educational loan funds and assistance
under the Veterans Readjustment Benefits Act (G.I. Bill).  Such funds are not
considered supplementation or compensation.

Tuition, Fees, and Health Insurance

Tuition, fees, and self-only medical insurance, are allowable trainee costs if
such charges are required of all individuals in a similar training status at
the institution, regardless of their source of support.  Family medical
insurance coverage is not an appropriate charge to the NRSA research training
grant.  Tuition at the postdoctoral level is limited to that required for
specific courses in support of the approved research training program. On an
annual basis, for each trainee, the training grant will cover 100% of the
first $2,000 of the combined cost of tuition, fees, and self-only health
insurance and 60% of any amount above $2,000.  Institutions are instructed to
request the full amount of these costs in competing applications. 
Noncompeting awards will reimburse tuition, fees, and health insurance costs
in the amount paid in the previous award year, unless there is a change in the
scope of the award

Other Trainee Costs

Trainee travel, including attendance at scientific meetings that the
institution determines to be necessary to the individual"s training, is an
allowable trainee cost in the amount of $800 per year per trainee.

Institutional costs of $1,500 per year per predoctoral trainee and $2,500 per
year per postdoctoral trainee may be requested to defray the cost of training
related expenses, such as staff salaries, consultant costs, equipment,
research supplies, and staff travel.

A facilities and administration allowance (indirect cost allowance) based on 8
percent of total allowable direct costs (this excludes amounts for tuition,
fees, health insurance, and equipment) may be requested. Applications from
State and local government agencies may request full indirect cost
reimbursement (see PHS Grants Policy Statement).

Payback Provisions

Postdoctoral trainees must complete and sign a Payback Agreement Form (PHS
6031) to fulfill the NRSA payback requirement when they are appointed
initially to a research training grant. Postdoctoral trainees in the first
twelve months of NRSA support incur one month of obligation for each month of
support. Postdoctoral trainees in the thirteenth and subsequent months of NRSA
support are not required to sign the Payback Agreement Form and do not incur a
service payback obligation. The thirteenth and subsequent months of
postdoctoral NRSA support are considered acceptable payback service for prior
postdoctoral support. Individuals appointed to their initial NRSA postdoctoral
period in a project funded in response to this RFA and who continue under that
award for two years have fulfilled their obligation by the end of their second
year. Service payback obligations also can be paid back by conducting
biomedical or health-related behavioral research, teaching in a health
professional school, college, or high school, or engaging in additional
research training for more than 20 hours per week for a period equal to the
period of support, up to 12 months. Clinical practice and administrative
responsibilities not directly related to scientific research are unacceptable
for payback service.

Postdoctoral NRSA recipients must begin to undertake any remaining obligated
service on a continuous basis within two years after termination of NRSA
support. The period for undertaking payback service may be delayed for such
reasons as temporary disability, completion of residency requirements, or
completion of the requirements for a graduate degree. Requests for an
extension must be made in writing to the Division of Extramural Research,
NIDR, specifying the need for additional time and the length of the required
extension. Recipients of NRSA support are responsible for informing the
Division of Extramural Research, NIDR, of changes in status and address.
Individuals who fail to fulfill the obligation through service must payback
the total amount of funds paid to the individual for the obligation period
plus interest at a rate determined by the Secretary of the Treasury. Financial
payback must be completed within three years of the date the United States
becomes entitled to recover such amount. Under certain conditions, the
Secretary of Health and Human Services may extend the period for starting
service or for repayment, permit breaks in the period of service or repayment,
or otherwise waive or suspend the payback obligation of an individual.

Officials of the applicant organization responsible for recruitment of
trainees should familiarize themselves with the terms of the payback service
requirement and explain them carefully to prospective trainees before an
appointment to the training grant is offered.

For additional information on aspects of the Institutional NRSA such as
payback provisions, trainee reporting requirements, leave, stipends, tax
liability and the grounds for approving extensions of support and payback
provisions, refer to the notice "NIH National Research Service Award
Institutional Research Training," which is available in the NIH Guide for
Grants and Contracts,  Vol. 26, No. 16, May 16, 1997.  This can be accessed on
the Internet at:
http://grants.nih.gov/grants/guide/notice-files/not97-007.html.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of the NIH that women and members of minority groups and
their subpopulations must be included in all NIH supported biomedical and
behavioral research projects involving human subjects, unless a clear and
compelling rationale and justification is provided that inclusion is
inappropriate with respect to the health of the subjects or the purpose of the
research.  This policy results from the NIH Revitalization Act of 1993
(Section 492B of Public Law 103A3).  All investigators proposing research
involving human subjects should read the "NIH Guidelines for Inclusion of
Women and Minorities as Subjects in Clinical Research," which have been
published in the Federal Register of March 28, 1994 (FR 59 14508-14513) and in
the NIH Guide for Grants and Contracts, Volume 23, Number 11, March 18,1994.

Investigators also may obtain copies of the policy from the program staff
listed under INQUIRIES.  Program staff may also provide additional relevant
information concerning the policy.

NIH POLICY AND GUIDELINES ON THE INCLUSION OF CHILDREN AS PARTICIPANTS IN
RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research conducted or supported by NIH
unless there are scientific and ethical reasons not to include them.  This
policy applies to all initial (Type 1) applications submitted for receipt
dates after October 1, 1998.

All investigators proposing research involving human subjects should read the
"NIH Policy and Guidelines on the Inclusion of Children as Participants in
Research Involving Human Subjects" that was published in the NIH Guide for
Grants and Contracts, March 6, 1998 and is available at: 
http://grants.nih.gov/grants/guide/notice-files/not98-024.html

LETTER OF INTENT

Prospective applicants are asked to submit, by October 1, 1998, a letter of
intent that includes a descriptive title of the proposed research training
program, the name, address, and telephone number of the program director, the
identities of other key personnel and participating institutions, and the
number and title of the RFA in response to which the application may be
submitted.

Although a letter of intent is not required, is not binding, and does not
enter into the review of subsequent applications, the information that it
contains is helpful in planning for the review of applications.  It allows
NIDR staff to estimate the potential review workload and to avoid conflicts of
interest in the review.

The letter of intent is to be sent to Dr. James A. Lipton at the address
listed under INQUIRIES.

APPLICATION PROCEDURES

It is strongly recommended that prospective applicants contact Dr. Lipton
early in the planning phase of application preparation.  The research grant
application form PHS 398 (rev. 5/95) is to be used in applying for these
grants.  These forms are available at most institutional offices of sponsored
research and from the Division of Extramural Outreach and Information
Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910,
Bethesda, MD 20892-7910, telephone 301/435-0714, email GrantsInfo@nih.gov. 
Applications kits are also available on the web at: 
http://grants.nih.gov/grants/funding/phs398/phs398.html

For competitive continuation applications, cumulative information on the
career development of all former trainees, including information about their
minority and gender status, must be included.  For new applications, data
should be provided about the career accomplishments of individuals who have
completed research training programs at the institution(s) within the past
five to ten years.

Applications must include a description of formal and or informal activities
related to instruction about the responsible conduct of research to be
incorporated into the proposed research training program.  Information must be
provided on the rationale, subject matter, appropriateness, format, frequency,
and duration of instruction, and the amount and nature of faculty
participation.  Progress reports in competing and non-competing continuation
applications must include the type of instruction, topics covered, and other
details, such as attendance by trainees and names of the instructors. No award
will be made if an application lacks this component.

The RFA label available in the application form PHS 398 must be affixed to the
bottom of the face page. Failure to use this label could result in delayed
processing of the application such that it may not reach the review committee
in time for review.  In addition, the RFA title (NRSA - Institutional Training
Awards) and number (DE-98-010) must be typed on line 2 of the face page of the
application and the YES box must be marked.

Submit a signed, typewritten original of the application including the
Checklist and three signed, photocopies, in one package to:

CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040, MSC-7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817-7710 (for express/courier service)

At the time of submission, two additional copies of the application also must
be sent to:

H. George Hausch, Ph.D.
Division of Extramural Research
National Institute of Dental Research
Natcher Building, Room 4AN.44F
Bethesda, MD  20892-6402
Telephone:  (301) 594-2372

This RFA is for a single competition.  Applications must be received by
October 22, 1998.  If an application is received after that date it will be
returned to the applicant without review.  The Center for Scientific Review
(CSR) will not accept any application that is essentially the same as one
already reviewed.  This does not preclude the submission of substantial
revisions of applications already reviewed, but such applications must include
an introduction addressing the previous critique.

REVIEW CONSIDERATIONS

Applications will be reviewed for completeness by CSR and responsiveness to
the RFA by NIDR staff. Incomplete and/or nonresponsive applications will be
returned to the applicant without further consideration.  Applications that
are complete and responsive to the RFA will be evaluated for scientific and
technical merit by an appropriate peer review group convened by the NIDR in
accordance with the standard NIH peer review procedures.  As part of the
initial merit review, all applications will receive a written critique and
undergo a process in which only those applications deemed to have the highest
scientific merit, generally the top half of applications under review, will be
discussed, assigned a priority score, and receive a second level review by the
National Advisory Dental Research Council.

The following review criteria are applicable to both new and competing
continuation applications:

Clarity and quality of the program objectives and design.  Training programs
should focus on scientific opportunities in the NIDR emphasis areas, as
delineated under Background.  In addition, trainees should be able to at least
learn about, if not participate in, multidisciplinary research and
interdisciplinary collaborations through a well-structured team approach.

Research experience and mentoring accomplishments of the program director,
especially his/her record as a recipient of peer-reviewed research grants and
as a mentor of basic, behavioral or clinical research scientists,

Caliber of preceptors as researchers, including successful competition for
grant support and as mentors of junior scientists,

The institutional training environment, including the level of institutional
commitment, quality of the facilities, availability of appropriate courses,
and availability of research support,

Recruitment and selection plans for trainees and the availability of high
quality candidates, especially mid-career basic or behavioral scientists,
clinical research investigators, underrepresented minorities and women.

When appropriate, the concomitant research training of health-professional
postdoctorates (i.e., individuals having the DDS M.D., D.O., etc.) with basic
science  postdoctorates (i.e., individuals with a Ph.D. or equivalent) or
linkages with basic science  departments.

For competing continuation applications, the following additional criteria
will be considered:

Past research training record of both the program and the designated
preceptors as determined by the success of former trainees in seeking further
career development and in establishing productive scientific careers. 
Evidence of further career development can include receipt of postdoctoral
fellowships, mentored clinical career development (K mechanism) awards,
further training appointments and similar accomplishments.  Evidence of a
productive scientific career can include a record of successful competition
for research grants, receipt of special honors, a record of publications,
receipt of patents, promotion to scientific positions and any other measure of
success consistent with the nature and duration of the training received.

Record of the program in retaining health-professional postdoctoral trainees
for at least 2 years in research training or other research activities.

For new applications, additional criteria are:

Career accomplishments of individuals who have completed research training
programs at the institution during the past five to ten years,

Potential recruitment pools for trainees.

Additional Review Considerations
1) Minority Recruitment Plan:

The NIH remains committed to increasing the participation of individuals from
underrepresented minority groups in biomedical and behavioral research.  As
first announced in 1989, all competing applications for institutional NRSA
research training grants must include a specific plan to recruit and retain
underrepresented minorities in the training program.  In addition, all
competing continuation applications must include a report on the recruitment
and retention of underrepresented minorities during the previous award period. 
If an application is received without a plan, or without a report on the
previous award period, the application will be considered incomplete and will
be returned to the applicant without review.  Additional information on this
requirement was published in the NIH Guide for Grants and Contracts, Vol. 22,
No. 25, July 16, 1993 (http://grants.nih.gov/grants/guide/notice-files/not93-188.html).

As indicated above, competing continuation applications must include a
detailed account of experiences in recruiting individuals from
underrepresented groups during the previous award period.  Information must be
included on successful and unsuccessful recruitment strategies.  The report
should provide information on the racial/ethnic distribution of:

o  Students or postdoctorates who applied for admission or positions within
the department(s) relative to the training grant,

o  Students or postdoctorates who were offered admission to or a position
within the department(s),

o  Students actually enrolled in the academic program relevant to the training
grant,

o  Students or postdoctorates who were appointed to the research training
grant.

For those minority trainees who were appointed to the grant, the report should
include information about the duration of research training and whether those
trainees have finished training in good standing.

Where applicable, new applications should include relevant information about
the above topics for previous or ongoing basic, behavioral or clinical
research training programs at their institution.

After the overall educational and technical merit of an application has been
assessed, peer reviewers will examine and evaluate the minority recruitment
plan and any record of recruitment and retention. For competing continuation
applications, the reviewers will examine and evaluate the record of the
program in recruiting and retaining underrepresented minority trainees during
the previous award period. The panel also will consider whether the experience
in recruitment during the previous award period has been incorporated into the
formulation of the recruitment plan for the next award period. The findings of
the panel will be included in an administrative note in the summary statement.
If the minority recruitment plan or if the record of recruitment and retention
of minorities is judged to be unacceptable, funding will be withheld until a
revised plan that addresses the deficiencies is received. Staff within the NIH
awarding component, with guidance from the appropriate national advisory
committee or council, will determine whether amended plans and reports
submitted after the initial review are acceptable.

Training in the Responsible Conduct of Research:

Every predoctoral and postdoctoral NRSA trainee supported by an institutional
research training grant must receive instruction in the responsible conduct of
research. (For more information on this provision, see the NIH Guide for
Grants and Contracts, Volume 21, Number 43, November 27,1992.) Applications
must include a description of a program to provide formal or informal
instruction in scientific integrity or the responsible conduct of research.
Applications without plans for instruction in the responsible conduct of
research will be considered incomplete and may be returned to the applicant
without review. NIH initial review groups will assess the applicantþs plans on
the basis of the appropriateness of topics, format, amount and nature of
faculty participation, and the frequency and duration of instruction. The plan
will be discussed after the overall determination of merit, so that the
quality of the plan will not be a factor in the determination of the priority
score.  Plans will be judged as acceptable or unacceptable.  The acceptability
of the plan will be described in an administrative note on the summary
statement.  Regardless of the priority score, applications with unacceptable
plans will not be funded until a revised, acceptable plan is provided by the
applicant.  Staff within the NIH awarding component will judge the
acceptability of the revised plan.

The second level of review will be by the National Advisory Dental Research
Council (NADRC).  Among the factors that the NADRC considers will be the
report of the Special Grants Review Committee on the plans for, and success
in, recruitment and retention of women and individuals from underrepresented
minority groups.

The NIDR will notify the applicant of the NADRCþs action shortly after its
meeting.

Schedule

Letter of Intent Receipt Date:  October 1, 1998
Application Receipt Date:       October 22, 1998
Initial Review Group Meeting:   February 1999
Council Meeting:                May 1999
Earliest Award Date:            July 1999

AWARD CRITERIA

Funding decisions will be based on the recommendations of the Special Grant
Review Committee and NADRC, the need for research personnel in particular
program areas, including the need to train clinical investigators, and the
availability of funds. The earliest award date is July 1999.

The NIDR appreciates the value of complementary funding from other public and
private sources, including foundations and industrial concerns, for activities
that will complement and expand those supported by the NIDR.

INQUIRIES

Written and telephone inquiries concerning this RFA are encouraged. The
opportunity to clarify any issues or questions from potential applicants is
welcome.

Direct inquiries regarding programmatic issues to:

James A. Lipton, DDS, Ph.D.
Division of Extramural Research
National Institute of Dental Research
Natcher Building, Room 4AN-18J
Bethesda, MD  20892-6402
Telephone:  (301) 594-2618 or 594-7710
FAX:  (301) 480-8318
Email:  liptonj@de45.nidr.nih.gov

Direct inquiries pertaining to fiscal matters to:

Mr. Martin R. Rubinstein
Division of Extramural Research
National Institute of Dental Research
Natcher Building, Room 4AS-55
Bethesda, MD  20892-6402
Telephone:  (301) 594-4800
FAX:  (301) 480-8301
Email:  rubinstein@de45.nidr.nih.gov

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance No.
93.121.  NRSA Institutional Research Training Grants are made under the
authority of Section 487 of the Public Health Service (PHS) Act as amended (42
USC 288).  Title 42 of the Code of Federal Regulations, Part 66, is applicable
to this program.  This program is not subject to the intergovernmental review
requirements of Executive Order 12372 or Health Systems Agency review.

The PHS strongly encourages all grant and contract recipients to provide a
smoke-free workplace and promote the non-use of all tobacco products.  In
addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking
in certain facilities (or in some cases, any portion of a facility) in which
regular or routine education, library, day care, health care or early
childhood development services are provided to children.  This is consistent
with the PHS mission to protect and advance the physical and mental health of
the American people.


Weekly TOC for this Announcement
NIH Funding Opportunities and Notices


Office of Extramural Research (OER) - Home Page Office of Extramural
Research (OER)
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Bethesda, Maryland 20892
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and Human Services (HHS)
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