SMALL GRANT PROGRAM FOR THE NIAMS Release Date: September 16, 1998 RFA: AR-99-001 P.T. National Institute of Arthritis and Musculoskeletal and Skin Diseases Application Receipt Date: January 22, 1999 PURPOSE The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is seeking small grant (R03) applications to stimulate and facilitate the entry of promising new investigators into high priority areas of NIAMS research. Applications are especially encouraged from new investigators who hold a faculty position at an Historically Black College or University (HBCU) or other institutions that have student populations consisting predominantly of individuals from racial or ethnic groups that are underrepresented in science. This one-time solicitation will provide support for pilot research that is likely to lead to a subsequent individual research project grant (R01). HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This Request for Applications (RFA), Small Grant Program for the NIAMS, is related to the priority area of chronic diseases. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-11474-0 or Summary Report: Stock No. 017-001-11473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as Principal Investigators. Foreign organizations and institutions are not eligible. Participation in the program by investigators at minority institutions is strongly encouraged. Pilot project grants awarded through this RFA may not be used to support thesis or dissertation research. Former and current recipients of NIH small research grants (R03), Academic Research Enhancement Awards (AREA) (R15), Mentored Clinical Scientist Development Awards (K08), Mentored Research Scientist Development Awards (K01), Shannon Awards (R55), or Individual (F32) or Institutional (T32) National Research Service Award (NRSA) training support are eligible to apply for this Small Grant Program, dependent upon the status of other support for the project. Any current support by the F32 or T32 mechanisms must terminate before Small Grant support begins. The work proposed may not overlap significantly with the aims of currently supported projects in which the Principal Investigator has participated during the last five years. (Information on such projects is to be provided as part of the Principal Investigator's Biographical Sketch, as described below under Application Procedures.) Current and previous recipients of NIH funding through Research Project Grants (R01), FIRST (R29) awards or any non-mentored career development award mechanism are ineligible for this Small Grants Program. Principal Investigators of research subprojects of Research Program Projects (P01) and Centers (P50 and P60) and individuals who have received research support from the National Science Foundation (NSF) or Department of Veterans Affairs (VA) as Principal Investigators are also ineligible. Individuals whose sole previous support has been through pilot and feasibility studies may apply. Investigators who have questions about eligibility should contact one of the program officials listed under INQUIRIES. MECHANISM OF SUPPORT Applicants may request up to $50,000 (direct costs) per year for up to three years through the small grant (R03) mechanism. It is anticipated that grants would be awarded no later than September 30, 1999. These awards are not renewable. Before completion of the R03, investigators are encouraged to seek continuing support for research through a research project grant (R01). Replacement of the Principal Investigator on this award is not permitted. FUNDS AVAILABLE It is estimated that $1.0 million (total costs) will be available to support approximately 10 to 15 awards under this program. Awards are contingent on the availability of appropriated funds and on the receipt of sufficiently meritorious applications meeting the stated eligibility requirements. RESEARCH OBJECTIVES The Small Grant program is designed to facilitate the entry of promising new investigators into high priority areas identified by the NIAMS. Appropriate research areas may include, but are not limited to, the following: o Vascular manifestations of rheumatic, connective tissue, and skin diseases o Studies of vasculitis and vasculopathies in animal models of rheumatic diseases, with emphasis on identification of pathogenetic mechanisms and molecular targets for therapeutic intervention o Therapeutic potential of angiogenesis inhibitors/modulators in rheumatoid arthritis, psoriasis, immune and non-immune inflammation of the skin (including irritant and allergic contact dermatitis), autoimmune diseases of skin, atopic dermatitis, and wound healing o Mechanisms of self-recognition in autoimmunity and design of therapies to prevent abnormal responses to self by affecting antigen processing o Mechanisms of end organ damage in rheumatic and skin disease and dissection of the genetics of end-organ disease o Primary and secondary analysis of data sets from arthritis and musculoskeletal and skin disease studies (clinical trials, epidemiology or applied) o Stem cell biology as related to skin, cartilage, bone, and muscle o Growth and repair of connective tissues, including skin, bone, cartilage, tendon, ligament, muscle, and the intervertebral disc o Interactions between matrices/scaffolds and cells in the use of tissue engineering to repair bone, connective tissues, and skin o Mechanisms of bone, cartilage, muscle, and connective tissue responses to mechanical loading o Molecular mechanisms underlying the responses of muscle to physical activity o Interactions of bone and connective tissue with materials of orthopedic instruments, implants and prostheses, the enhancement of integration with bone, and the development of optimal designs and materials to facilitate this tissue biomaterial interaction o Response of connective tissue to repetitive stresses, including healing/repair, a better understanding of the relationship at the biological and biomechanical interface, and the development and validation of suitable animal models o Models and markers of gender and genetic factors in musculoskeletal injuries and diseases, including animal models of human disease o Studies of regulation of cell signaling in autoreactive cells in lupus, rheumatoid arthritis and other rheumatic diseases o Mechanisms underlying the relationship between the female gender and increased susceptibility to rheumatic diseases o Rheumatic, muscular, and dermatological manifestations of acquired immunodeficiency syndrome o Pathogenesis of alopecia areata and vitiligo o Pathogenesis, genetics, biochemistry, molecular and cellular biology of keloids o Pathogenesis of genetic muscle diseases. This list is intended to be illustrative and not exclusive or restrictive. The purpose of this RFA is to promote investigator initiated research projects on arthritis and musculoskeletal and skin diseases. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification are provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing research involving human subjects should read the "NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research", which have been published in the Federal Register of March 28, 1994 (FR 59 14508-14513) and in the NIH Guide for Grants and Contracts, Vol. 23, No. 11, March 18, 1994. This information is available on the internet at https://grants.nih.gov/grants/guide/notice-files/not94-105.html. Investigators also may obtain copies of the policy from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that children must be included in all human subjects research conducted or supported by the NIH unless there are scientific or ethical reasons not to include them. The goal of the policy is to increase the participation of children in research to obtain appropriate data. This policy applies to all initial (Type 1) applications submitted for receipt dates after October 1, 1998. All investigators proposing research involving human subjects should read the "NIH Policy and Guidelines on the Inclusion of Children as Participants in Research Involving Human Subjects" which was published in the NIH Guide for Grants and Contracts, March 6, 1998. This information is available on the internet at https://grants.nih.gov/grants/guide/notice-files/not98-024.html. Investigators also may obtain copies of the policies on "Inclusion of Women and Minorities in Research Involving Human Subjects" and "Inclusion of Children as Participants in Research Involving Human Subjects" from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. APPLICATION PROCEDURES Applications are to be submitted on grant application form PHS 398 (rev. 5/95). Application kits are available at most institutional offices of sponsored research and may be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/710-0267, Email: grantsinfo@nih.gov. The following instructions are to be used in conjunction with the information accompanying application form PHS 398 (rev. 5/95). They refer only to selected items in the application form. All PHS 398 requirements must be adhered to, with the exception of those items affected by the following instructions; for example, the Research Plan is limited to 10 pages. Applications not conforming to the requested format will be returned to the applicant without review. Please note that some of the information to be omitted from the application at submission may be requested following review if the possibility of funding exists. Face Page o Item 2, Response to Specific Program Announcement: Check the box marked YES. Enter the RFA number (AR-99-001) and title (NIAMS Small Grants Program). o Item 6, Dates of Proposed Period of Support. Up to a total of three years of support may be proposed. o The RFA label available in the PHS 398 application form must be affixed to the bottom of the face page of the application. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. Detailed Budget for Initial Budget Period (Page 4) o Do not complete or submit this page. Budget for Entire Proposed Period of Support (Page 5) o Composite Budget Table: Enter total direct costs requested, up to a maximum of $50,000, for each year of support (up to three). o Justification: Provide a narrative justification for each proposed personnel position, including role on the project and proposed level of effort o Provide narrative justification for the additional resources requested for the conduct of the project. Biographical Sketch (Page 6) (Complete for each of the key personnel listed on Form Page 2.) o Research and Professional Experience: List current position(s) and those previous positions directly relevant to the application. o List selected peer-reviewed publications directly relevant to the proposed project, with full citations. o Provide information on research projects completed and/or research grants in which the investigator participated during the last five years which are relevant to the proposed project. For each project or grant listed, provide title, name of Principal Investigator, funding source, and role on project (if not Principal Investigator). Other Support (Page 7) o Do not complete or submit this section. Research Plan o Items a - d of the Research Plan (Specific Aims, Background and Significance, Preliminary Studies, and Research Design and Methods) may not exceed a total of 10 pages. Please note that a Progress Report is not needed; no competing continuation applications will be accepted for an R03. Appendix o Appendix material may not be used to circumvent the page limitations. Publications may not be submitted as appendix. Checklist o The Checklist should not be submitted. Submit a signed original of the application and four signed copies in one package to: CENTER FOR SCIENTIFIC REVIEW NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC-7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) At the time of submission, one additional copy of the application must be sent to: Tommy L. Broadwater, Ph.D. Scientific Review Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases 45 Center Drive, Room 5AS-25U - MSC 6500 Bethesda, MD 20892-6500 In order not to delay review, it is important that applicants comply with this request. Applications must be received by January 22, 1999. If an application is received after that date, it will be returned to the applicant without review. Only one Small Grant application may be submitted by a Principal Investigator. Applicants may not submit an R01 or any career award (K mechanism) application for the October 1, 1998 or February 1, 1999 receipt date if that application involves significant scientific overlap with a Small Grant application. REVIEW CONSIDERATIONS Upon receipt, applications will be reviewed for completeness by the Center for Scientific Review (CSR). NIAMS staff will review applications for responsiveness to the research objectives of this RFA and for the eligibility of the Principal Investigator under the requirements stated above. Incomplete and/or non- responsive applications will be returned to the applicant without further consideration. Applications that are complete and responsive to the RFA will be evaluated for scientific and technical merit by an appropriate peer review committee convened by the NIAMS in accordance with the usual NIH peer review procedures. As part of the initial merit review, all applications will receive a written critique and undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of applications under review, will be discussed, assigned a priority score, and receive a second level review by the National Arthritis and Musculoskeletal and Skin Disease Advisory Council. Review Criteria The goals of NIH-supported research are to advance our understanding of biological systems, improve the control of disease, and enhance health. In the written comments, reviewers will be asked to discuss the following aspects of the application in order to judge the likelihood that the proposed research will have a substantial impact on the pursuit of these goals. Each of these criteria will be addressed and considered in assigning the overall score, weighting them as appropriate for each application. Note that the application does not need to be strong in all categories to be judged likely to have major scientific impact and thus deserve a high priority score. For example, an investigator may propose to carry out important work that by its nature is not innovative but is essential to move a field forward. (1) Significance. Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge be advanced? What will be the effect of these studies on the concepts or methods that drive this field? (2) Approach. Are the conceptual framework, design, methods, and analyses adequately developed, well-integrated, and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternative tactics? (3) Innovation. Does the project employ novel concepts, approaches or method? Are the aims original and innovative? Does the project challenge existing paradigms or develop new methodologies or technologies? (4) Investigator. Is the investigator appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the principal investigator and other researchers (if any)? (5) Environment. Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed experiments take advantage of unique features of the scientific environment or employ useful collaborative arrangements? Is there evidence of institutional support? In addition, the adequacy of plans to include both genders, minorities and their subgroups, and children as appropriate for the scientific goals of the research will be reviewed. Plans for the recruitment and retention of subjects will also be evaluated. The initial review group will also examine the provisions for the protection of human and animal subjects, the safety of the research environment, and conformance with the NIH Guidelines for the Inclusion of Women and Minorities as Subjects in Clinical Research. AWARD CRITERIA The following will be considered in making funding decisions: o Quality of the proposed project as determined by peer review o Importance of the area to NIAMS research o Availability of funds. INQUIRIES Inquiries are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to one of the following persons, according to scientific area: Dr. Susana A. Serrate-Sztein Rheumatic Diseases 45 Center Drive, Room 5AS-37G Bethesda, MD 20892-6500 Telephone: (301) 594-5032 FAX: (301) 480-4543 Email: SzteinS@ep.niams.nih.gov Dr. Bernadette Tyree Cartilage and Connective Tissue 45 Center Drive, Room 5AS-37J Bethesda, MD 20892-6500 Telephone: (301) 594-5032 FAX: (301) 594-4543 Email: TyreeB@ep.niams.nih.gov Dr. Richard W. Lymn Muscle Biology 45 Center Drive, Room 5AS-49E Bethesda, MD 20892-6500 Telephone: (301) 594-5128 FAX: (301) 480-4543 Email: LymnR@ep.niams.nih.gov Dr. James S. Panagis Orthopedics 45 Center Drive, Room 5AS-37K Bethesda, MD 20892-6500 Telephone: (301) 594-5055 FAX: (301) 594-4543 Email: PanagisJ@ep.niams.nih.gov Dr. Alan N. Moshell Skin Diseases 45 Center Drive, Room 5AS-25L Bethesda, MD 20892-6500 Telephone: (301) 594-5017 FAX: (301) 480-4543 Email: MoshellA@ep.niams.nih.gov Dr. William J. Sharrock Bone Biology 45 Center Drive, Room 5AS-37A Bethesda, MD 20892-6500 Telephone: (301) 594-5055 FAX: (301) 480-4543 Email: SharrocW@ep.niams.nih.gov Dr. Joan McGowan Bone Diseases 45 Center Drive, Room 5AS-43E Bethesda, MD 20892-6500 Telephone: (301) 594-5055 FAX: (301) 480-4543 Email: McgowanJ@ep.niams.nih.gov Direct inquiries regarding fiscal matters to: Sally A Nichols Grants Management Office National Institute of Arthritis and Musculoskeletal and Skin Diseases 45 Center Drive, Room 5AS-49F, MSC 6500 Bethesda, MD 20892-6500 Telephone: (301) 594-3535 FAX: (301) 480-5450 Email: NicholsS@ep.niams.nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.846. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410), as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant and contract recipients to provide a smoke- free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
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