Full Text AA-97-006 COLLABORATIVE MINORITY ALCOHOL RESEARCH DEVELOPMENT PROGRAM NIH GUIDE, Volume 26, Number 14, May 2, 1997 RFA: AA-97-006 P.T. 34, FF Keywords: Alcohol/Alcoholism National Institute on Alcohol Abuse and Alcoholism Letter of Intent Receipt Date: June 16, 1997 Application Receipt Date: July 15, 1997 PURPOSE The National Institute on Alcohol Abuse and Alcoholism (NIAAA) in collaboration with the Office for Research on Minority Health (ORMH) of the National Institutes of Health (NIH) invites applications for Collaborative Minority Institution Alcohol Research Development grants (CMIARD). The long range goal of the Collaborative Minority Institution Alcohol Research Development Program is to strengthen the alcohol research capacity of predominantly minority institutions by fostering collaborations with research intensive institutions, and through this means, expand the capabilities of the research scientists in these institutions to research on alcohol-related health issues within minority communities. For the purpose of this solicitation, African Americans, Hispanics, Native Americans, and Alaskan Natives are considered to be racial or ethnic minorities. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This Request for Applications (RFA), Collaborative Minority Alcohol Research Development Program, is related to the priority area of alcohol abuse and alcoholism reduction. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington DC 20402-9325 (Telephone 202-512-1800). ELIGIBILITY REQUIREMENTS Only predominantly minority institutions as defined below are eligible to submit applications in response to this request. Applications from foreign institutions are not eligible. Applications may contain a foreign collaborative research project if the project is specifically relevant to an alcohol-related U.S. minority health issue. To be responsive to this RFA, eligible institutions must have documented collaborative agreements with established alcohol research investigators at an institution other than the applicant institution. It is anticipated that in most instances, the collaborating scientists will be located at one or more research intensive institutions. Definitions 1. A "predominantly minority institution" is an academic, health care or research institution with an enrollment and/or faculty predominantly of ethnic minorities. For most academic institutions this would be a school whose student enrollment and/or faculty is composed of 50 percent or more ethnic minorities. "Hispanic Serving Institutions" are defined as having 25 percent Hispanic students and are eligible to apply. 2. An "established research investigator" is an individual who in Fiscal Year 1997 is the recipient of independent research support from any awarding component of the NIH through the one or more of the following mechanisms: R01, R29, R37, or a component director within a P30 or P50 Center. 3. An "established alcohol research investigator" is an individual who is currently the recipient of independent research support from the NIAAA through one or more of the following mechanisms: R01, R29, R37, or a component director within a P50 Center. 4. A "research intensive institution" is a university or research institution which received at least $20 million in NIH research and research training support in Fiscal Year 1996. MECHANISM OF SUPPORT This RFA is a one-time solicitation by the NIAAA. The administrative and funding instrument to be used for this program will be a Resource Related Research Project Cooperative Agreement (U24), an "assistance" mechanism (rather than an "acquisition" mechanism), in which substantial NIH scientific and/or programmatic involvement with the awardee is anticipated during performance of the activity. Under the cooperative agreement, the NIH purpose is to support and/or stimulate the recipient's activity by involvement in and otherwise working jointly with the award recipient in a partner role, but it is not to assume direction, prime responsibility, or a dominant role in the activity. Details of the responsibilities, relationships, and governance of the study to be funded under the cooperative agreement(s) are discussed later in this document under the section "Terms and Conditions of Award." FUNDS AVAILABLE It is anticipated that up to three five-year awards will be made in response to this RFA in Fiscal Year 1997. The specific number of awards will be contingent upon the scientific and technical merit of the applications. The cost may not exceed $400,000 in direct costs for the initial year. Although the financial plans of the NIAAA provide for the support of this program, awards pursuant to this RFA are contingent upon availability of funds. RESEARCH OBJECTIVES Epidemiological studies indicate major differences in alcohol morbidity and mortality among different racial and ethnic groups. In the United States, alcohol use is involved in nearly 100,000 deaths annually from traffic crashes, cirrhosis of the liver, self-directed and other-directed violence, falls, burns, drowning, and other unintentional injuries. Alcohol misuse results in violence, family discord, job loss, and serious medical problems, including alcohol-related birth defects. The costs and problems are unevenly distributed across racial and ethnic groups, with disproportionately higher problems observed in some sub-populations of African Americans, Hispanic Americans, and Native Americans. Research has produced both important findings and new questions. A study of alcohol-related mortality in California showed that African Americans and Hispanics had higher rates of mortality from alcoholic cirrhosis than did whites or Asian Americans. Further, death rates attributed to alcohol dependence syndrome also were highest for African Americans, although a higher percentage of African Americans than whites abstain from using alcohol. The higher rates of medical problems seen in African Americans thus occur among a smaller percentage of the African American population when compared with whites. Epidemiological evidence indicates that the incidence of fetal alcohol syndrome (FAS) and other alcohol-related birth defects is greater among both Native American and African American populations than other U.S. populations. The reasons for these observed differential prevalence rates have not been explained. Over the last several years the NIAAA has increasingly focused attention upon enhancing its commitment to research on topics germane to the health and well-being of minority Americans, and involving researchers in minority institutions in alcohol research and training. Recognizing the importance of minority institution involvement in research on minority health issues, the objective of this cooperative agreement is to foster the capability of minority institutions to submit applications for research support that are competitive within the NIH peer review process. As well, the ability to obtain such support, especially from the Federal Government, is, in turn, often dependent on a successful record of previous research and on a research infrastructure capable of supporting proposed research projects as well as on the inherent scientific merit of the projects. Without the opportunity to establish such a research record or to develop the necessary resources to support research, qualified scientists at minority institutions are often disadvantaged when compared with their colleagues at research-intensive institutions. Thus, a central aim of the CMIARD program is to enhance the funding opportunities for scientists at minority institutions by pairing them, through collaborative affiliations, with scientists, typically from research-intensive institutions, who have both the resources and experience necessary to successfully compete in the NIH scientific peer review system. It is anticipated that accomplishment of this aim will not only enhance the research careers of minority scientists but also attract qualified minority undergraduate and graduate students to careers in alcohol research. Scientific and Research Opportunities The following topics are suggested for inclusion in CMIARD applications. These, however, are not listed in priority order nor are they exhaustive, and other research topics relevant to alcohol research may be proposed. o Studies of the incidence and prevalence of alcohol abuse and alcoholism in minority populations and subpopulations o Studies of the relationship of the general health status of minorities to the prevalence of alcohol related disorders. o Studies designed to investigate factors contributing to the excess morbidity and mortality associated with alcohol abuse and alcoholism in minority populations. o Biological and behavioral studies on the interrelationship of alcohol use and abuse to AIDS/HIV in minority populations. o Studies of the underlying genetic and environmental factors involved in alcohol abuse and alcoholism. o Studies of fetal alcohol syndrome, alcohol-related birth defects and alcohol-related neurobehavioral disorder. o Studies of factors contributing to differences in the rates of alcohol dependence in minorities and non-minorities. o Studies to investigate the pathogenesis and treatment of alcoholism. o Studies of use and barriers to use of alcohol-related health services. APPLICATION CHARACTERISTICS The CMIARD award is expected to support a minimum of three alcohol research projects. The projects may be of a pilot or exploratory nature. Each project will involve participation by co-investigators from the applicant minority institution and at least one external scientist, preferentially from a research-intensive institution(s)(see Definitions). Each project should have at least one collaborative scientist who meets the qualifications of an "established research investigator" (see Definitions, above). The complete CMIARD application should have at least two collaborating scientists who meet the qualifications of "established alcohol research investigator" (see Definitions, above). Projects involving outreach to minority populations are encouraged, and at least one project must focus on a topic of significance to an alcohol related minority health issue. Each CMIARD will have its own unique Project Advisory Committee (PAC); membership requirements for this Committee are described below. The role of the PAC is provide advice to the Principal Investigator on scientific and related issues pertinent to the operation of the CMIARD. Among its duties, the PAC will assess interim progress of all projects within the CMIARD, and review projects proposed for future implementation. Core resources such as development activities, administrative services, unique clinical facilities, animal facilities, biostatistical and computer services, and shared equipment may be supported. The level of support for core resources should be commensurate with the level of research proposed and funded. The administrative core might include support of meetings or other activities to explore new and expanded collaborative research and research training. Travel to the site of an annual CMIARD Directors' meeting should be budgeted in the administrative core. Budgetary constraints, however, preclude expenditures for expensive items of equipment or renovations. While formal research training activities cannot be supported directly by this grant mechanism, there is realization that participation in research supported by the CMIARD program can have a significant impact on the career development of minority faculty members. In addition, the more traditional mechanisms of support for career development (i.e., K01, K08) remain available. The application should address each of the following elements: I. Administrative Core The CMIARD must have strong and experienced central leadership to coordinate proposed activities and to keep all components informed of important activities. Critical elements of the Administrative Core follow: The Principal Investigator should be a senior experienced investigator from the minority institution who will have substantial involvement in the operation of the CMIARD program. The Administrative Core must establish a Project Advisory Committee (PAC) of four to six members. At least one PAC member should be from a relevant community group and two members should be experienced alcohol researchers. The NIAAA staff collaborator will be an additional voting member of the PAC. The PAC will meet at least twice yearly to review activities and make recommendations on CMIARD functions. The Administrative Core will have the responsibility of preparing a yearly progress report for the project, and attending an annual meeting of CMIARD Directors. II. Information Transfer Each CMIARD should create a program for disseminating alcohol research information. The audiences for these activities should include health care students and professionals, community based organizations and researchers at the host institution as well as investigators at other institutions. Information transfer activities may include, but are not limited to, activities such as training programs, short courses, telemedicine, presentations at professional meetings and publications. The content of these activities must be developed in collaboration with the NIAAA and established alcohol research scientists. The CMIARD may wish to seek Continuing Health Education credit for participants. The information transfer and faculty development function should work closely with the Administrative Core. III. Five-Year Research Plan Each CMIARD shall develop a 5-year research plan based on areas of alcohol research interests. The selection of proposed projects must reflect the goals of the research plan and must be relevant to the research program and priorities of the NIAAA. The plan should state how the institution will build on its strengths and capabilities to conduct alcohol research and address the needs of the institution in furthering its goals. IV. Development of Summary Report The Administrative Core will prepare a yearly progress report and a document near the conclusion of the first 5 years of CMIARD experience. The document will contain, but not be limited to, the CMIARD description; findings regarding the collaborative approach to project development and the enhancement of faculty expertise. Research findings and observations on the administration of the program should be included. TERMS AND CONDITIONS OF AWARD The following terms and conditions will be incorporated into the award statement and provided to the Principal Investigator(s) as well as the institutional official at the time of award. These special Terms of Award are in addition to and not in lieu of otherwise applicable OMB administrative guidelines, HHS Grant Administration Regulations at 45 CFR Parts 74 and 92, and other HHS, PHS, and NIH Grant Administration policy statements. The administrative and funding instrument used for this program is a resource related research project cooperative agreement (U24), an "assistance" mechanism (rather than an "acquisition" mechanism) in which substantial NIH scientific and/or programmatic involvement with the awardee is anticipated during performance of the activity. Under the cooperative agreement, the NIH purpose is to support and/or stimulate the recipient's activity by involvement in and otherwise working jointly with the award recipient in a partner role, but it is not to assume direction, prime responsibility, or a dominant role in the activity. Consistent with this concept, the dominant role and prime responsibility for the project as a whole resides with the awardee(s), although specific tasks and activities in carrying out the studies will be shared among the awardees and the NIAAA project staff. Details of the roles of the parties are described later in this section. A. Awardee Rights and Responsibilities Awardees will have primary and lead responsibilities for the project including, as appropriate, protocol development; subject recruitment; data collection, analysis and quality control; safety monitoring; and preparation of publications. The Principal Investigator defines the details for the project; retains primary responsibility for the performance of the activity; and agrees to close coordination, cooperation, and assistance of NIAAA extramural staff in aspects of scientific and technical management of the project as described herein. 1. Project Advisory Committee Membership and Meeting Attendance Each CMIARD must establish a Project Advisory Committee (PAC), composed of at least four and no more than six members (not including the NIAAA staff collaborator). An NIAAA staff collaborator will serve as a member of each PAC, and exercise one vote on that committee. The PAC should not include any of the external researchers involved in any of the projects. The Chairperson of the PAC will be selected by vote of the PAC members; the NIAAA staff collaborator may not serve as Chairperson. Each member will have one vote, should a vote of the PAC be necessary to make a decision. Each PAC will meet at least twice a year. 2. Role of Awardee Institution Each awardee institution and its corresponding investigators will be responsible for developing and implementing its research programs taking into consideration the recommendations of the PAC. 3. Role of Project Advisory Committee The Project Advisory Committee (PAC) will be the major advisory body to the Principal Investigator (PI) for all scientific decisions pertaining to project selection and conduct within the approved scope of the award. The PAC will facilitate collaborative interactions between the minority institution scientists and external collaborating scientists; monitor progress of existing projects within the individual CMIARD award; and, review and make recommendations for new pilot and exploratory projects within the program. B. NIAAA Staff Responsibilities The NIAAA staff role in a cooperative agreement will extend beyond the level normally required for stewardship of a grant because of the developmental nature of the research program, the potential need for technical assistance, and for monitoring and possible reassessment of project objectives. The NIAAA extramural program official and staff collaborator perform different functions in research projects supported under the cooperative agreement mechanism. 1. Program Official The Program Official provides normal stewardship of the award and has overall responsibility for monitoring the conduct, progress, and fiscal management of the program. Progress of the project will be reviewed by the Program Official annually at the time of each continuation application to assure that satisfactory progress is being made in achieving the objectives of the project. 2. NIAAA Staff Collaborator The NIAAA Staff Collaborator has substantial scientific input in collaboration with award recipients, in both planning and conduct of the research. The NIAAA Staff Collaborator will a) facilitate the coordination necessary to manage this complex project; b) participate in all PAC duties and responsibilities; c) participate in monitoring progress of ongoing studies; d) participate in planning and implementing efforts to disseminate information; e) provide instruction in faculty development activities; f) participate in data interpretation and, when appropriate, in the preparation of publications and presentations. The NIAAA staff is subject to the same publication/authorship policies governing all participants in the study, as well as to the official NIH Publication Policy governing extramural employees. 3. Arbitration Any disagreement that may arise on scientific/programmatic matters (within the scope of the award), between award recipients and the NIAAA may be brought to arbitration. An arbitration panel will be composed of three members; one selected by the Principal Investigator of the CMIARD, a second member selected by the NIAAA, and the third member selected by the two prior selected members. This special arbitration procedure in no way affects the awardee's right to appeal an adverse action that is otherwise appealable in accordance with the PHS regulations at 42 CFR Part 50, Subpart D and HHS regulation at 45 CFR Part 16. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification is provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing research involving human subjects should read the "NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical Research," which have been published in the Federal Register of March 28, 1994 (FR 59 14508-14513) and in the NIH Guide for Grants and Contracts, Vol. 23, No. 11, March 18, 1994. LETTER OF INTENT Prospective applicants are asked to submit, by June 16, 1997, a letter of intent that includes a descriptive title of the proposed research, name, address, and telephone number of the Principal Investigator, identities of other key personnel and participating institutions, and number and title of the RFA in response to which the application may be submitted. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information allows the NIAAA staff to estimate the potential review workload and to avoid conflict of interest in the review. The letter of intent is to be sent to: RFA-AA-97-006 Office of Scientific Affairs National Institute on Alcohol Abuse and Alcoholism 6000 Executive Boulevard, Suite 409 - MSC 7003 Bethesda, MD 20892-7003 Telephone: (301) 443-4375 FAX: (301) 443-6077 APPLICATION PROCEDURES The research grant application form PHS 398 (rev. 5/95) is to be used in applying for these grants. Applications kits are available at most institutional offices of sponsored research and may be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, Telephone 301/710-0267, E-mail: ASKNIH@odrockm1.od.nih.gov. Applications must address the requirements as outlined above, research objectives, special requirements and terms, and conditions. SPECIAL REQUIREMENTS 1. A 5-year research plan is required. This plan must describe how the scientific agenda of the CMIARD will be pursued and how the institution plans to develop and expand its alcohol research capabilities. 2. All costs required for the proposed CMIARD application must be included in the application and must be fully justified. Requested budgets should include travel to the Washington, D.C., for three individuals to attend one annual CMIARD Director's meeting. 3. The CMIARD application should be organized into discrete components that comprise a cohesive application. Each component is either a research component or a core component for which a detailed budget is included in the application. The application must include an administrative core and at least three pilot or exploratory projects. Shared scientific resource core (s), if any, should be included within the administrative core. 4. The administrative core component is limited to 15 pages. Each pilot or exploratory project should be described in no more than seven pages . The description of each pilot or exploratory project should contain a statement of the problem, the methods to be used, the anticipated results, and subsequent planned efforts leading to an independent investigator award. Pilot or exploratory studies are limited to 2 years. 5. Biographical Sketches for both the minority institution investigators and external collaborators should be included in the application. Signed letter(s) of agreement between the collaborating investigators and the minority institution should be included in the application. 6. The CMIARD application must include the description of a process by which its PAC and PI will select future pilot and exploratory studies, including criteria to be used in this decision process. 7. Facilities and Environment--Applicants must demonstrate the availability of adequate laboratory, clinical, and office facilities to carry out the objectives of the CMIARD. 8. Organization and Administration--The CMIARD application must have an identifiable organizational structure with clear lines of authority which will facilitate coordination among CMIARD participants. The applicant organization must designate an appropriate institutional official to serve as principal investigator for the CMIARD. This individual must demonstrate the ability to organize, administer, and direct the CMIARD projects. The principal investigator will have direct authority over the administrative core. The administrative core should be described in sufficient detail to assure that all proposed activities will function optimally. 9. Budget Considerations----All CMIARD applicants should request and provide justification for 5 years of support. The total costs for the first year of support may not exceed $400,000 in direct costs. Future year costs requests should be in accord with NIH cost containment principles. The distribution of funds within the CMIARD to each participating project is at the discretion of the applicant institution and must be justified by the activities of each project component. Support for secretarial and administrative staff may be provided to the extent that their activities relate to meeting specified CMIARD objectives. Similarly, travel by project personnel must be justified as meeting project objectives. Travel and per diem for three persons to attend an annual day and a half meeting CMIARD Director's meeting in the Washington, D.C., area and for travel of four investigators to attend appropriate annual meetings of the alcohol research professional societies should be included in the budget. Consultants' costs and costs for the participation of collaborators are anticipated and these should be described and included as required by the CMIARD's objectives. 10. The RFA label available in the PHS 398 (rev. 5/95) application form must be affixed to the bottom of the face page of the application. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition, the RFA title and number must be typed on line 2a of the face page of the application form and the YES box must be marked. 11. Submit a signed, typewritten original of the application, including the checklist and three signed photocopies in one package to: Division of Research Grants National Institutes of Health 6701 Rockledge Drive, Room 1040-MSC 7710 Bethesda, MD 20892-7710 Bethesda, MD 20817-7710 (for express/courier service) At the time of submission, two additional copies of the application must also be sent to: RFA-AA-97-006 Office of Scientific Affairs National Institute on Alcohol Abuse and Alcoholism Willco Building, Room 409 6000 Executive Boulevard MSC 7003 Bethesda, Maryland 20892-7003 Rockville, Maryland 20852-7003 (for express/courier service) Applications must be received by July 15, 1997. If an application is received after that date, it will be returned to the applicant without review. The Division of Research Grants (DRG) will not accept any application in response to this RFA that is essentially the same as one currently pending initial review, unless the applicant withdraws the pending application. The DRG will not accept any application that is essentially the same as one already reviewed. This does not preclude the submission of a substantial revision of an application already reviewed, but such an application must follow the guidance in the PHS Form 398 application instructions for the preparation of revised applications, including an introduction addressing the previous critique. REVIEW METHOD Upon receipt, applications will be reviewed for completeness by the DRG and responsiveness by the NIAAA. Incomplete or unresponsive applications will be returned to the applicant without further consideration. Applications that are complete and responsive to the RFA will be evaluated for scientific and technical merit by an appropriate peer review group convened by the Institute in accordance with the review criteria stated below. As part of the initial merit review, a streamlined review process may be used by the initial review group in which applications may or may not be discussed based on their scientific merit relative to other applications received in response to the RFA. Applications which are fully discussed will be assigned a priority score. Applications which are not discussed will be withdrawn from further considerations and the Principal Investigator and the official signing for the applicant organization will be notified. The second level of review will be provided by the National Advisory Council on Alcohol Abuse and Alcoholism. Review Criteria Each application must be thorough and complete enough to stand on its own. Additional materials or revisions will not be accepted after the receipt date. It is strongly recommended that Institutional Review Board (IRB) approval be secured prior to submission. Major factors to be considered in the overall evaluation of the applications include: I. The following criteria will be used in judging the adequacy of plans for the administrative core: o Evidence of the overall 5-year plan of research reflecting the goals of the CMIARD. o Evidence of experience in coordinating multi-disciplinary projects and administrative core activities. o Evidence of experience with, and a commitment to, fostering working relationships with minority populations. o The degree to which the proposed collaboration presents opportunities for furthering research programs in the minority institution. o Evidence of the ability to disseminate information through professional and less formal mechanisms. o Appropriateness of the proposed budget. o Evidence of the establishment of collaborations between faculty from the minority institution and external scientists from research intensive institutions. o Evidence that the proposed PAC has appropriate scientific experience, including alcohol research, and minority community membership, and that the individuals are committed to the success of the program. o The promise and potential of the pilot and exploratory studies proposed; and the potential of the proposed research as a building block in the development of future research. o The adequacy of the qualifications and relevant experience of the principal investigator, key personnel and the ability of the collaborator to undertake the research activities proposed in the project. o Evidence that the mechanisms for review and administration of the pilot studies will function to produce studies that meet substantive objectives and have a reasonable expectation of subsequent independent funding. II. The following criteria will be used to evaluate the commitment of the applicant institution to program objectives: o Evidence that the academic environment(s) and its/their resources committed to the application including space, equipment, and facilities are adequate to meet the proposed objectives. o Evidence that the host institution is sufficiently flexible to foster multi-disciplinary interaction with investigators internal and external to the university. III. The following criteria will be used to evaluate the potential for productive collaborative studies and the potential of the proposed projects: Review of developmental research projects is based not only on the traditional considerations necessary for peer evaluation of scientific merit, but also takes into account the preliminary nature of the proposed studies and, in a broader sense, the extent to which the research activity will contribute to the goals of the CMIARD. The criteria for review of these developmental research projects include: o Evidence of a minimum of three well-developed projects. o The availability of adequate facilities, general environment for the conduct of the proposed studies and other resources and collaborative arrangements. o If studies involving human subjects are proposed, evidence of an ability to recruit and retain subjects for study will also be evaluated. o The scientific, health or medical significance of the proposed project. o Adequacy of procedures for the protection of human and animal subjects and for the environment. o Adequacy of plans for addressing compliance with NIH policies on inclusion of women and minorities in studies involving human subjects. AWARD CRITERIA Award decisions will be based on the technical merit of the application as determined by peer review, availability of funds, and other programmatic priorities to ensure a balance among the various types of programs, populations served, and/or geographic distribution. INQUIRIES Written and telephone inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcomed. Direct inquiries regarding programmatic issues to: Ernestine Vanderveen, Ph.D. Division of Basic Research National Institute on Alcohol Abuse and Alcoholism 6000 Executive Boulevard - MSC 7003 Bethesda, MD 20892-7003 Rockville, MD 20852-7003 (for express/courier service) Telephone: (301) 443-1273 FAX: (301) 594-0673 E-mail: tvander@willco.nih.niaaa.gov Direct inquiries regarding fiscal matters to: Linda Hilley Grants Management Branch National Institute on Alcohol Abuse and Alcoholism 6000 Executive Boulevard MSC 7003 Bethesda, MD 20892-7003 Telephone: (301) 443-0915 FAX: (301) 443-3891 E-mail: lhilley@willco.niaaa.nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance, No. 93.273. Awards are made under the authorization of the Public Health Service Act, Sections 301 and 464H, and administered under the PHS policies and Federal Regulations at Title 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency Review. The PHS strongly encourages all grant recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people. .
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