NIDDK CAREER TRANSITION AWARD (K22)

RELEASE DATE:  August 21, 2002
 
PA NUMBER:  PAR-02-151 (This PAR has been reissued, see PAR-06-002)
 
EXPIRATION DATE:  After November 18, 2004
 
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 (http://www.niddk.nih.gov/)
 
APPLICATION RECEIPT DATE:  November 18, 2002, November 18, 2003, November 18, 
2004

THIS PROGRAM ANNOUNCEMENT CONTAINS THE FOLLOWING INFORMATION
 
o Purpose
o Research Objectives
o NIDDK Intramural Research Program
o Mechanism of Support
o Eligible Institutions
o Applicant Eligibility Criteria
o Special Requirements and Restrictions
o Inquiries for Information
o Submitting an Application
o Supplemental Guidelines
o Review Considerations
o Selection and Award Procedures
o Required Federal Citations
 
PURPOSE
 
The overall goals of the National Institute of Diabetes and Digestive and 
Kidney Diseases (NIDDK) Career Transition Award (K22) are to enable 
outstanding individuals to obtain a research training experience in the NIDDK 
Intramural Research Program and to facilitate their successful transition to 
an extramural environment as independent researchers. The award will provide 
three years of support for research training in an NIDDK intramural 
laboratory followed by two years of support for an independent research 
program at an extramural institution.  The combined duration cannot exceed 
five years.  It is anticipated that awardees will subsequently obtain 
research project grants such as the R01 to support the continuation of their 
work.

RESEARCH OBJECTIVES
 
The NIDDK intramural research environment provides a rich and unique 
opportunity for the training of postdoctoral fellows and early career 
scientists.  The goal of the NIDDK K22 program is to provide highly qualified 
young investigators with an opportunity to receive research training 
experience in the NIDDK Intramural Research Program and then to provide them 
with bridge funding to facilitate the transition of their research programs 
to extramural institutions.  To achieve these objectives, the NIDDK Career 
Transition Award will provide a maximum total of five years of research 
support divided into two phases: Phase I is for research training at an 
intramural facility of NIDDK and Phase II is for research at a domestic, non-
federal organization.
 
NIDDK Intramural Research Program
 
The Intramural Research Program at NIDDK conducts basic biomedical, 
translational, and clinical research in the broad areas of diabetes, 
endocrinology, metabolism, transplantation, hepatitis, digestive and kidney 
diseases, hematopoiesis and hemoglobinopathies.  All of the major scientific 
disciplines are represented, including (in alphabetical order): biochemistry, 
bioinformatics, biophysics, biostatistics, cell biology, chemical physics, 
developmental biology, epidemiology, genetics, mathematical/computational 
biology, medicinal chemistry, molecular biology, pharmacology, physiology, 
and structural biology.   

Intramural investigators pursue a broad array of projects in biomedical 
research ranging from fundamental analyses of protein structure and function, 
through protein chemistry, cell biology, signal transduction, gene 
regulation, tissue development and differentiation to more applied and 
population-based clinical research on the genetics, etiology, pathogenesis 
and treatment of a variety of endocrine and renal disorders.  Detailed 
information about potential intramural NIDDK mentors and laboratories may be 
obtained at http://www.niddk.nih.gov/intram/intram.htm or through a keyword 
search at http://intramural.nih.gov/search (choose option 3 and select NIDDK 
from the pull-down menu). 
 
MECHANISM OF SUPPORT
 
This Program Announcement will use the National Institutes of Health (NIH) 
K22 award mechanism.  Responsibility for the planning, direction, and 
execution of the proposed project will reside with the proposed mentor as 
well as with the applicant.  The total period of support is a maximum of five 
years (three years of intramural funding and two years of extramural 
funding).  Awards are not renewable.  Total direct costs for Phase I 
(intramural) are based on the candidate"s experience, those for Phase II 
(extramural) cannot exceed $175,000 per year (for salary and research 
support) plus fringe benefits (specific allowable costs are described below).

Transition from Phase I (the intramural period of support) to Phase II (the 
extramural period) is not automatic.  Approval of the transition will be 
based on the success of the awardee"s research program as determined by 
yearly scientific review and by the evaluation of a research and career 
development plan to be carried out at the extramural institution.  
Additionally, the extramural institution must demonstrate a commitment to the 
candidate by providing protected research time, space needed to perform the 
proposed research, and a plan for career development.  Awardees approved to 
proceed with the second phase of support will receive notification of 
approval in writing from NIDDK.  An application from the extramural 
institution on behalf of the candidate will be required for NIDDK to process 
the second phase of the award (Details appear in the section "Activating the 
Extramural Support Phase" in this announcement).
 
Applicants should also be aware that they are eligible to apply for up to 
five years of support via the Mentored Research Scientist Development Award 
(K01), the Mentored Clinical Scientist Development Award (K08), or the 
Mentored Patient-oriented Research Career Development Award (K23) in place of 
the two years of the K22 Phase II.  Consultation with NIDDK program staff is 
encouraged.
 
ELIGIBLE INSTITUTIONS 
 
Phase I
o Phase I applications may only be submitted for research within the 
NIDDK intramural program at the National Institutes of Health 
(Bethesda, MD or Phoenix, AZ sites). 
 
Phase II
Applications for transition to Phase II require that the extramural domestic 
institution falls within one or more of the following categories: 
o For-profit or non-profit organizations
o Public or private institutions, such as universities, colleges, and 
hospitals
o Units of state and local governments
o Eligible agencies of the Federal government
	
APPLICANT ELIGIBILITY CRITERIA
 
Applicants must have a research or a health-professional doctorate or its 
equivalent, and must have some research experience, during which the 
potential for highly productive basic or clinical research has been 
demonstrated.  In general, individuals who have had more than five years of 
postdoctoral research training at the time of application are not eligible to 
apply, however, clinical training does not count against the five-year rule.  
The required research experience may have been completed in an intramural NIH 
laboratory or at an extramural institution.  During the intramural phase of 
the award, the candidate will spend full time on research.  To obtain support 
for the extramural phase, candidates must be in a formal tenure-track (or 
equivalent) position in an extramural institution.  During the extramural 
phase, the candidate must spend a minimum of 75 percent of full-time 
professional effort conducting research and research career development 
activities.  Individuals from groups underrepresented in the sciences as well 
as individuals with disabilities are especially encouraged to apply.
 
At the time of award, candidates must be U.S. citizens or non-citizen 
nationals, or must have been lawfully admitted for permanent residence and 
possess an Alien Registration Receipt Card (I-551) or some other verification 
of legal admission as a permanent resident.  Non-citizen nationals are 
generally persons born in outlying possessions of the U.S. (i.e., American 
Samoa and Swains Island).  Individuals on temporary or student visas are not 
eligible.
 
Former principal investigators on NIH research projects (R01), FIRST Awards 
(R29), SBIR/STTR awards, sub-projects of program projects (P01) or center 
grants (P50), K08 awards, or the equivalent, are not eligible.  Former 
principal investigators of an NIH Small Grant (R03) or 
Exploratory/Development Grants (R21) remain eligible.  
 
SPECIAL REQUIREMENTS
 
Acceptance into the NIDDK Career Transition Award Program does not convey any 
commitment or intent of NIDDK to consider the awardee for a tenure-track 
position within NIDDK.  The NIDDK Career Transition Award is specifically 
intended to help develop scientists who will pursue their careers in the 
extramural biomedical research community.  However, NIDDK K22 awardees are 
not explicitly precluded from applying for available tenure- track positions 
at the NIH.  If an awardee obtains an NIH staff or tenure-track position, the 
NIDDK Career Transition Award will be terminated.
 
Once a K22 award is made, the awardee is expected to remain within the NIDDK 
Intramural Program for three years.  The award of Phase I, the intramural 
segment, does not necessarily guarantee the transition to Phase II, the 
extramural segment.  All awardees will be evaluated on a yearly basis.  The 
second annual scientific review will also constitute the formal review to 
determine suitability for transition to the extramural phase of the award.
 
Allowable costs are restricted as follows:
 
Phase I, Intramural Support
o Support during the intramural phase will include a fellowship stipend 
as well as research and travel expenses based on the candidate"s years 
of postdoctoral experience and commensurate with the NIDDK intramural 
salary structure.   

Phase II, Extramural Support 
 
Total direct costs for salary and research support may not exceed $175,000 
per year plus fringe benefits.  
 
o Salary:  NIDDK will provide salary for the award recipient to the same 
extent as that for K01, K08, and K23 awards at the time of award 
transition (currently $75,000 per year plus fringe benefits) for a 
minimum of 75 percent effort.  The total salary requested must be based 
on a full-time, 12-month staff appointment.  It must be consistent both 
with the established salary structure at the institution and with 
salaries actually provided by the institution from its own funds to 
other staff members of equivalent qualifications, rank, and 
responsibilities in the department concerned.  The institution may 
supplement the NIH contribution up to a level that is consistent with 
the institution"s salary scale, however, supplementation may not be 
from federal funds unless specifically authorized by the federal 
program from which such funds are derived. Institutional 
supplementation of salary must not require extra duties or 
responsibilities that would interfere with the purpose of the K22 
Award. 

o Research Support:  NIDDK will provide up to $100,000 per year for (a) 
research expenses, such as supplies, equipment, and technical 
personnel, (b) travel to research meetings or training, and (c) 
statistical services, including personnel and computer time. 

o Ancillary Personnel Support:  Salary for secretarial and administrative 
assistance is not allowed.

o Facilities and Administrative Costs (F&A):  F&A costs will be 
reimbursed at 8% of modified total direct costs.
 
Activating the Extramural Support Phase
 
The candidate must receive approval in writing from NIDDK and must be 
accepted by an extramural institution in a tenure-track or equivalent 
position in order to activate the extramural support phase.  The extramural 
institution will submit an application on behalf of the candidate for the 
extramural phase of support, using Form PHS 398  
(http://grants.nih.gov/grants/funding/phs398/phs398.html and 
http://grants.nih.gov/grants/funding/phs398/instructions2/p1_preparing
_individual_CDA_app.htm).  The application 
should include a letter from the department or division chairman describing 
the institution"s plan for career development. The application submitted by 
the awardee and the extramural institution will be evaluated by NIDDK 
extramural staff for completeness and responsiveness to the program.
 
Evaluation
 
Phase I: Intramural Support 
Each awardee will be evaluated for progress on an annual basis by the mentor, 
Laboratory or Branch Chief, and Scientific Director/Advisory Committee.  The 
second annual scientific review will also constitute the formal review to 
determine suitability for transition to the extramural phase of the award.
 
Phase II:  Extramural Support 
The awardee will be required to submit a Form PHS 2590 non-competing 
continuation application for the final year of extramural support 
http://grants.nih.gov/grants/funding/2590/2590.htm
and http://grants.nih.gov/grants/funding/2590/instructions2/
iv_cda_progress_report.htm.  The application should provide a description 
of the research and career progress of the awardee, including: 
1) publications in press or submitted, 2) current investigator-initiated 
research grant support, and 3) all applications submitted for investigator-
initiated research grant support.  It should also include a description of the 
extramural institution"s commitment to development of the awardee"s career. 
 
After the completion of this award, periodic updates on various aspects of 
employment history, publications, support from research grants or contracts, 
honors and awards, professional activities, and other information helpful in 
evaluating the impact of the program will be solicited from awardees by 
NIDDK"s Intramural Fellowship Office.

WHERE TO SEND INQUIRIES
 
We actively encourage inquiries concerning this Program Announcement and 
welcome the opportunity to answer questions from potential applicants.  
Inquiries generally fall into two broad areas:  
 
Direct questions about the intramural phase, including the initial 
application process and opportunities for scientific research within the 
intramural program to: 

Louis Simchowitz, M.D., M.B.A.
Director, Office of Fellow Recruitment and Career Development
National Institute of Diabetes and Digestive and Kidney Diseases
Building 10, Room 9N-208
10 Center Drive
Bethesda, MD  20892
301-451-9808 (voice)
ls347f@nih.gov
 
Direct questions about the extramural phase as follows:
for scientific/research issues, to:

Judith Podskalny, Ph.D.
Program Director for Training and Career Development
Digestive Diseases Center and SBIR/STTR
National Institute of Diabetes and Digestive and Kidney Diseases
6707 Democracy Boulevard, Room 667 
Bethesda, MD  20892-5450
301-594-8876 (voice)
301-480-8300 (fax)
jp53s@nih.gov

for peer-review issues, to:

Francisco O. Calvo, Ph.D.
Chief, Review Branch
Division of Extramural Activities
National Institute of Diabetes and Digestive and Kidney Diseases
6707 Democracy Boulevard, Rm. 752
Bethesda, MD  20892-5452
(for express/courier service: Bethesda, MD 20817)
301-594-8897 (voice)
301-480-3505 (fax)
fc15y@nih.gov

for financial/grants management issues, to: 

Ms. Donna Huggins
Supervisory Grants Management Specialist
Grants Management Branch, DEA
National Institute of Diabetes and Digestive and Kidney Diseases
6707 Democracy Blvd., Room 711 
Bethesda, MD  20892-5456
(For Express Mail Use Zip Code 20817)
301-594-8848 (voice)
301-480-3504 (fax)
dh48v@nih.gov

SUBMITTING AN APPLICATION
 
Individuals interested in applying for the NIDDK K22 Award should contact Dr. 
Louis Simchowitz, Director of the Fellowship Office, as early as conveniently 
possible.  This contact is required to initiate the process of identifying a 
mentor within the NIDDK Intramural Program, if one has not already been 
selected by the candidate, and to facilitate the application process.  After 
forwarding a cover letter and curriculum vitae, some applicants will be 
invited to visit the NIH campus, at NIDDK"s expense, to meet with potential 
NIDDK mentors and other NIH investigators prior to submission of the full 
application.  The rationale is to uncover and maximize synergies between 
candidates and NIH investigators so that together they can develop a broader 
approach and more comprehensive research plan for the intramural training 
phase at NIDDK.  

Information about principal investigators and laboratories in the NIDDK 
Intramural Research Program may be found at 
http://www.niddk.nih.gov/intram/intram.htm or through a keyword search at 
http://intramural.nih.gov/search (choose option 3 and select NIDDK from the 
pull-down menu). 
 
The application must include information regarding the candidate"s long-term 
research career plan, including descriptions of any proposed formal course 
work, a research training plan for the intramural phase, and the intramural 
mentor"s statement of support.
 
Applications must be prepared using the PHS 398 research grant application 
instructions and forms (rev. 5/2001), following the instructions in Section 
IV, with the modifications noted below.  The PHS 398 is available at 
http://grants.nih.gov/grants/funding/phs398/phs398.html 
in an interactive format.  For further assistance contact GrantsInfo, 
Telephone (301) 435-0714, Email:  GrantsInfo@nih.gov.
 
APPLICATION RECEIPT DATES: Applications submitted in response to this program 
announcement will be accepted at the standard application deadlines for 
Research Career Awards (K series), which are available at 
http://grants.nih.gov/grants/dates.htm.  Please refer to the single annual 
set date on the face page of this announcement.  
 
SUPPLEMENTAL GUIDELINES
 
The application must address the following issues:
 
Candidate
o Commitment to a career in biomedical research 
o Potential to develop into a successful independent investigator
o Ability to work with other scientists in an interactive research 
environment
o Immediate and long-term career objectives, explaining how the award 
will contribute to their attainment.
o Career Development Plan: Applicants should describe their overall 
career goals and plans for continued scientific development in their 
research career, including the need for any courses, research 
techniques or methodology.
 
Letters of Recommendation
Three sealed letters of reference addressing the candidate"s potential for a 
research career from well-established basic or clinical scientists must be 
included.  One letter should be from the most recent mentor in a postdoctoral 
research setting and one letter from the applicant"s dissertation/thesis 
advisor, if applicable.  The letters should address the following issues:
o applicant"s past contributions and scientific achievements
o applicant"s special potential to pursue and develop an independent 
research program
o applicant"s ability to work with other scientists in various 
interactive situations (e.g., seminars and journal clubs), on 
collaborative research projects, and with support staff (e.g., 
technicians, secretaries).
 
Research Plan
Describe the research plan as outlined in Form PHS 398 including sections on 
the Specific Aims, Background and Significance, Progress Report/Preliminary 
Studies, Research Design and Methods.  The research plan should describe the 
use of a basic or clinical approach to a biomedical question.  The scientific 
objectives and specific aims should describe research plans that are 
sufficient to justify five years of support.  Applicants should also provide 
future research directions for the extramural support phase, i.e., what are 
the broad research goals and potential avenues of research that would be 
enhanced by the specific research project.  
 
Mentor"s Training Plan (Intramural Phase)
The intramural NIDDK mentor must describe the elements of research training 
planned for the candidate, including any formal course-work, and specify how 
the candidate"s scientific independence and professional development will be 
promoted. 
 
SPECIFIC INSTRUCTIONS  
Follow the instructions in Section IV for PHS 398, with the modifications 
noted below.
 
o Identify the application as a response to this Program Announcement, 
check "YES" on page 1, item 2 of the application and enter the Program 
Announcement number listed at the top of the face page of this document 
and "NIDDK Career Transition Award (K22)."
o Enter in item 6 (Dates of Proposed Period of Support) the combined 
years of support needed to complete the intramural and the extramural 
phases of the NIDDK Career Transition Award.
o Do not complete items 9-13 and 15 on the face page.
o Provide applicant"s signature in item 14, a signature is not required 
for item 15.
o Utilize "Substitute Form Page 3: Research Career Award Table of 
Contents."
o Provide "Form Page 4:  Detailed Budget for Initial Budget Period."
o Provide an official certified transcript covering medical school or the 
graduate school level of education.
o Include a biographical sketch of the candidate and the mentor.
o Do not submit a Checklist Page.
 
Budget for Intramural Phase
Cost justifications should be developed in accordance with the Budget 
instructions in form PHS 398.  Do not provide any dollar figures in the 
application.  The candidate should work with the proposed NIDDK mentor to 
devise a reasonable budget for the intramural phase.  The final budget will 
be negotiated when a selected candidate accepts a position and will be within 
the allowable costs specified above.
 
Budget for Extramural Phase
For candidates who receive approval for transition to the Extramural Phase, a 
budget will be submitted at that time as part of Form PHS 398.
 
SENDING AN APPLICATION TO THE NIH: Submit a signed, typewritten original of 
the application, including the Checklist, and three signed, photocopies, in 
one package to:
 
Center For Scientific Review
National Institutes Of Health
6701 Rockledge Drive, Room 1040, MSC 7710
Bethesda, MD  20892-7710
Bethesda, MD  20817 (for express/courier service)
 
At the time of submission, two additional copies of the application must be 
sent to:

Francisco O. Calvo, Ph.D.
Chief, Review Branch
Division of Extramural Activities, NIDDK
6707 Democracy Boulevard, Rm. 752 MSC 5452
Bethesda, MD 20892-5452
(for express/courier service: Bethesda, MD 20817)
 
REVIEW CONSIDERATIONS

Applications submitted for this Program Announcement will be assigned on the 
basis of established PHS referral guidelines.  An appropriate scientific 
review group convened by NIDDK in accordance with the standard NIH peer 
review procedures (http://www.csr.nih.gov/refrev.htm) will evaluate 
applications for scientific and technical merit.  

REVIEW CRITERIA FOR THE INTRAMURAL SUPPORT PHASE
 
Candidate
o Commitment to an independent research career.
o Potential to develop as an outstanding scientist who will make 
significant contributions to the field.
o Quality and breadth of prior scientific training and experience 
include, where appropriate, the record of previous research support and 
publications. 
 
Career Development and Training Plan
o Appropriateness of the proposed training experience and intramural 
research environment to the candidate"s career development, considering 
the candidate"s goals and prior experience. 
o Consistency of the career development plan with the candidate"s 
research plan and potential for contributing to the scientific 
literature.
o Logical sequence and scientific rigor of the intramural training plan 
with the candidate"s research and career plans.

Mentor
o Research qualifications and previous experience/training record as a 
research supervisor. 
o Adequacy of the nature and extent of supervision that will occur during 
the proposed award period.
o Appropriateness of the mentor"s research interests and qualifications 
to the career development needs of the candidate.
o Details of the proposed mentoring plan.
 
Research Plan
o Usefulness of the research plan as a vehicle for enhancing research 
skills necessary to fulfill the objectives of the career development 
plan.
o Scientific and technical merit of the research question, experimental 
design, and methodology, judged in the context of the candidate"s 
proposed career objectives. 
 
Review Criteria for the Extramural Support Phase

These criteria will be applied to the evaluation that will take place at the 
end of the second year of intramural support.

o Quality of research and career progress to date as evidenced by the 
record of scientific publications, receipt of honors and awards, and 
recognition by peers and prestigious professional societies.
o Extent of the extramural institution"s provision of resources in 
support of the awardee"s research program and the nature of its 
commitment to the awardee"s career development.
o Appropriateness of the budget for the scope of the research and 
proposed training activities. 
 
SELECTION AND AWARD PROCEDURES
 
Funding decisions will be made based on priority score ranking, intramural 
program needs, and secondary review by the National Advisory Council for 
NIDDK.
 
REQUIRED FEDERAL CITATIONS 
 
INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS:  It 
is the policy of the NIH that women and members of minority groups and their 
sub-populations must be included in all NIH-supported biomedical and 
behavioral research projects involving human subjects, unless a clear and 
compelling rationale and justification are provided 
indicating that inclusion is inappropriate with respect to the health of the 
subjects or the purpose of the research.  This policy results from the NIH 
Revitalization Act of 1993 (Section 492B of Public Law 103-43). 
 
All investigators proposing research involving human subjects should read the 
UPDATED "NIH Guidelines for Inclusion of Women and Minorities as Subjects in 
Clinical Research," published in the NIH Guide for Grants and Contracts on 
August 2, 2000 
(http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-048.html), a 
complete copy of the updated Guidelines is available at 
http://grants.nih.gov/grants/funding/women_min/guidelines_update.htm.  The 
revisions relate to NIH defined Phase III clinical trials and require: a) all 
applications or proposals and/or protocols to provide a description of plans 
to conduct analyses, as appropriate, to address differences by sex/gender 
and/or racial/ethnic groups, including subgroups if applicable, and b) all 
investigators to report accrual, and to conduct and report analyses, as 
appropriate, by sex/gender and/or racial/ethnic group differences.
 
INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS:  
It is the policy of NIH that children (i.e., individuals under the age of 21) 
must be included in all human subjects research, conducted or supported by 
the NIH, unless there are scientific and ethical reasons not to include them.  
This policy applies to all initial (Type 1) applications submitted for 
receipt dates after October 1, 1998.
 
All investigators proposing research involving human subjects should read the 
"NIH Policy and Guidelines on the Inclusion of Children as Participants in 
Research Involving Human Subjects" that was published in the NIH Guide for 
Grants and Contracts, March 6, 1998, and is 
available at the following URL address:  
http://grants.nih.gov/grants/guide/notice-files/not98-024.html.
 
REQUIRED EDUCATION ON THE PROTECTION OF HUMAN SUBJECT PARTICIPANTS:  NIH 
policy requires education on the protection of human subject participants for 
all investigators submitting NIH proposals for research involving human 
subjects. This policy announcement is found in the NIH Guide for Grants and 
Contracts Announcement dated June 5, 2000, at the following website:  
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html.
 
PUBLIC ACCESS TO RESEARCH DATA THROUGH THE FREEDOM OF INFORMATION ACT:  The 
Office of Management and Budget (OMB) Circular A-110 has been revised to 
provide public access to research data through the Freedom of Information Act 
(FOIA) under some circumstances.  Data that are (1) first produced in a 
project that is supported in whole or in part with Federal funds and (2) 
cited publicly and officially by a Federal agency in support of an action 
that has the force and effect of law (i.e., a regulation) may be accessed 
through FOIA.  It is important for applicants to understand the basic scope 
of this amendment.  NIH has 
provided guidance at:  
http://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm.
 
Applicants may wish to place data collected under this Program Announcement 
in a public archive, which can provide protections for the data and manage 
the distribution for an indefinite period of time.  If so, the application 
should include a description of the archiving plan in the study design and 
include information about this in the budget justification section of the 
application. In addition, applicants should think about how to structure 
informed consent statements and other human subjects procedures given the 
potential for wider use of data collected under this award.  
 
URLS IN NIH GRANT APPLICATIONS OR APPENDICES:  All applications and proposals 
for NIH funding must be self-contained within specified page limitations.  
Unless otherwise specified in an NIH solicitation, internet addresses (URLs) 
should not be used to provide information necessary to the review because 
reviewers are under no obligation to view the Internet sites.  Reviewers are 
cautioned that their anonymity may be compromised when they directly access 
an Internet site. 
 
HEALTHY PEOPLE 2010:  The Public Health Service (PHS) is committed to 
achieving the health promotion and disease prevention objectives of "Healthy 
People 2010," a PHS led national activity for setting priority areas.  This 
Program Announcement, "NIDDK CAREER TRANSITION AWARD (K22)," is related to 
one or more of the priority areas.  Potential applicants may obtain a copy of 
"Healthy People 2010" at http://www.health.gov/healthypeople.
 
AUTHORITY AND REGULATIONS: This program is described in the Catalog of 
Federal Domestic Assistance No. 93.847, 93.848, and 93.849.  Awards are made 
under authorization of sections 301 and 405 of the Public Health Service Act 
as amended (42 USC 241 and 284) and administered under NIH grants policies 
and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92.  This program 
is not subject to the intergovernmental review requirements of Executive 
Order 12372 or Health Systems Agency review.
 
The PHS strongly encourages all grant recipients to provide a smoke-free 
workplace and discourage the use of all tobacco products.  In addition, 
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in 
certain facilities (or in some cases, any portion of a facility) in which 
regular or routine education, library, day care, health care, or early 
childhood development services are provided to children.  This is consistent 
with the PHS mission to protect and advance the physical and mental health of 
the American people.



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