Full Text PA-95-062 FELLOWSHIPS AND CAREER DEVELOPMENT IN INFLAMMATORY BOWEL DISEASE RESEARCH NIH GUIDE, Volume 24, Number 17, May 19, 1995 PA NUMBER: PA-95-062 P.T. 44 Keywords: Digestive Diseases & Disorders Inflammation National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Allergy and Infectious Diseases PURPOSE The Division of Digestive Diseases and Nutrition of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Division of Allergy, Immunology, and Transplantation of the National Institute of Allergy and Infectious Diseases (NIAID) invite applications for individual National Research Service Award fellowships (F32s) or Mentored Clinical Scientist Development Awards (K08s) from physicians and basic scientists interested in pursuing research related to inflammatory bowel disease (IBD). The intent of this Program Announcement (PA) is to encourage research and career development for individuals with a strong commitment to a research career in the area of the inflammatory bowel diseases, either in one of the basic sciences relevant to IBD or, more specifically, in work aimed at either Crohn's disease or ulcerative colitis. Research related to the role of the immune system in the pathogenesis and/or treatment of these diseases is of particular interest. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This PA, Fellowships and Career Development in Inflammatory Bowel Disease (IBD) Research, is related to the priority area of chronic disabling conditions. Potential applicants may obtain a copy of "Healthy People 2000 (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Applications for F32 awards may be submitted by domestic and foreign for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Applications for K08 awards may only be submitted by domestic organizations. Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as principal investigators. Applicants for both NRSA fellowships and Mentored Clinical Scientist Development Awards (K08) must be U.S. citizens or permanent residents of the United States. Grant funds are for research and career development only and may not be used for the support of clinical training or clinical services. K08 applicants must have received a clinical degree, or its equivalent, have completed residency requirements, and must not have previously been principal investigator on a research project grant (R01), or its equivalent. F32 applicants must have received the Ph.D., M.D., or equivalent degree prior to the beginning date of their appointment. NRSA postdoctoral support is limited to three years. MECHANISM OF SUPPORT Support of this program will be through the Individual National Research Service Award (F32) and the Mentored Clinical Scientist Development Award (K08). Details on each of these mechanisms are available from the Division of Research Grants, Office of Grants Information, 6701 Rockledge Drive, Room 3032, MSC 7762, Bethesda, MD 20892-7762, telephone (301) 710-0267. RESEARCH OBJECTIVES The objective of this program announcement is to encourage individuals to pursue research careers in the area of inflammatory bowel disease in order to increase the number of trained physicians and basic scientists interested in pursuing research related to the elucidation of the pathogenesis, progression, and treatment of inflammatory bowel disease. It has become clear recently that inflammatory bowel diseases may be caused by dysregulation of the immune system. Training either in the basic science areas of immunology, cell biology, or genetics as they relate to IBD or in the clinical areas of the diagnosis and treatment for Crohn's or ulcerative colitis are encouraged. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification is provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This new policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43) and supersedes and strengthens the previous policies (Concerning the Inclusion of Women in Study Populations, and Concerning the Inclusion of Minorities in Study Populations), which have been in effect since 1990. The new policy contains some provisions that are substantially different from the 1990 policies. All investigators proposing research involving human subjects should read the "NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical Research," which have been published in the Federal Register of March 28, 1994 (FR 59 14508-14513) and reprinted in the NIH Guide for Grants and Contracts, Volume 23, Number 11, March 18, 1994. Investigators also may obtain copies of the policy from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. APPLICATION PROCEDURES Applications for K08 awards are to be submitted on the grant application form PHS 398 (rev. 9/91) and will be accepted at the standard application deadlines as indicated in the application kit. Applications for NRSAs are to be submitted on the grant application form PHS 416-1 (rev. 10/91) and will be accepted at the standard application deadlines as indicated in the application kit. Both application kits are available at most institutional offices of sponsored research and may be obtained from the Office of Grants Information, Division of Research Grants, National Institutes of Health, 6701 Rockledge Drive, Room 3032, MSC 7762, Bethesda, MD 20892-7762, telephone (301) 710-0267. The title and number of the program announcement must be typed in Section 2a on the face page of the application. Applications must include three selaed letters of recommendations address ing the candidate's potential for a research career. Applications without the required number of letters of recommendations will be considered incomplete and and will be returned without review. For K08 applications, the completed original application and five legible copies must be sent or delivered to: DIVISION OF RESEARCH GRANTS NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) For F32 applications, the completed original application and two legible copies must be sent or delivered to the same address. REVIEW CONSIDERATIONS Applications will be assigned on the basis of established PHS referral guidelines. K08 applications will be reviewed for scientific and technical merit by review groups of the Institute to which they are assigned in accordance with standard NIH peer review procedures. NRSA fellowship applications will be reviewed for scientific and technical merit by review groups within the Division of Research Grants. Following scientific-technical review, K08 applications will receive a second-level review by the appropriate National Advisory Councils; the F32 applications will receive a second-level review by staff of the Institutes. The general review criteria for applications received in response to this PA are the same as those for unsolicited NRSA fellowship and K08 applications. Specifically these are: o the applicant's potential for and commitment to a research career in the areas specified by this PA; o training potential of the proposed research; o scientific merit of the proposed research; and o qualifications, research expertise, and training experience of the sponsor along with adequate institutional commitment to ensure completion of the proposed training. The initial review group, either in the Institute for K08 applications, or in the DRG for NRSA fellowship applications, will also examine the provisions for the protection of human and animal subjects and the safety of the research environment. AWARD CRITERIA Applications will compete for available funds with all other approved applications assigned to that IC. The following will be considered in making funding decisions: quality of the proposed project as determined by peer review, the availability of funds, and program priority. INQUIRIES Inquiries are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Judith M. Podskalny, Ph.D. Division of Digestive Diseases and Nutrition National Institute of Diabetes and Digestive and Kidney Diseases Natcher Building, Room 6AN-12E 45 Center Drive MSC 6600 Bethesda, MD 20892-6600 Telephone: (301) 594-8876 FAX: (301) 480-8300 Email: jp53s@nih.gov Lawrence Prograis, M.D. Division of Allergy, Immunology, and Transplantation National Institute of Allergy and Infectious Diseases Solar Building, Room 4A24 6003 Executive Boulevard MSC 7640 Bethesda, MD 20892-7640 Telephone: (301) 496-1886 FAX: (301) 402-2571 Email: lp13r@nih.gov Direct inquiries regarding fiscal and administrative matters to: Mrs. Nancy Dixon Division of Extramural Activities National Institute of Diabetes and Digestive and Kidney Diseases Natcher Building, Room 6AN-44C 45 Center Drive MSC 6600 Bethesda, MD 20982-6600 Telephone: (301) 594-8854 Email: nd11m@nih.gov Ms. Jacqueline Johnson Grants Management Branch National Institute of Allergy and Infectious Diseases Solar Building, Room 4B26 6003 Executive Boulevard MSC 7610 Bethesda, MD 20892-7610 Email: jj19e@nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.848 and 93.855. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant and contract recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routing education, library, day care, health care or early childhood development services are provided to children. This is consistent with the phs mission to protect and advance the physical and mental health of the american people. .
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