LABORATORY TESTS OF BLOOD AND URINE SAMPLES FROM THE CPEP CLINICALTRIAL NIH GUIDE, Volume 24, Number 8, March 3, 1995 RFP AVAILABLE: NICHD-DESPR-95-14 P.T. 34 Keywords: Clinical Trial Biological Resources National Institute of Child Health and Human Development As a part of the Trial of Calcium for Preeclampsia Prevention (CPEP), the National Institute of Child Health and Human Development (NICHD) is planning to (1) compare urinary excretion of calcium and related nutrients in preeclamptic women before and after the diagnosis of preeclampsia to that in normal pregnant women at comparable gestational ages, and determine the effect of oral calcium supplementation on the excretion of these substances; (2) determine the presence or absence of proteinuria not previously ascertained in up to 125 urine specimens obtained from normal women and from women with gestational hypertension within seven days of documented hypertension; and (3) measure the quantity of elemental calcium in each of up to 100 study medication tablets for purposes of quality control. The comparison of urinary excretion of calcium and related nutrients will be a nested case control study using stored urine specimens collected at specified times during pregnancy and at the diagnosis of preeclampsia from pregnant women participating in CPEP. CPEP is a randomized clinical trial designed to determine whether oral calcium supplementation will prevent preeclampsia. The Contractor will be expected to measure calcium, sodium, potassium, chloride, magnesium, zinc, phosphorus, urea nitrogen, and creatinine in approximately 5912 urine specimens selected by the Project Officer over the course of one year. Measurements of protein and creatinine in up to 125 additional urine specimens and calcium content of up to 100 study medication tablets must also be completed within the same year. INQUIRIES This announcement is a new solicitation. The issuance of this Request for Proposals (RFP) will be on or about March 6, 1995, and proposals are due by 4:00 p.m. (local time), May 2, 1995. The short-form version of the RFP will be provided first, which includes only the Statement of Work, Technical Reporting Requirements, Background Information, and the Evaluation Criteria to be used for selection of the awardee. After examining this, a full-text version of the RFP must be requested, in writing, for those organizations interested in responding. FAX requests are acceptable. All requests must cite the RFP number and include two self-addressed mailing labels. All sources who consider themselves qualified are encouraged to submit a proposal. This advertisement does not commit the Government to make an award. Organizations desiring a copy of the short-form RFP may send a written request to: Mrs. Lynn Salo Office of Grants and Contracts National Institute of Child Health and Human Development Executive Building, Room 7A07 6100 Executive Boulevard MSC 7510 Bethesda, MD 20892-7510 Telephone: (301) 496-4611 FAX: (301) 402-3676 .
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