PASSIVE IMMUNIZATION:  TREATMENT OF RABIES VIRUS INFECTION WITH HUMANMONOCLONAL ANTIBODIES

NIH GUIDE, Volume 24, Number 4, February 3, 1995

RFP AVAILABLE:  NIH-NIDR-2-95-6R

P.T. 34

Keywords:
  Viral Studies (Virology) 
  Monoclonal Antibodies 

National Institute of Dental Research

The National Institute of Dental Research (NIDR) has a requirement
for the generation of rabies virus neutralizing human monoclonal
antibody (mAbs), preferentially of the high affinity IgG isotype, so
that a "cocktail" of several neutralizing human mAbs can be prepared
against multiple antigenic sites on the viral glycoprotein (GP) and
ribonucleoprotein (RNP) complex.  The specific objectives of the
project are:  (1) to generate at least 15 high affinity virus-
neutralizing human mAbs against various antigenic determinants on
rabies virus using human hybridoma technology, and (2) to show that
these mAbs protect animals against lethal rabies challenge.  Offerors
must have access to blood from healthy donors immunized with rabies
vaccine and must demonstrate previous successful establishment of
mAbs.

INQUIRIES

Request for Proposals (RFP) NIH-NIDR-2-95-6R will be available
approximately February 17, 1995, with proposals due on or about March
30, 1995.  Requests for the RFP may be addressed to:

Ms. Marion L. Blevins
Contract Management Section
National Institute of Dental Research
Natcher Building, Room 4AN-44D
Bethesda, MD  20892

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