PREPARATION OF RADIOLABELED SPHINGOLIPIDS NIH GUIDE, Volume 21, Number 43, November 27, 1992 RFP AVAILABLE: NIH-NINDS-93-03 P.T. 34 Keywords: Chemical Synthesis Chemistry, Organic National Institute of Neurological Disorders and Stroke The National Institute of Neurological Disorders and Stroke (NINDS), NIH, has a requirement for the preparation and delivery of certain synthesized radiolabeled sphingolipids needed to support basic and clinical investigations of Gaucher's disease, Niemann-Pick disease, and Fabry's disease conducted by staff of the Division of Intramural Research, NINDS. The Contractor shall be required to prepare and deliver: (a) a total of 3.0 grams of 14-C-glucocerebroside (1.0 gram during the basic contract period, and 1.0 gram during each option period) specifically labeled in the D-glucose portion of the molecule with a minimum specific activity of 1000 d.p.m. per nanomole; (b) 1.0 gram of 14-C-sphingomyelin (to be delivered during the first option period) labeled in the choline portion of the molecule with a minimum specific activity of 1000 d.p.m. per nanomole; and (c) 1.0 gram of 14-C-ceramidetrihexoside (to be delivered during the second option period) labeled exclusively in the terminal molecule of galactose with a minimum specific activity of 1000 d.p.m. per nanomole. The labeled sphingolipids shall be synthesized with radiochemical purity and in the form of the naturally occurring stereoisomers. The homogeneity of each sphingolipid delivered shall be documented by elemental analysis, various physical methods including infrared, NMR, and mass spectroscopy, thin-layer or high-pressure liquid chromatography. The specific radioactivity of the various compounds shall be certified. Offerors will be required to provide evidence of their competence, ability, and prior experience in the synthesis of radioactive sphingolipids. This requirement represents a recompetition of work currently being performed under NINDS Contract No. N01-NS-0-2386, with Lipitek, Inc. It is expected that the incumbent Contractor will recompete. One award is anticipated. Award will be made on a fixed-price per deliverable basis. The basic contract will cover a 12-month term and will contain two fixed-price, one year options. This is not a Request for Proposals (RFP). RFP No. NIH-NINDS-93-03 will be issued on or about December 1, 1992, with January 29, 1993, set as a tentative closing date for receipt of proposals. To receive a copy of the RFP, submit a written request to the following address, and supply two self-addressed mailing labels: Contracts Management Branch, DEA National Institute of Neurological Disorders and Stroke Federal Building, Room 901 7550 Wisconsin Avenue Bethesda, MD 20892 Reference: RFP No. NIH-NINDS-93-03 This announcement does not commit the NINDS to make an award. All responsible sources may submit a proposal that will be considered by the agency. .
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