EVALUATION OF THE EFFECT OF A FAT MODIFIED DIET ON HORMONES DURINGADOLESCENCE



NIH GUIDE, Volume 21, Number 36, October 9, 1992



RFP AVAILABLE:  NCI-CN-25502-51



P.T. 34, AA



Keywords:

  Nutrition/Dietetics 

  Metabolism, Lipid 

  Hormones 



National Cancer Institute



The National Cancer Institute (NCI), Prevention and Control Contracts

Section (PCCS), intends to issue a Request for Proposal (RFP)

NCI-CN-25502-51.  The Division of Cancer Prevention and Control, NCI,

is conducting a study to evaluate the effect of a fat-modified diet

on hormones during childhood and adolescence.  The study is being

performed ancillary to the Diet Intervention Study in Children

(DISC), a randomized clinical trial sponsored by the Division of

Epidemiology and Clinical Applications, National Heart, Lung and

Blood Institute (NHLBI).  The objectives of DISC are to determine

whether a fat-modified diet during childhood and adolescence will

lower LDL-cholesterol and to assess the feasibility and safety of

this diet.  The objectives of the NCI ancillary study are to evaluate

the effect of this fat-modified diet on sex hormones and to correlate

characteristics of children and adolescents, such as age, Tanner

stage, anthropometry, diet, and physical activity, with sex hormone

levels.  This solicitation seeks a contractor to store serum

specimens collected for DISC, develop and issue an RFP for a

laboratory to perform serum hormone assays, evaluate the offerors'

proposals, award a subcontract to the best qualified laboratory

offering the best buy for the Government, and monitor the laboratory

to ensure high quality work and fulfillment of contractual

obligations.  This RFP will be available on or about October 2, 1992,

with responses due approximately six weeks thereafter.  No collect

calls will be accepted.



Copies of the RFP may be obtained by sending a written request to:



Christine L. Ptak, Contract Specialist

Research Contracts Branch, PCCS

National Cancer Institute

Executive Plaza South, Room 635

9000 Rockville Pike

Bethesda, MD  20892

Telephone:  (301) 496-8603



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