SCREENING FOR AGENTS AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS NIH GUIDE, Volume 21, Number 22, June 12, 1992 RFP AVAILABLE: NCI-CM-37818-28 P.T. 34 Keywords: AIDS Screening of Drugs/Agents Antivirals Cell Lines National Cancer Institute The National Cancer Institute (NCI), Division of Cancer Treatment, Developmental Therapeutics Program, Antiviral Evaluations Branch, is seeking an organization to provide assistance in the primary screening of experimental agents utilizing the HTLV/LAV (human AIDS virus). An organization is sought that will supply the necessary equipment, personnel, and facilities to conduct screening on the scale of 20,000 tests per year. The tasks will include maintaining and expanding one or more cell lines and the virus necessary to infect these cells, the preparation of experimental agents for testing, and the collection and submission of data. The project will primarily involve cell culture, although approximately 20 percent of the work will involve in vitro detailed agent testing, and less than 10 percent of the work will involve in vivo testing with murine leukemia virus. It is anticipated that one cost-reimbursement contract, completion form, will be awarded as a result of the solicitation. This contract is planned to be incrementally funded over a five-year period. The proposed contract project represents a recompetition of Southern Research Institute, N01-CM-87237. Because of the nature of work involving live human immunodeficiency virus (HIV), offerors must show evidence at the time of the best and final offer that P-3 level biocontainment facilities are available for use on this project. This project requires that the following restriction be applied. "The NCI signs legally binding agreements with certain suppliers (often pharmaceutical or chemical companies) that state that all information on compounds submitted by the supplier will be held confidential. The successful offeror will be expected to test such commercially confidential (discreet) agents. The NCI believes that the compound cannot be sent to potential competitors of the supplier, and thus pharmaceutical and chemical companies must be excluded from the competition. For purposes of this exclusion, a pharmaceutical or chemical company is defined as an organization that manufactures and/or sells drugs and chemicals to the general public for profit." All responsible sources may submit a proposal that shall be considered by the NCI. This announcement is not a Request for Proposals (RFP). RFP No. NCI-CM-37818-28 will be available on or about June 12, 1992, with a response date of July 27, 1992, for the receipt of proposals. All copies of the RFP may be obtained by written request to: Ms. Carolyn Barker Contract Specialist, Research Contracts Branch Treatment Contracts Section Executive Plaza South, Room 603 9000 Rockville Pike Bethesda, MD 20892 No collect calls will be accepted. .
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