PEPTIDE ANTAGONISTS OF LHRH AS GONADOTROPIN INHIBITORS NIH GUIDE, Volume 21, Number 17, May 8, 1992 RFP AVAILABLE: NICHD-CD-92-17 P.T. 34 Keywords: Contraceptives Peptides Drug Design National Institute of Child Health and Human Development The Contraceptive Development Branch of the Center for Population Research, National Institute of Child Health and Human Development (NICHD), is interested in stimulating further investigations into the design, synthesis, and testing of peptide antagonists of LHRH as gonadotropin inhibitors. Such investigations will also involve the biological evaluation of the peptides, preferably by the contractor. The Contraceptive Development Branch is prepared, however, to evaluate such peptides if the contractor is unable to do so. The goal is to obtain LHRH antagonists that are more potent than those currently available, and are devoid of histamine releasing properties. Proposals merely to collect peptides from various sources And/or only perform biological assays are excluded from consideration at this time. Organizations must have adequate facilities to conduct the proposed peptide program. All responsible sources may submit an offer that shall be considered by the agency. It is anticipated that four cost- reimbursement, incrementally funded type contracts will be awarded under the Request for Proposals (RFP) for a period of two years, beginning December 1, 1992. The Government estimates the effort for each contract to be approximately 3.5 staff years annually. This announcement is not an RFP. RFP-NICHD-CD-92-17 will be issued on or about May 13, 1992. Proposals will be due approximately 60 days thereafter. Copies of the RFP may be obtained by sending a written request to the address listed below. Please enclose a self-addressed label. Requests may also be made by FAX: (301) 402-0915. Paul J. Duska, Contracting Officer Contracts Management Branch Office of Grants and Contracts National Institute of Child Health and Human Development Executive Plaza North, Room 610 9000 Rockville Pike Bethesda, MD 20892 .
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