TESTING INTERVENTIONS TO IMPROVE ADHERENCE TO PHARMACOLOGICAL TREATMENT REGIMENS Release Date: December 15, 1999 NOTICE: OD-00-005 National Institutes of Health The National Institutes of Health (NIH) is implementing a trans-institute initiative to improve adherence to therapeutic regimens. The Office of Behavioral and Social Sciences Research, Office of the Director, NIH (OBSSR), and several NIH Institutes are developing a Request for Applications (RFA) to encourage behavioral and social research on the effectiveness of interventions to improve adherence to therapeutic regimens involving pharmacological treatments in various settings. The forthcoming RFA will solicit regular research (R01) grant applications where (1) the therapeutic regimen is for an existing illness or condition as opposed to a primary disease prevention or health promotion regimen and (2) the adherence intervention has been demonstrated to be effective in either (a) controlled settings (e.g., laboratories, clinical trials), (b) has been tested only with limited populations (e.g., small samples or samples from restricted populations) or with short periods of follow-up, or (c) has been researched on a health condition or treatment regimen different from that in the proposed research. In addition, the RFA will encourage research on how to adjust interventions to take into account the characteristics of different patient groups as well as patients suffering from and receiving treatments for multiple acute and/or chronic illnesses and conditions. The RFA will be an opportunity to conduct research cutting across the traditional boundaries of responsibility of the participating NIH Institutes and Centers (ICs). The planned release date for the RFA is in late January 2000, with applications being due in April 2000. OBSSR/NIH anticipates making available $3 million for approximately six awards in September 2000.The announcement will be published in the NIH Guide to Grants and Contracts in the usual manner. You may also be informed of the publication of the RFA and receive subsequent information by subscribing to the OBSSR’s automated e-mail service. To subscribe, please send a message addressed to listserv@list.nih.gov. Leave the subject line blank. The message body should read SUBscribe RFA-ADHERENCE-L [your full name]. The message is case sensitive, so capitalize as indicated! Don"t include the brackets. For example, for Robin Smith to subscribe, the message would read SUBscribe RFA- ADHERENCE-L Robin Smith (omit the quotation marks). You will receive a confirmation of your subscription along with instructions on how to use the LISTSERV and how to unsubscribe. INQUIRIES Please direct general inquiries in regard to this notice to: Ronald P. Abeles, Ph.D. Office of Behavioral and Social Sciences Research Office of the Director National Institutes of Health Gateway Bldg., Rm. 2C234, MSC 9205 7201 Wisconsin Avenue Bethesda, MD 20892-9205 Telephone: 301-496-7859 Fax: 301-435-8779 E-mail: Abeles@nih.gov

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