COLLABORATIVE RESEARCH IN COMPUTATIONAL NEUROSCIENCE (CRCNS) INNOVATIVE APPROACHES TO SCIENCE AND ENGINEERING RESEARCH ON BRAIN FUNCTION: NSF 04-514 (REPLACES NSF 02-018) RELEASE DATE: November 6, 2003 NOTICE: NOT-NS-04-003 (See Replacement Notice NOT-NS-08-008) PARTICIPATING ORGANIZATIONS: National Science Foundation (NSF) (http://www.nsf.gov) Directorate for Computer and Information Science and Engineering Directorate for Biological Sciences Directorate for Social, Behavioral, and Economic Sciences Directorate for Engineering Directorate for Mathematical and Physical Sciences National Institutes of Health (NIH) (http://www.nih.gov) National Institute of Neurological Disorders and Stroke (NINDS) (http://www.ninds.nih.gov) National Institute of Mental Health (NIMH) (http://www.nimh.nih.gov) National Institute on Drug Abuse (NIDA) (http://www.nida.nih.gov) National Institute on Deafness and Other Communication Disorders (NIDCD) (http://www.nidcd.nih.gov) National Institute on Alcohol Abuse and Alcoholism (NIAAA) (http://www.niaaa.nih.gov) National Institute on Aging (NIA) (http://www.nia.nih.gov) National Eye Institute (NEI) (http://www.nei.nih.gov) National Institute of Biomedical Imaging and Bioengineering (NIBIB) (http://www.nibib.nih.gov) National Institute of Dental and Craniofacial Research (NIDCR) (http://www.nidcr.nih.gov) LETTER OF INTENT RECEIPT DATE (REQUIRED): December 10, 2003 December 1, 2004 December 1, 2005 PROPOSAL (APPLICATION) RECEIPT DATE: January 30, 2004 January 5, 2005 January 5, 2006 This Notice replaces Notice NOT-MH-01-014. http://grants.nih.gov/grants/guide/notice-files/NOT-MH-01-014.html This Notice announces a joint initiative, Collaborative Research in Computational Neuroscience (CRCNS), between five National Science Foundation (NSF) Directorates and nine participating National Institutes of Health (NIH) Institutes. The CRCNS announcement is released under NSF 04-514, http://www.nsf.gov/cgi-bin/getpub?nsf04514. This announcement supersedes NSF 02-018; Support Collaborative Research in Computational Neuroscience (CRCNS). This new announcement differs from the prior issuance in that it is effect for three years, and the scope of the solicitation is expanded to include the interests of other NIH Institutes and NSF Directorates. CRCNS will support innovative interdisciplinary research in computational neuroscience. Both agencies recognize the need for research that focuses on integrating computational models and methods with neuroscience. This solicitation is designed to encourage new collaborations at this interface. Appropriate scientific areas of investigations are those that are currently supported by NSF and NIH, or related to the missions of the two agencies. Computational neuroscience provides a theoretical foundation and set of technological approaches that may enhance our understanding of nervous system function by providing analytical and modeling tools that describe, traverse and integrate different levels of organization, spanning vast temporal and spatial scales and levels of abstraction. Computational approaches are needed in the study of neuroscience as the requirement for comprehensive analysis and interpretation of complex data sets becomes increasingly important. Collaborations among computer scientists, engineers, mathematicians, statisticians, theoreticians and experimental neurobiologists, are imperative to advance our understanding of the nervous system and mechanisms underlying brain disorders. The computational research that will be supported under this program must impact on, and relate to biological processes, and optimally generate hypotheses that are testable in biological studies. It is expected that, (1) applications will include collaborations between computational and/or modeling experts, and neuroscientists; (2) collaboration will involve a dynamic and, possibly, a protracted period of model development and refinement, and intense interaction among scientists and engineers from different disciplines; and (3) the development and testing of new models will provide a framework for the design of experiments and the generation of new hypotheses that can help reveal mechanisms underlying both normal and disease states of the nervous system. AWARD INFORMATION Estimated program budget, number of awards and average award size and duration are subject to the availability of funds. Award sizes are expected to range from $100,000 to $500,000 in total cost per year (including indirect costs), with durations of 3-5 years. Most awards will be on the smaller end of this range. The maximum budgets of awards funded by the NIH will be $250,000 per year in direct costs. The maximum budgets of awards funded by NSF will be $500,000 per year in total costs. Upon conclusion of the review process, meritorious applications may be recommended for funding by either the participating NSF Directorates or NIH Institutes, at the option of the agencies, not the applicant. PROPOSAL PREPARATION AND SUBMISSION INSTRUCTIONS Letters of Intent (Required): Letters of intent should be submitted via email to crcns- intent@nsf.gov. The subject line of the e-mail should include the PI's and the title of the project. The body of the email should include: 1. The names and institutions/organizations of PIs, CoPIs, and Senior Personnel 2. The title of the project 3. A 250-word abstract of the project Letters of Intent will be used by the program to guide the selection of reviewers. PIs should not expect feedback on their letters of intent, beyond acknowledgement of their receipt. Full Application Instructions: Applications submitted in response to this program announcement/solicitation should be prepared and submitted in accordance with the general guidelines contained in the NSF Grant Proposal Guide (GPG). Applications must be submitted to NSF, not the NIH. The complete text of the GPG is available electronically on the NSF Web Site at http://www.nsf.gov/cgi-bin/getpub?gpg. Paper copies of the GPG may be obtained from the NSF Publications Clearinghouse, telephone (301) 947-2722 or by e-mail from pubs@nsf.gov. Applicants are reminded to identify the program announcement number (04-514) in the program announcement block on the NSF Cover Sheet for Proposal to the National Science Foundation. Compliance with this announcement is critical to determining the relevant proposal processing guidelines. Failure to submit this information may delay processing. INQUIRIES Written and telephone inquiries are encouraged. Please see the NSF program announcement for names and contact information for each of the participating NSF Directorates and/or NIH Institutes at http://www.nsf.gov/cgi-bin/getpub?nsf04514.

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