HUMAN GENETIC RESOURCE CENTER: DNA AND CELL LINE REPOSITORY Release Date: March 6, 2002 NOTICE: NOT-NS-02-012 RFP Available: NIH-NINDS-RFP-02-03 National Institute of Neurological Disorders and Stroke (NINDS) (http://www.ninds.nih.gov) The National Institute of Neurological Disorders and Stroke (NINDS) has the stated mission to reduce the burden of neurological disease a burden borne by every age group, by every segment of society, by people all over the world. Within this mission falls gene discovery. Gene discovery elucidates the cause of some diseases, and also, the underlying pathogenesis of related disorders. Genetic studies of neurological disorders are increasing in number and complexity. Such studies require a large and diverse sample and accompanying information base. Thus, a repository of DNA samples, immortalized cell lines (from which DNA can be extracted continuously), and accompanying clinical and pedigree data is clearly an invaluable resource for the neuroscience community. This project is conceptually related to repositories in existence at other institutes at the NIH. To date, no such resource has been available to the investigators studying the genetics of Neurological diseases. An NINDS repository will allow receipt, storage, maintenance, standardization, quality control, and equitable, ethical distribution of DNA and other resources important to research in Neurological diseases. This will allow sharing of resources, as mandated by NIH policy, and thus will encourage work by junior investigators, investigators with novel approaches, and others not included in current collaborations, without excluding those who are established in their fields. It will ensure that research participants will be making a maximal contribution, and decrease duplicative sampling efforts. Personnel with established expertise in DNA preparation, lymphoblast immortalization/cell line preparation, data management, power analysis/statistical support for genetic studies, biological materials receipt/distribution, and subject identify protection, will be needed to perform this research. It is anticipated that one award may be made for a period of five years in September 2002. Request for Proposals (RFP) NIH-NINDS-02-03 will ONLY be AVAILABLE ELECTRONICALLY at either one of the following websites: http://www.FedBizOpps.gov/ or http://www.ninds.nih.gov/funding/currentrfps.htm, 15 or more calendar days after the issuance of this synopsis. OFFERORS ARE RESPONSIBLE FOR ROUTINELY CHECKING EITHER WEBSITE FOR ANY POSSIBLE SOLICITATION AMENDMENTS THAT MAY BE ISSUED. NO INDIVIDUAL NOTIFICATION OF ANY AMENDMENTS WILL BE PROVIDED. All responsible sources may submit a proposal which shall be considered by the agency. Refer to numbered note 26.**** INQUIRIES Inquiries may be directed to: Patricia S. Denney, Contracting Officer Contracts Management Branch National Institute of Neurological Disorders and Stroke Neuroscience Center, Room 3287 6001 Executive Boulevard, MSC 9531 Bethesda, MD 20892-9531 Tel: (301) 496-1813 Fax: (301) 402-4225 Email: PD22N@NIH.GOV

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