INSULATING BIOMATERIALS Release Date: December 7, 2001 NOTICE: NOT-NS-02-006 National Institute of Neurological Disorders and Stroke RFP AVAILABLE: NIH-NINDS-02-02 The National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, announces the availability of a Request for Proposals (RFP) to supports the development and evaluation of insulating biomaterials that function reliably over the lifetime of an implant recipient. Testing for these materials shall be done both in-vitro (under physiologic and accelerated test conditions) and in-vivo. These biomaterials shall be suitable for insulating silicon-based, micromachines microelectrode arrays and connecting wire microcables that are placed in the central nervous system. The Contractor shall develop and validate evaluation methods to test the long-term survival and biocompatibility of implanted devices protected using the developed insulating biomaterials. The goals of this research are to develop biomaterials for the long-term electrical insulation of implanted neural prostheses and to validate material preparation and processing technology for consistent reliable application of these materials. In-vivo and in-vitro studies will be conducted with a significant emphasis on chronic in-vivo evaluation. In-vitro evaluation will focus on already identified promising materials such as liquid-crystal polymers, silicones, and fluropolymers and other materials that show significant potential for this application. Methods for accelerated as well as non-accelerated in-vivo testing of insulating biomaterials will be developed and validated. These in-vivo test systems then will be used to test the most promising materials identified by in-vitro soak testing. Personnel with established expertise in bioengineering, biomaterials, and microelectronics will be needed to perform this research.. It is anticipated that one cost-reimbursement type contract will be made for a period of four years in September 2002. This is not a Request for Proposals (RFP). THIS SOLICITATION WILL BE AVAILABLE ELECTRONICALLY ONLY. It will be available electronically and may be accessed through the FedBizOpps (URL: http://www.fedbizopps.gov) or through the NINDS website at the following URL address: (http://www.ninds.nih.gov/funding/funding_announcements/RFP_all.htm) 15 or more calendar days after the issuance of this synopsis. OFFERORS ARE RESPONSIBLE FOR ROUTINELY CHECKING THIS WEBSITE FOR ANY POSSIBLE SOLICITATION AMENDMENTS THAT MAY BE ISSUED. NO INDIVIDUAL NOTIFICATION OF ANY AMENDMENTS WILL BE PROVIDED. All responsible sources may submit a proposal, which shall be considered by the agency. Inquiries may be directed to: Laurie A. Leonard, Contracting Officer Contracts Management Branch National Institute of Neurological Disorders and Stroke, NIH NeuroScience Center, Suite 3287 6001 Executive Boulevard, MSC 9531 Bethesda, Maryland 20892 301-496-1813 E-Mail: LL44S@NIH.GOV
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