Notice Number: NOT-HL-11-113
Release Date: July 29, 2010
Response Date: September 10, 2010
National Heart, Lung, and Blood Institute (NHLBI) (www.nhlbi.nih.gov)
This Notice is a Request for Information (RFI) for ideas to update and improve the structure of a National Heart, Lung and Blood Institute (NHLBI)-supported clinical research network of pulmonary and critical care investigators and to seek research ideas that have the most promise to improve outcomes in the intensive care unit.
NHLBI has supported the Acute Respiratory Distress Syndrome Clinical Trials Network (ARDSnet) since 1994. The Network has consisted of groups of clinical centers and a clinical coordinating center that together selected and designed trials, recruited patients, and published results. There have been three separate peer-reviewed Requests for Proposals (RFPs) that established, expanded, and/or renewed the ARDSnet.
A recent NHLBI workshop has recommended that a continued effort in clinical trials in ALI/ARDS is warranted (http://www.ncbi.nlm.nih.gov/pubmed/20224063?dopt=Citation). It is widely recognized, however, that clinical trials are labor intensive and time consuming and the burden may be escalating. The Institute of Medicine has published an analysis of NCI clinical trials network (http://www.iom.edu/Reports/2010/A-National-Cancer-Clinical-Trials-System-for-the-21st-Century-Reinvigorating-the-NCI-Cooperative.aspx) and suggested a number of improvements for efficiency and impact.
NHLBI requests input on new approaches to clinical trials that might be incorporated into a network, opinions on whether the scope of research questions previously addressed by ARDSnet should change, how input from the community and basic science might be fed into a network, and identification of the most important research questions that can improve patient outcomes in the intensive care unit.
This RFI invites the scientific community, health professionals, patient advocates, and the general public to provide comments and suggestions on the following issues. It is not necessary to answer all questions below. Please provide input on questions of interest.
To respond by September 10, 2010, please complete and submit the form on line at: http://www.surveymonkey.com/s/TRF6CRN
This RFI is for planning purposes only and should not be construed as a solicitation for applications or proposals and/or as an obligation in any way on the part of the United States (U.S.) Federal government. The Federal government will not pay for the preparation of any information submitted and/or for the government's use of that information. Additionally, the government cannot guarantee the confidentiality of the information provided.
Responses to this RFI are voluntary and may be anonymous. Any identifiers (e.g., names, institutions, e-mail addresses, etc) will be removed when responses are compiled. Only the processed, anonymized results will be shared internally with scientific working groups convened by the NIH, as appropriate. Proprietary, classified, confidential, or sensitive information should not be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
Questions about this request for information may be directed to:
Andrea L Harabin, Ph.D.
Critical Care and Acute Lung Injury
Division of Lung Diseases
National Heart, Lung, and Blood Institute
Two Rockledge Centre, Room 9104
6701 Rockledge Drive
Bethesda, MD 20892-7940
Phone: (301) 435-0222
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
Office of Extramural
National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
Department of Health
and Human Services (HHS)
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