NOTICE OF LIMITED COMPETITION REQUEST FOR COMPETING APPLICATIONS: NHLBI 
THALASSEMIA CLINICAL RESEARCH NETWORK

RELEASE DATE:  October 3, 2003

NOTICE: NOT-HL-03-017

National Heart, Lung, and Blood Institute (NHLBI)
 (http://www.nhlbi.nih.gov)

APPLICATION RECEIPT DATE:  October 19, 2004

The NHLBI is requesting competing renewal applications from the six grants 
currently funded as part of the Thalassemia Clinical Research Network.  These 
awards resulted from RFA HL-99-016, Thalassemia Clinical Research Network 
(http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-99-016.html).  This 
network provides a unique collaborative structure for clinical studies. The 
extensive time and processes involved in establishing the collaboration 
essential for efficient development and implementation of protocols as a 
network warrants this limited re-competition for one renewal cycle. The 
experience gained by the current group of investigators in working together, 
designing protocols suitable for a clinical research network setting, and 
maintaining high quality follow-up data is considerable. Keeping the group in 
tact for one more grant award cycle will take maximum advantage of this 
experience. Should the grants be successfully reviewed, the current network 
will continue for five more years, depending on the availability of funds. 
After that point, the NHLBI will determine the feasibility of maintaining a 
clinical research network in thalassemia and, if appropriate, the NHLBI will 
issue an entirely new request for applications as an unlimited competition. 

MECHANISM OF SUPPORT

The network uses the cooperative agreement (U01) administrative and funding 
mechanism of support.  Under the cooperative agreement, the NIH assists, 
supports, and/or stimulates, and is substantially involved with recipients in 
conducting a study by facilitating performance of the effort in a "partner" 
role.  Details of the responsibilities, relationships, and governance of a 
study funded under this cooperative agreement will be the same as in the 
current terms and conditions of the award.  Organization, Operation, and 
Oversight remain unchanged from the original RFA. 

SUBMITTING AN APPLICATION

Applications must be prepared using the PHS 398 research grant application 
instructions and forms (rev. 5/2001). Applications must have a Dun and 
Bradstreet (D&B) Data Universal Numbering System (DUNS) number as the 
Universal Identifier when applying for Federal grants or cooperative 
agreements. The DUNS number can be obtained by calling (866) 705-5711 or 
through the web site at http://www.dunandbradstreet.com/. The DUNS number 
should be entered on line 11 of the face page of the PHS 398 form. The PHS 398 
is available at http://grants.nih.gov/grants/funding/phs398/phs398.html in an 
interactive format.  For further assistance contact GrantsInfo, Telephone 
(301) 435-0714, Email: GrantsInfo@nih.gov.

Only competing renewal applications which were funded as part of 
RFA-HL-99-016, Thalassemia Clinical Research Network, will be considered. 

Item 2 on the Face Page should be checked "Yes"; after "Number:" enter 
"NOT-HL-03-017" and after "Title:" enter "Competing Applications for 
Thalassemia Network".

For the Checklist at the end of the application, mark the box "Competing 
Continuation", and fill in the grant application number.

Submit a signed, typewritten original of the application, including the 
Checklist, and three signed, photocopies, in one package to:
 
Center For Scientific Review
National Institutes Of Health
6701 Rockledge Drive, Room 1040, MSC 7710
Bethesda, MD  20892-7710
Bethesda, MD  20817 (for express/courier service)
 
At the time of submission, two additional copies of the application plus all 
five collated sets of appendix material must be sent to:

Anne P. Clark, Ph.D.
Chief, Review Branch
National Heart, Lung, and Blood Institute
National Institutes of Health
6701 Rockledge Drive, Room 7214
Bethesda, MD 20892-7924
Bethesda, MD 20817 (for express/ courier service)
Telephone:  301-435-0270
FAX:  301-480-0730
email:  clarka@nhlbi.nih.gov

Applications must be received on or before the application receipt date listed 
in the heading of this Notice.


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