SYNTHESIS AND TESTING OF NONSTEROIDAL AND NONHORMONAL MALE CONTRACEPTIVE AGENTS

Release Date:  February 23, 2000

NOTICE:  HD-00-003

RFP AVAILABLE:  RFP-NICHD-CRHB-2000-3

National Institute of Child Health and Human Development

The Contraception and Reproductive Health Branch, Center for Population 
Research, National Institute of Child Health and Human Development (NICHD), 
requires the synthesis and testing of non-steroidal and non-hormonal male 
contraceptive agents.  The specific objectives of the project are the design, 
synthesis, and testing of non-steroidal and non-hormonal male contraceptive 
agents that inhibit testicular sperm development, post-testicular sperm 
maturation, and epididymal function.  Such compounds should be devoid of (or 
have minimal) ancillary, central nervous system, cardiovascular, and other 
side effects.  Organizations must have adequate facilities and capabilities 
to carry out the proposed synthetic chemical program.  The Federal Government 
is prepared to test such compounds in several standard assays if the 
contractor is unable to perform such testing.  Specifically excluded from 
this project are GnRH analogs; gossypol derivatives; steroidal agents; all 
alkylating agents including chlorohydrin, deoxychlorosugars, nitrogen 
mustards, ethyleneimines, and sulfonoxyalkanes; nonspecific antimetabolites; 
antimitotic agents; N-substituted diamines (such as Win. 13,099); 
nitroheterocyclic compounds, and cytotoxic agents.  Proposals merely to 
collect compounds from various sources and/or to perform biological assays 
will not be considered.  All responsible sources may submit proposals for 
consideration by the agency.  It is anticipated that three cost-
reimbursement, incrementally funded contracts will be awarded as a result of 
the RFP for a period of 36 months each, beginning September 29, 2000.  

This is not a Request for Pproposals (RFP).  RFP-NICHD-CRHB-2000-03 will be 
issued on or about February 24, 2000.  Proposals will be due approximately 90 
days thereafter.  Copies of the RFP may be obtained by sending a written 
request to the address listed under INQUIRIES below.  Requests may also be 
made by FAX or E-mail.

INQUIRIES

Inquiries regarding this notice should reference RFP-NICHD-CRHB-2000-03, and 
should be directed to:

Paul J. Duska
Contracting Officer
Contracts Management Branch
National Institute of Child Health and Human Development
6100 Executive Blvd., Suite 7A07, MSC 7510
Bethesda, MD  20892-7510
Telephone:  (301) 496-4611
Fax:  (301) 402-3676
E-mail:  pd28n@nih.gov

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