ADMINISTRATIVE SUPPLEMENTS TO SUPPORT DNA MICROARRAY FACILITIES

Release Date:  November 30, 1999

NOTICE:  EY-00-001

National Eye Institute

The National Eye Institute announces the availability of administrative supplements 
to NEI-funded research projects (R01) and Merit Awards (R37) to assist institutions 
with establishing DNA microarray facilities.  The facility must be designed to 
support the application of state-of-the art microarray technologies to innovative 
vision research, to serve a minimum of five NEI-funded research projects, and to 
support research that must be within the scope of the research originally 
recommended by peer-review for the grant to be supplemented.

This administrative supplement program is issued in response to recommendations 
developed at the recent NEI Functional Genomics Workshop.  The goal of the workshop 
was to provide NEI with a set of recommendations for the development of genomic 
resources needed to facilitate understanding of the normal visual system and its 
related disorders and diseases.  More information concerning the workshop can be 
found at http://www.nei.nih.gov.  In addition, information regarding NEI 
programmatic interest in functional genomics is available in NEI's publication 
Vision Research, A National Plan: 1999-2003, which is located at 
http://www.nei.nih.gov/resources/strategicplans/plan.htm.

Requests must be limited to the purchase of equipment, supplies, and technical 
personnel critical to the DNA microarray facility.  Appropriate equipment for which 
support may be requested includes, but is not limited to, DNA arrayers and readers; 
robotic equipment for automation; and, with strong justification, computers for 
informatics.  Since these administrative supplements are intended to assist 
institutions, it is expected that the applicant institutions will support 
personnel, equipment, and supplies associated with the establishment and operation 
of the facility.

Requests must meet the criteria required for all administrative supplements: (1) 
the project period of the grant to be supplemented must have at least two years 
remaining at the time of award and (2) the work proposed must be within the scope 
of the research originally recommended.  Applicants may request up to two years of 
support; the requested budget may not exceed $250,000 total costs in year 1 and 
$100,000 total costs in year 2.  Because funds are limited, NEI will give highest 
priority to administrative supplement requests that meet the following criteria:

1. The applicant has provided a description of five NEI-funded R01 and/or R37 
research projects that will benefit from the presence of a microarray facility, 
including how the array technology will enhance ongoing research projects within 
the scope of the originally proposed specific aims.

2. The applicant has provided documentation of strong institutional commitment to 
support the microarray facility, including continued support for the facility 
and the technology after the time period of the supplement.  Applicants must 
document the resources and environment available at the institution to 
effectively operate the facility, including support for personnel, equipment, 
supplies, and availability of laboratory space.

3. The applicant has provided a detailed budget and budget justification for the 
personnel, equipment or supplies requested.

4. The applicant has provided a detailed description of the administration and 
management of the DNA microarray facility.  Important consideration should be 
given to setting priorities for the facility and ensuring access by the vision 
researchers.

A request for an administrative supplement under this program should include a 
cover letter requesting the administrative supplement and identifying this program.  
The application should be developed using the PHS Form 398 (revised 4/98) Face 
Page, budget Form Pages 4 and 5, Biosketch of the Principal Investigator, and 
resources Form Page 8.  The Research Plan should address points 1 through 4 above 
and should not exceed five pages.

This is a one-time announcement with requests submitted on or before March 8, 2000.  
Requests should be sent to:

Maria Y. Giovanni, Ph.D.
Fundamental Retinal Processes
National Eye Institute
Executive Plaza South, Suite 350
6120 Executive Blvd, MSC 7164
Bethesda, MD 20892-7164
Rockville, MD 20852 (for express/courier service)

The request for the administrative supplement will be evaluated by NEI extramural 
staff.  Awards will be determined on the basis of scientific merit, program 
relevance, and the availability of funds.  The expected award date is May 1, 2000.

INQUIRIES

Inquiries concerning this notice are strongly encouraged.  The opportunity to 
clarify any issue or questions from potential applicant is welcome.

Direct inquiries regarding programmatic issues to:

Maria Y. Giovanni, Ph.D.
Fundamental Retinal Processes
National Eye Institute
Executive Plaza South, Suite 350
6120 Executive Blvd, MSC 7164
Bethesda, MD 20892-7164
Telephone: (301) 496-0484
FAX: (301) 402-0528
Email: myg@nei.nih.gov

Direct fiscal inquiries to:

William W. Darby
Grants Management Branch, NEI
National Eye Institute
Executive Plaza South, Suite 350
6120 Executive Blvd, MSC 7164
Bethesda, MD 20892-7164
Telephone: (301) 496-5884
FAX: (301) 496-9997 
Email: wwd@nei.nih.gov

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	Office of Extramural Research (OER)			National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892			Department of Health and Human Services (HHS)
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