NOT-DC-01-005: ADMINISTRATIVE SUPPLEMENTS TO CREATE TARGETED MOUSE MUTANTS

Department of Health
and Human Services (HHS)

NIH... Turning Discovery Into Health^®

Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.

ADMINISTRATIVE SUPPLEMENTS TO CREATE TARGETED MOUSE MUTANTS Release Date: March 12, 2001 NOTICE: NOT-DC-01-005 National Institute on Deafness and Other Communication Disorders National Institute of Mental Health National Institute of Environmental Health Sciences Receipt Date: June 1, 2001 PURPOSE The National Institute on Deafness and Other Communication Disorders (NIDCD), the National Institute of Mental Health (NIMH), and the National Institute of Environmental Health Sciences (NIEHS) announce a program for administrative supplements to create mice carrying targeted mutations to facilitate the aims of currently-funded research project grants. The program is intended to support ongoing, peer-reviewed projects for which targeted mouse mutants will provide additional data clearly within the scope of the approved project’s Specific Aims. Evidence should be presented that the results of the supplemental assistance will significantly enhance the pursuit of Specific Aims of the parent grant, without constituting an expansion of scope. Descriptions should be concise, but sufficiently detailed to make clear the research plan and the relationship of the design and study of the mutant mice to the goals of the parent grant. The principal focus of this announcement is on the creation of targeted mutations including knockouts, knock-ins, conditional mutants, and other specific mutations. Random mutagenesis is not within the scope of this supplemental program. Principal Investigators holding the following grant mechanisms are eligible to apply: NIDCD, R01, R29, P01, P50, K08, K23, NIMH, R01, NIEHS, R01, P01. Only parent grants with at least 15 months of support remaining from the date of this announcement are eligible for this administrative program. Supplements made under this notice are one-time awards and will not extend to subsequent years. Applications will be reviewed administratively and it is expected that notice of award will be given within approximately three months of the receipt date. Approximately 1.2 million dollars will be available for this supplemental program. Only one supplement request per parent grant may be submitted in response to this solicitation. Participating Institutes will consider supplement requests from all eligible applicants. However, because funds are limited, highest priority will be given to supplement requests that meet the following criteria: o The proposed experiments are within the scope of the parent grant and will significantly improve its progress. o Resources and expertise necessary to perform the experiments are available. o The mutant mouse created will be of significant value to the wider research community as a whole. o Plans to release data and research resources in a timely manner are suitable (see REQUIREMENTS FOR SHARING RESEARCH RESOURCES below). o Clear documentation and justification of the requested budget. o The supplement meets the Institute-specific criteria listed below under ADDITIONAL INSTITUTE-SPECIFIC REQUIREMENTS. REQUIREMENTS FOR SHARING RESEARCH RESOURCES The sharing of biomaterials, data, and software in a timely manner, is an essential element in the rapid progress that has been made in the genetic analysis of mammalian genomes. NIH policy requires that investigators make unique research resources readily available for research purposes to qualified individuals within the scientific community when they have been published [NIH Grants Policy Statement (http://grants.nih.gov/grants/policy/nihgps, Sharing Biomedical Research Resources: Principles and Guidelines for Recipients of NIH Research Grants and Contracts: Final Notice, December 1999 (http://www.nih.gov/od/ott/RTguide_final.htm)]. It is expected that biomaterials and other patentable research resources (e.g. vectors, embryonic cell lines, mutant mice, etc.) produced in projects funded by these administrative supplements will be made available and distributed to the broader scientific community. APPLICATION PROCEDURES The request for the supplemental award MUST include the following: 1. A completed face page, including appropriate signatures, from Grant Application Form PHS 398 (Revised 4/98). Include the title and grant number of the parent grant on line 1 and enter Administrative Supplement for Targeted Mouse Mutants on line 2. 2. An itemized proposed budget entered on the budget pages from Grant Application Form PHS 398. Supplements are for one year and may not exceed $50,000 TOTAL COSTS. The supplement budget must be concurrent with the parent grant funding cycle. Therefore, if the 12-month period of the supplement does not coincide with the parent grant funding cycle, it may be necessary to prorate the supplement budget to coincide with the parent grant’s yearly budget period. 3. The abstract and current aims of the parent grant (maximum 2 pages). 4. A detailed description (maximum 5 pages) of the plans for creation and utilization of the proposed mutant mouse including: a) how the animal will be used to enhance the pursuit of the specific aims of the parent grant, b) technical resources available to develop such a mouse, c) the significance of the work proposed in the supplement, d) a description of the utility of the mutant mouse to the wider research community, and e) plans for providing research resources (e.g. vectors, embryonic cell lines, mutant mice, etc.) to the broader scientific community. 5. Should the proposed research require animal involvement different from that of the parent grant, approving documentation by Institutional Animal Care and Use Committee (IACUC) must be provided. 6. Letters indicating approval and commitment of resources from collaborating institutions/companies. 7. The original and two copies of the entire application package should be sent directly to the appropriate Institute at the address listed below under INSTITUTE CONTACTS. 8. Applications must be received by June 1, 2001. ADDITIONAL INSTITUTE-SPECIFIC REQUIREMENTS Several NIH Institutes are participating in this supplemental program because of a trans-NIH interest in targeted mutant mice as a powerful research tool. In addition, these Institutes recognize the necessity of providing a mechanism to fund the creation of targeted mutants to be used in the hypothesis-driven projects of ongoing research programs. However, the scope and emphasis of supplements requested by each Institute may differ because of Institute-specific factors such as relative focus on basic versus clinical research, current program priorities, and available funds. Therefore, in addition to the above requirements and criteria, applicants MUST carefully review and meet the following INSTITUTE-SPECIFIC CRITERIA AND/OR REQUIREMENTS listed below by the funding Institute of the parent grant. National Institute on Deafness and Other Communication Disorders (NIDCD) The NIDCD will accept supplement applications to develop mice carrying mutations in genes known to cause hereditary hearing or chemosensory impairment in humans. One of the primary goals of this supplement program is to allow laboratories investigating genes that cause hearing or chemosensory impairment in humans to create and study mouse models of the human genetic disorder. Therefore, investigators working in human populations and investigators already working with mouse mutants are both eligible for these supplements. NIDCD anticipates awarding up to 10 supplement requests. Only one supplement request per parent grant (R01, R29, P01, P50, K08, and K23) may be submitted in response to this solicitation. National Institute of Mental Health (NIMH) NIMH will accept supplement applications to develop mice with genetic mutations that result in deficits in complex social behavior, affective regulation and emotionality, sensory functions (e.g., auditory gating) that may be implicated in mental disorders, and cognitive processes (e.g., learning, memory, and attention). Supplement applications that target genes involved in neural circuits or pathways that may be implicated in mental disorders are of particular interest. Funding priority will be given to applications that focus on genes for which targeted mutations have not previously been produced and made publicly available. NIMH anticipates awarding up to eight supplement requests. Only one supplement request per parent grant (R01) may be submitted in response to this solicitation. National Institute of Environmental Health Sciences (NIEHS) NIEHS will accept supplemental applications to develop mice with genetic mutations in the following categories of genes: DNA Repair, cell cycle control, drug metabolizing enzymes, apoptosis and cell differentiation, and signal transduction pathways. Funding priority will be given to applicants that focus on genes for which targeted mutants have not previously been produced and made publicly available. Additional consideration will be given to the development of mouse models that will mimic human genetic variants in the above categories of genes. NIEHS anticipates awarding up to six supplemental requests. Only one supplement request per parent grant (R01 and P01 only) may be submitted in response to this solicitation. INSTITUTE CONTACTS The following individuals will serve as the point of contact for their Institutes. Applicants are encouraged to contact the appropriate Institute program officer with any questions regarding their plans to submit a proposal. Thomas M. Johnson, Ph.D. Program Officer Scientific Programs Branch Hereditary Hearing Impairment National Institute on Deafness and Other Communication Disorders Executive Plaza South-400C 6120 Executive Blvd. Bethesda, MD 20892-7180 Rockville, MD 20852 (for courier/overnight mail service) Tel: 301-402-3461 Fax: 301-402-6251 E-mail: tj65y@nih.gov Barry J. Davis, Ph.D. Program Director Scientific Programs Branch Taste and Smell Programs National Institute on Deafness and Other Communication Disorders Executive Plaza South-400C 6120 Executive Blvd. Bethesda, MD 20892-7180 Rockville, MD 20852 (for courier/overnight mail service) Tel: 301-402-3464 Fax: 301-402-6251 E-mail: barry_davis@nih.gov Hemin Chin, Ph.D. Chief, Genetic Basis of Neural Function Program National Institute of Mental Health 6001 Executive Blvd., Room 7190, MSC 9643 Bethesda, MD 20892-9643 Rockville, MD 20852 (for courier/overnight mail service) Tel: 301-443-1706 Fax: 301-443-9890 E-mail: hchin@mail.nih.gov Jose Velazquez, Ph.D. Scientific Program Administrator Division of Extramural Research and Training National Institute of Environmental Health Sciences P. O. Box 12233, 111 Alexander Drive, MD EC-21 Research Triangle Park, North Carolina 27709 Tel: 919-541-4998 Fax: 919-316-4606 Email: Velazqu1@niehs.nih.gov

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices