Notice Number: NOT-CA-15-012

Key Dates
Release Date: February 13, 2015

Issued by
National Cancer Institute (NCI)

Purpose

The NCI participates in the NIH Parent Program Announcement PA-14-149 "Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32)."  Through this Notice, the NCI announces that eligible applicants are welcome to submit F32 applications to PA-14-149 that request postdoctoral support for studies that are related to a goal of building effective therapeutic approaches for KRAS-driven tumors. KRAS, in particular, is being targeted for study by the NCI (www.cancer.gov/ras) because it is one of the most mutated genes across all cancer types, especially in pancreatic, lung, and colon cancers.

Examples of KRAS-relevant areas of research that are of interest to NCI are listed below. This list is not meant to be exhaustive.

• Protein structures of various alleles of KRAS bound to its effectors.
• Structure-based drug design or identification of protein-protein interaction inhibitors.
• Experimental and/or computational approaches to measure KRAS-dependent signaling pathways in normal and mutant states in various tissues.
• Next generation synthetic lethal screens.
• Identifying ways to attack KRAS cancers using immune-based (cellular or humoral), nanoparticle-based, and/or other therapies.

No aspect of the parent F32 announcement PA-14-149 is changed by this Notice. Moreover, this Notice should NOT be construed as any limitation in the scope of research that may be proposed in F32 applications for NCI support. The NCI encourages all interested and eligible applicants, no matter which area of cancer research they wish to study, to apply to PA-14-149.

NCI-Specific Information pertaining to F32 applications can be found by following the hyperlinked Table of IC-Specific Information, Requirements and Staff Contacts in PA-14-149 (https://grants.nih.gov/grants/guide/contacts/parent_F32.html) and on the NCI web page for the Ruth L. Kirschstein National Research Service Award (NRSA) for Individual Postdoctoral Fellows (F32)
(http://www.cancer.gov/researchandfunding/cancertraining/funding/f32).

Inquiries

Please direct all inquiries to:

Sonia B. Jakowlew, Ph.D.
National Cancer Institute (NCI)
Telephone: 240-276-5630
Email: jakowles@mail.nih.gov

Sara S. Hook, Ph.D.
National Cancer Institute (NCI)
Telephone: 301-451-2412
Email: hookss@mail.nih.gov