Rapid Access to Intervention Development (RAID)

Notice Number: NOT-CA-08-004

Key Dates
Release Date: December 12, 2007

Issued by
National Cancer Institute (NCI) (http://www.nci.nih.gov)

The National Cancer Institute (NCI) is requesting project proposals for access to NCI-sponsored resources provided by the Rapid Access to Intervention Development (RAID) Program (http://dtp.nci.nih.gov/). The RAID Program makes available to academic investigators the preclinical development resources managed by the NCI's Developmental Therapeutics Program (DTP). Access to these resources is granted on a competitive basis following the evaluation of submitted project proposals by an external review committee. However, RAID is not a grant program.

Approved projects will gain access to the drug development contract resources that are managed by DTP staff members. The goal of the RAID Program is the rapid transition of novel molecules and concepts from the laboratory level to the clinic for proof-of-principle clinical trials. The scientific priority of the RAID Program is on areas with disproportionate unmet needs such as:

  • Rare cancers;
  • Pediatric cancers;
  • Clinical/molecular pharmacodynamics;
  • Certain classes of therapeutic biological agents;
  • Natural product drug candidates; and
  • Development of a therapeutic agent and concomitant imaging studies.

The RAID Program will assist investigators who submit successful project proposals by providing any (or all) of the preclinical development steps that may be obstacles to clinical translation. Possible tasks may include: drug candidate production; bulk supply; good manufacturing process (GMP) certification; formulation; and toxicology. Suitable agents for RAID include small molecules and biological therapeutic agents (including vaccines).

There are two windows of opportunity per year to file requests for RAID support. The first window of opportunity will open on January 1 and end on February 1, 2009, at 5:00 p.m. EST. All RAID proposals must be filed electronically using a dedicated secure web site managed by the NCI DTP (for details and instructions please see http://dtp.nci.nih.gov/docs/raid/raid-es.html). Paper copies of RAID proposals will not be accepted via any means of delivery. Since RAID proposals ARE NOT grant applications, they ARE NOT processed by the Center for Scientific Review (CSR).

For general information on the procedures for requesting RAID resources visit the DTP website at http://dtp.nci.nih.gov/nquiries are encouraged and DTP staff members welcome opportunities to clarify issues or to answer questions about the RAID Program. Academic investigators may have collaborations with small-business partners and still qualify for RAID access. Non-profit organizations other than universities may also submit project proposals to RAID. Please note that a maximum of two distinct requests for support per investigator can be submitted for each receipt date.

Inquiries

Inquiries regarding this Notice may be directed to:

RAID
Office of Associate Director
Developmental Therapeutics Program
Division of Cancer Treatment and Diagnosis
National Cancer Institute
6130 Executive Boulevard, EPN Suite 8022, MSC 7458
Bethesda, MD 20892-7458
Telephone: 301-496-8720
Fax: 301-402-0831
Email: raid@dtpax2.ncifcrf.gov