NIH AUTOIMMUNE RAT MODEL REPOSITORY AND DEVELOPMENT CENTER

Release Date:  March 26, 2001

NOTICE:  NOT-AR-01-005

National Institute of Arthritis and Musculoskeletal and Skin Diseases

The NIH Animal Genetic Resource of the Veterinary Resources Program/ 
Office of Research Services and the National Institute of Arthritis and 
Musculoskeletal and Skin Diseases 

The NIH Autoimmune Rat Model Repository and Development Center 
announces the availability of breeding stock of standard and new rat 
strains for research on autoimmune disorders.  Information concerning 
rat strains currently available and nearing release is available from 
the resource managers listed below and will be listed on the resource 
web site at:  http://www.ors.od.nih.gov/dirs/vrp/ratcenter/.  

The NIH Autoimmune Rat Model Repository and Development Center was 
established in 2000 and is funded by the National Institute of 
Arthritis and Musculoskeletal and Skin Diseases (NIAMS).  The purpose 
of the Repository is to facilitate the availability of genetically-
standardized rat strains for experimental research of the role of 
autoimmunity in diabetes, rheumatoid arthritis, multiple sclerosis, 
systemic lupus erythematosus, encephalomyelitis, spondyloarthropathy, 
and other diseases.  The NIH Animal Genetic Resource of the Veterinary 
Resources Program, Office of Research Services, NIH operates the 
Autoimmune Rat Model Repository and Development Center.

Resource Objectives 
1. To acquire, characterize, establish, develop, and cryopreserve 
foundation colonies of genetically-characterized autoimmune rat models. 
All strains will be re-derived on arrival to eliminate disease 
pathogens and parasites that may complicate research. Breeding stock 
will be available to qualified biomedical investigators worldwide. 

2. To assist autoimmune research investigators in the development of 
novel and enhanced models using special breeding schemes to obtain 
inbred (e.g., standard inbred strains, congenic, recombinant inbred, 
consomic, recombinant congenic) and outbred models. Projects will be 
selected using criteria established with the assistance of an Advisory 
Group consisting of NIH intramural, extramural and international 
investigators.

Inquiries regarding the availability of rat models of autoimmune 
disorders should be addressed to:

Drs. Carl T. Hansen and Dr. William F. Rall, Resource Managers
Veterinary Resources Program/Office of Research Services/NIH
14 Service Road South, Building 14F, Room 101
Bethesda, MD 20892-5590
Telephone:  (301) 496-5525
Fax:  (301) 402-4258
E-mail: ch45j@nih.gov or br18a@nih.gov

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