RFP ANNOUNCEMENT:  DEVELOPMENT OF IMMUNE MONITORING REAGENTS AND MHC TYPING 
TECHNOLOGIES FOR NON-HUMAN PRIMATES - NIH-NIAID-DAIT-04-24

RELEASE DATE:  December 2, 2003

NOTICE:  NOT-AI-04-007

National Institute of Allergy and Infectious Diseases (NIAID) 
 (http://www.niaid.nih.gov)

RECEIPT DATE:  March 1, 2004

DESCRIPTION 

This Request for Proposals (RFP) reflects the continuing commitment of the 
Division of Allergy, Immunology, and Transplantation (DAIT) of the National 
Institute of Allergy and Infectious Diseases (NIAID) to advancing pre-
clinical, non-human primate (NHP) research in the fields of infectious 
disease vaccine development, transplantation, and autoimmune diseases. 
Cynomolgus macaque (Macaca fasicularis), Rhesus macaque (Macaca mulatta), 
Pigtail macaque (Macaca nemestrina), and baboon (Papio hamadrya) are the NHP 
species that are the primary focus of this RFP, unless otherwise directed by 
the Government. The RFP details two (2) Parts, each with its own Statement of 
Work.  PART I: Reagent Development for Monitoring Immunity in Non-Human 
Primates - solicits proposals to develop, evaluate, produce and distribute 
new or improved NHP immune monitoring and immune modulating reagents that are 
needed to: (1) evaluate NHP immune responses in vaccine and adjuvant 
development for infectious diseases, transplantation research, and autoimmune 
and infectious diseases models; and (2) develop novel immune-based 
therapeutics, vaccines and adjuvants. The Government will designate the 
reagents for development and limited-scale production and distribution based 
on recommendations by a Scientific Advisory Committee (SAC) appointed by 
NIAID. The prime Contractor for Part I shall be a domestic organization or 
institution.  PART II:  Major Histocompatibility Complex (MHC) Typing 
Technologies for Non-Human Primates - solicits proposals to develop rapid, 
high-throughput, medium- to high-resolution technologies for major 
histocompatibility complex (MHC) typing of NHP species. A high degree of MHC 
gene/allele discovery is required for development and validation of the 
typing technologies. The prime Contractor(s) for Part II may be a domestic or 
foreign organization(s)/institution(s).

Offerors may submit a proposal for either Part I or Part II.  Offerors 
submitting proposals for both Part I and Part II under this solicitation must 
prepare separate proposals for each part.  Proposals for Part I and Part II 
will be evaluated individually and, possibly, by separate review groups. If 
an offeror is funded for both Part I and Part II, the two (2) parts will be 
combined during the contract negotiation phase.  The central goal of this RFP 
is to provide the development of products and technologies, with 
commercialization rights, that will remain freely accessible to the NHP 
research community. It is anticipated that one (1), five (5) year contract 
will be awarded for Part I; and one (1) to two (2) contracts will be awarded 
for Part II, for up to five (5) years duration beginning on or about 
September 30, 2004.  RFP NIH-NIAID-DAIT-04-24 will be available 
electronically on or about November 20, 2003, and may be accessed through the 
NIAID Contract Management Branch (CMB) Home Page at 
http://www.niaid.nih.gov/contract and will be posted on FedBizOpps at 
http://www.fedbizopps.gov/. Responses to this RFP will be due on March 18, 
2004.  Any responsible Offeror may submit a proposal that will be considered 
by the Government.  This advertisement does not commit the Government to 
award a contract.  No collect calls will be accepted.  

Contracting Office Address:

Department of Health and Human Services
National Institutes of Health
National Institutes of Allergy and Infectious Diseases
Division of Extramural Activities
Contract Management Branch 
6700-B Rockledge Drive
Room 2230, MSC 7612 
Bethesda, MD, 20892-7612

Point of Contact:

Carl Newman, Contract Specialist, Phone 301-496-8371, Fax 301-402-0972, 
Email cn109s@nih.gov
Paul McFarlane, Contracting Officer, Phone 301-496-0349, Fax 301-480-5253, 
Email pm24@nih.gov

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