POLICY ON SUPPORT OF LARGE-SCALE GENOME SEQUENCING PROJECTS ADDENDUM FOR POTENTIAL BIOTERRORISM AGENTS Release Date: March 7, 2000 NOTICE: AI-00-004 National Institute of Allergy and Infectious Diseases Defense Advanced Research Projects Agency On September 27, 1999, the National Institute of Allergy and Infectious Diseases (NIAID) announced a new policy on support of genome sequencing projects, see http://grants.nih.gov/grants/guide/notice-files/not99-148.html. Detailed information on the NIAID genome sequencing program can be found at http://www.niaid.nih.gov/dmid/genomes/. This addendum announces an opportunity for support of large-scale projects for sequencing of high priority pathogens as potential agents for bioterrorism. Except for the addition of these priority pathogens and an added receipt date for applications, all provisions of policy notice of September 27, 1999 are still applicable. The National Institute of Allergy and Infectious Diseases (NIAID) with funds provided by the Defense Advanced Research Projects Agency (DARPA) will accept and consider for funding, under the conditions presented below, research applications for large-scale genome sequencing of microbial pathogens that have the potential to be used as agents of bioterrorism. 1. PRIORITY BIOTERRORISM AGENTS. The priority organisms covered by this addendum are listed at: http://www.niaid.nih.gov/dmid/genomes/priorities.htm. 2. ADDED APPLICATION RECEIPT DATE. Applications for sequencing of priority bioterrorism pathogens must be submitted for the receipt on April 18, 2000 to enable funding by September 2000. INQUIRIES Inquiries concerning this policy are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries to: Dr. Michael Gottlieb Division of Microbiology and Infectious Diseases National Institute of Allergy and Infectious Diseases Room 3102 6700-B Rockledge Drive MSC 7630 Bethesda, MD 20892-7630 Telephone: 301.496.2544 FAX: 301.402.0659 E-mail: mg35s@nih.gov Dr. Eric Eisenstadt DARPA/DSO 3701 Fairfax Drive Arlington, VA 22203-1714 Telephone: 703.696.2322 Fax: 703.696.3999 E-mail: eeisenstadt@darpa.mil

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